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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005823000
- symbol?: lyrA
- synonym:
- description?: lysostaphin resistance protein A
- lysostaphin resistance protein A
- CPBP family intramembrane glutamic endopeptidase SdpC
- CPBP family intramembrane metalloprotease SdpC
- abortive infection protein
- CAAX amino terminal protease family protein
- Lysostaphin resistance protein A, lyrA
- membrane protein
- metal-dependent membrane protease
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 5909928..5911199
- synteny block?: BlockID0045680
- occurrence?: in 100% of 34 strains
lyrA (spdC) : histidine kinase signal transduction-modulating membrane protein [1]
• A crystal structure is available : 6U0O
• This integral membrane protein is a bona fide virulence factor in that it modulates so many signal transduction cascades. It binds to 13 of the 18 staphylococcal histidine kinases where it can increase (SaeS) or decrease (WalK) phosphorylation of the cognate response regulator. It also appears to associate with some transglycosylases where it serves as a surrogate membrane anchor. Its primary regulatory effects are seen in responses to cell envelope stresses, but whether that is from increased peptidoglycan crosslinking via direct SagB interactions or altered WalK signaling is unclear.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2274
08BA02176:
C248_2377 (lyrA)
11819-97:
MS7_2353 (lyrA)
6850:
RSAU_002170 (lyrA)
71193:
ST398NM01_2387
ECT-R 2:
ECTR2_2195
ED133:
SAOV_2375
ED98:
SAAV_2399
HO 5096 0412:
SAEMRSA15_22320
JH1:
SaurJH1_2403
JH9:
SaurJH9_2360
JKD6008:
SAA6008_02373
JKD6159:
SAA6159_02239
JSNZ:
JSNZ_002302 (sdpC)
LGA251:
SARLGA251_21180
M013:
M013TW_2292
MRSA252:
SAR2421
MSHR1132:
SAMSHR1132_21600
MSSA476:
SAS2227
Mu3:
SAHV_2319
Mu50:
SAV2335
MW2:
MW2255
RF122:
SAB2212
ST398:
SAPIG2387
T0131:
SAT0131_02520 (cysJ)
TCH60:
HMPREF0772_10859
TW20:
SATW20_24670
USA300_TCH1516:
USA300HOU_2315
VC40:
SAVC_10540
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
N315 MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
NCTC8325 MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
Newman MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
USA300_FPR3757 MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
************************************************************
COL FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
N315 FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
NCTC8325 FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
Newman FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
USA300_FPR3757 FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
************************************************************
COL THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
N315 THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
NCTC8325 THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
Newman THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
USA300_FPR3757 THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
************************************************************
COL FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
N315 FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
NCTC8325 FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
Newman FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
USA300_FPR3757 FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
************************************************************
COL VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
N315 VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
NCTC8325 VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
Newman VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
USA300_FPR3757 VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
************************************************************
COL GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
N315 GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
NCTC8325 GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
Newman GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
USA300_FPR3757 GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
************************************************************
COL ESVKQAPQSDDLTNDSNEDEIEQSLKEPVTYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
N315 ESVKQAPQSDDLTNDSNEDEIEQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
NCTC8325 ESVKQAPQSDDLTNDSNEDEIEQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
Newman ESVKQAPQSDDLTNDSNEDEIEQSLKEPVTYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
USA300_FPR3757 ESVKQAPQSDDLTNDSNEDEIEQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
****************************.******************************
- ↑ Matthew B Frankel, Brandon M Wojcik, Andrea C DeDent, Dominique M Missiakas, Olaf Schneewind
ABI domain-containing proteins contribute to surface protein display and cell division in Staphylococcus aureus.
Mol Microbiol: 2010, 78(1);238-52
[PubMed:20923422] [WorldCat.org] [DOI] (I p)Olivier Poupel, Caroline Proux, Bernd Jagla, Tarek Msadek, Sarah Dubrac
SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus.
PLoS Pathog: 2018, 14(3);e1006917
[PubMed:29543889] [WorldCat.org] [DOI] (I e)Stephanie Willing, Olaf Schneewind, Dominique Missiakas
Regulated cleavage of glycan strands by the murein hydrolase SagB in S. aureus involves a direct interaction with LyrA (SpdC).
J Bacteriol: 2021, 203(9);
[PubMed:33593946] [WorldCat.org] [DOI] (I p)