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Summary[edit | edit source]

  • pan ID?: SAUPAN005873000
  • symbol?:
  • synonym:
  • description?: DUF3021 domain-containing protein

      descriptions from strain specific annotations:

    • DUF3021 domain-containing protein
    • membrane associated protein
    • membrane protein
    • probable membrane protein
  • strand?: +
  • coordinates?: 5945043..5945498
  • synteny block?: BlockID0046180
  • occurrence?: in 100% of 34 strains

brpS : biofilm-regulating protein sensor [1] [2]

The BrpSR system represents a structurally-distinct, LytTR-type two-component system that likely responds to a competence-stimulating pheromone. Upon pheromone binding, BrpR is released and biofilm production is repressed. BrpR also may be involved in more global regulation including sortase repression, metabolic dormancy, late-stage competence and LrgA-mediated programmed cell death.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    JSNZ:
    04-02981:
    SA2981_2303
    08BA02176:
    C248_2409
    11819-97:
    MS7_2382
    6850:
    RSAU_002199
    71193:
    ST398NM01_2417
    ECT-R 2:
    ECTR2_2224
    ED133:
    SAOV_2408
    ED98:
    SAAV_2429
    HO 5096 0412:
    SAEMRSA15_22620
    JH1:
    SaurJH1_2434
    JH9:
    SaurJH9_2388
    JKD6008:
    SAA6008_02402
    JKD6159:
    SAA6159_02268
    LGA251:
    SARLGA251_21470
    M013:
    M013TW_2322
    MRSA252:
    SAR2450
    MSHR1132:
    SAMSHR1132_21890
    MSSA476:
    SAS2255
    Mu3:
    SAHV_2348
    Mu50:
    SAV2364
    MW2:
    MW2285
    RF122:
    SAB2243
    ST398:
    SAPIG2417
    T0131:
    SAT0131_02552 (tnpA-3)
    TCH60:
    HMPREF0772_10828
    TW20:
    SATW20_24960
    USA300_TCH1516:
    USA300HOU_2347
    VC40:
    SAVC_10690

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757
JSNZ

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.505)


    COL             MKNLKNSLFISLIIGLSLSLFFSMLFADGKYYPLNPQSTIGILYYTHFTETTVMLISIIL
    N315            MKNLKNSLFISLIIGLSLSLFFSMLFADGKYYPLNPQSTIGILYYNHFTETTVMLISIIL
    NCTC8325        MKNLKNSLFISLIIGLSLSLFFSMLFADGKYYPLNPQSTIGILYYTHFTETTVMLISIIL
    Newman          MKNLKNSLFISLIIGLSLSLFFSMLFADGKYYPLNPQSTIGILYYTHFTETTVMLISIIL
    USA300_FPR3757  MKNLKNSLFISLIIGLSLSLFFSMLFADGKYYPLNPQSTIGILYYTHFTETTVMLISIIL
    JSNZ            MKNLKNSLFISLIIGLSLSLFFSMLFADGKYYPLNPQSTIGILYYTHFTETTVMLISIIL
                    *********************************************.**************

    COL             WLLIGVVFFLGDFIFKYTDWSITKATIMHFITTYVGFLPLAMLAGWFPLTVHYLIIFTII
    N315            WLLIGVVFFLGDFIFKYTDWSITKATIMHFITTYVGFLPLAMLAGWFPLTVHYLIIFTII
    NCTC8325        WLLIGVVFFLGDFIFKYTDWSITKATIMHFITTYVGFLPLAMLAGWFPLTVHYLIIFTII
    Newman          WLLIGVVFFLGDFIFKYTDWSITKATIMHFITTYVGFLPLAMLAGWFPLTVHYLIIFTII
    USA300_FPR3757  WLLIGVVFFLGDFIFKYTDWSITKATIMHFITTYVGFLPLAMLAGWFPLTVHYLIIFTII
    JSNZ            WLLIGVVFFLGDFIFKYTDWSITKATIMHFITTYVGFLPLAMLAGWFPLTAHYLIIFTII
                    **************************************************.*********

    COL             FIVVYVLIWIIQFFKNKNYVDTINKQLKQLK
    N315            FIVIYVLIWIIQFFKNKNYVDTINEQLKQLK
    NCTC8325        FIVVYVLIWIIQFFKNKNYVDTINKQLKQLK
    Newman          FIVVYVLIWIIQFFKNKNYVDTINKQLKQLK
    USA300_FPR3757  FIVVYVLIWIIQFFKNKNYVDTINKQLKQLK
    JSNZ            FIVVYVLIWIIQFFKNKNYVDTINKQLKQLK
                    ***:********************:******

  1. Zank A, Schulte L, Brandon X, Carstensen L, Wescott A, Schwan WR. Mutations of the brpR and brpS genes affect biofilm formation in Staphylococcus aureus. World J Clin Infect Dis 2022; 12(1): 20-32 [DOI: 10.5495/wjcid.v12.i1.20]
  2. Shinya Yamauchi, So Shimoda, Akio Kawahara, Tomohiro Sugahara, Shuhei Yamamoto, Masao Kitabayashi, Atsushi Sogabe, Christine A Jansen, Ryuta Tobe, Ryota Hirakawa, Jahidul Islam, Mutsumi Furukawa, Hiroshi Yoneyama, Tomonori Nochi
    Identification of four genes responsible for antimicrobial resistance of MEL-B against S. aureus.
    Biochem Biophys Res Commun: 2024, 699;149566
    [PubMed:38290176] [WorldCat.org] [DOI] (I p)