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Summary[edit | edit source]

  • pan ID?: SAUPAN005555000
  • symbol?: sepA
  • synonym:
  • description?: multidrug resistance efflux pump SepA

      descriptions from strain specific annotations:

    • multidrug resistance efflux pump SepA
    • multidrug efflux transporter SepA
    • SmrB
  • strand?: -
  • coordinates?: 5699286..5699753
  • synteny block?: BlockID0043160
  • occurrence?: in 100% of 33 strains

sepA: staphylococcal multidrug efflux pump A [1]

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_2106 (smrB)
    08BA02176:
    C248_2204
    11819-97:
    MS7_2191 (sepA)
    6850:
    RSAU_002012
    71193:
    ST398NM01_2228
    ECT-R 2:
    ECTR2_2029
    ED133:
    SAOV_2215c
    ED98:
    SAAV_2229
    HO 5096 0412:
    SAEMRSA15_20730
    JH1:
    SaurJH1_2237
    JH9:
    SaurJH9_2199
    JKD6008:
    SAA6008_02206
    JKD6159:
    SAA6159_02079
    LGA251:
    SARLGA251_19630
    M013:
    M013TW_2134
    MRSA252:
    SAR2259
    MSHR1132:
    SAMSHR1132_20000
    MSSA476:
    SAS2069
    Mu3:
    SAHV_2151 (sepA)
    Mu50:
    SAV2167
    MW2:
    MW2094
    RF122:
    SAB2049c
    ST398:
    SAPIG2228
    T0131:
    SAT0131_02336
    TCH60:
    HMPREF0772_11024
    TW20:
    SATW20_23030
    USA300_TCH1516:
    USA300HOU_2159
    VC40:
    SAVC_09710

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MIVNYLKHKFYNLLTTMIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMY
    N315            MIVNYLKHKFYNLLTTMIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMY
    NCTC8325        MIVNYLKHKFYNLLTTMIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMY
    Newman          MIVNYLKHKFYNLLTTMIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMY
    USA300_FPR3757  MIVNYLKHKFYNLLTTMIVLFIFVLSGAIFLTFLGFGLYGLSRILIYFRLGDFTYNRSMY
                    ************************************************************

    COL             DNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHL
    N315            DNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHL
    NCTC8325        DNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHL
    Newman          DNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHL
    USA300_FPR3757  DNLLYYGSYIIFGYFIIFAVEHLMDYFRKMLPENAYFRGATFHLISYTVATTLFYFIIHL
                    ************************************************************

    COL             NYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
    N315            NYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
    NCTC8325        NYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
    Newman          NYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
    USA300_FPR3757  NYVYINIDFWVIMVIIGFLYVCKLQFYPESKNLNNRK
                    *************************************

  1. Koji Narui, Norihisa Noguchi, Kazunori Wakasugi, Masanori Sasatsu
    Cloning and characterization of a novel chromosomal drug efflux gene in Staphylococcus aureus.
    Biol Pharm Bull: 2002, 25(12);1533-6
    [PubMed:12499635] [WorldCat.org] [DOI] (P p)