From AureoWiki
Jump to navigation Jump to search

Summary[edit | edit source]

  • pan ID?: SAUPAN005823000
  • symbol?: lyrA
  • synonym:
  • description?: lysostaphin resistance protein A

      descriptions from strain specific annotations:

    • lysostaphin resistance protein A
    • CPBP family intramembrane glutamic endopeptidase SdpC
    • CPBP family intramembrane metalloprotease SdpC
    • abortive infection protein
    • CAAX amino terminal protease family protein
    • Lysostaphin resistance protein A, lyrA
    • membrane protein
    • metal-dependent membrane protease
  • strand?: +
  • coordinates?: 5909928..5911199
  • synteny block?: BlockID0045680
  • occurrence?: in 100% of 34 strains

lyrA (spdC) : histidine kinase signal transduction-modulating membrane protein [1]

• A crystal structure is available : 6U0O

• This integral membrane protein is a bona fide virulence factor in that it modulates so many signal transduction cascades. It binds to 13 of the 18 staphylococcal histidine kinases where it can increase (SaeS) or decrease (WalK) phosphorylation of the cognate response regulator. It also appears to associate with some transglycosylases where it serves as a surrogate membrane anchor. Its primary regulatory effects are seen in responses to cell envelope stresses, but whether that is from increased peptidoglycan crosslinking via direct SagB interactions or altered WalK signaling is unclear.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_2274
    08BA02176:
    C248_2377 (lyrA)
    11819-97:
    MS7_2353 (lyrA)
    6850:
    RSAU_002170 (lyrA)
    71193:
    ST398NM01_2387
    ECT-R 2:
    ECTR2_2195
    ED133:
    SAOV_2375
    ED98:
    SAAV_2399
    HO 5096 0412:
    SAEMRSA15_22320
    JH1:
    SaurJH1_2403
    JH9:
    SaurJH9_2360
    JKD6008:
    SAA6008_02373
    JKD6159:
    SAA6159_02239
    JSNZ:
    JSNZ_002302 (sdpC)
    LGA251:
    SARLGA251_21180
    M013:
    M013TW_2292
    MRSA252:
    SAR2421
    MSHR1132:
    SAMSHR1132_21600
    MSSA476:
    SAS2227
    Mu3:
    SAHV_2319
    Mu50:
    SAV2335
    MW2:
    MW2255
    RF122:
    SAB2212
    ST398:
    SAPIG2387
    T0131:
    SAT0131_02520 (cysJ)
    TCH60:
    HMPREF0772_10859
    TW20:
    SATW20_24670
    USA300_TCH1516:
    USA300HOU_2315
    VC40:
    SAVC_10540

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
    N315            MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
    NCTC8325        MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
    Newman          MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
    USA300_FPR3757  MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILV
                    ************************************************************

    COL             FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
    N315            FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
    NCTC8325        FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
    Newman          FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
    USA300_FPR3757  FKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPI
                    ************************************************************

    COL             THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
    N315            THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
    NCTC8325        THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
    Newman          THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
    USA300_FPR3757  THILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYN
                    ************************************************************

    COL             FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
    N315            FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
    NCTC8325        FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
    Newman          FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
    USA300_FPR3757  FLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAI
                    ************************************************************

    COL             VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
    N315            VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
    NCTC8325        VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
    Newman          VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
    USA300_FPR3757  VAVGYIGLSLIIRGIAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKT
                    ************************************************************

    COL             GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
    N315            GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
    NCTC8325        GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
    Newman          GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
    USA300_FPR3757  GVATASTVGVAKNDTENTVADEPSIHEGTEKTEPQHHIGNQTESNHDEDHDITSESVESA
                    ************************************************************

    COL             ESVKQAPQSDDLTNDSNEDEIEQSLKEPVTYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
    N315            ESVKQAPQSDDLTNDSNEDEIEQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
    NCTC8325        ESVKQAPQSDDLTNDSNEDEIEQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
    Newman          ESVKQAPQSDDLTNDSNEDEIEQSLKEPVTYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
    USA300_FPR3757  ESVKQAPQSDDLTNDSNEDEIEQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
                    ****************************.******************************

  1. Matthew B Frankel, Brandon M Wojcik, Andrea C DeDent, Dominique M Missiakas, Olaf Schneewind
    ABI domain-containing proteins contribute to surface protein display and cell division in Staphylococcus aureus.
    Mol Microbiol: 2010, 78(1);238-52
    [PubMed:20923422] [WorldCat.org] [DOI] (I p)
    Olivier Poupel, Caroline Proux, Bernd Jagla, Tarek Msadek, Sarah Dubrac
    SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus.
    PLoS Pathog: 2018, 14(3);e1006917
    [PubMed:29543889] [WorldCat.org] [DOI] (I e)
    Stephanie Willing, Olaf Schneewind, Dominique Missiakas
    Regulated cleavage of glycan strands by the murein hydrolase SagB in S. aureus involves a direct interaction with LyrA (SpdC).
    J Bacteriol: 2021, 203(9);
    [PubMed:33593946] [WorldCat.org] [DOI] (I p)