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⊟Summary[edit | edit source]
- pan ID?: SAUPAN005978000
- symbol?: —
- synonym:
- description?: GtrA family protein
- GtrA family protein
- GtrA-like membrane protein
- Putative sugar translocase in surface polysaccharides biosynthesis
- gtrA-like family protein
- GtrA-like integral membrane protein
- Monosaccharide translocase (flippase type)
- probable membrane protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6040260..6040646
- synteny block?: BlockID0047220
- occurrence?: in 100% of 33 strains
gtcA: N-acetylglucosaminyl-undecaprenol flippase [1]
GtcA is a part of the glycosylation pathway of extracellular lipoteichoic acid modifications
• In the LTA glycosylation pathway, CsbB transfers NAG to an undecaprenol carrier in the cytoplasm which traffics it to the inner leaflet of the cell membrane. GtcA flips it to the outer leaflet where YfhO can transfer NAG to the 2-OH of the extracellular poly-glycerophosphate LTA.
• Under high salt conditions, the alternate sigma factor SigB activates LTA glycosylation and represses LTA D-alanylation.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2368
08BA02176:
C248_2480
11819-97:
MS7_2445
6850:
RSAU_002271
71193:
ST398NM01_2483
ECT-R 2:
ECTR2_2289
ED133:
SAOV_2481c
ED98:
SAAV_2497
HO 5096 0412:
SAEMRSA15_23310
JH1:
SaurJH1_2506
JH9:
SaurJH9_2457
JKD6008:
SAA6008_02472 (gtrA)
JKD6159:
SAA6159_02329 (gtrA)
LGA251:
SARLGA251_22120
M013:
M013TW_2394
MRSA252:
SAR2521
MSHR1132:
SAMSHR1132_22590
MSSA476:
SAS2323
Mu3:
SAHV_2415
Mu50:
SAV2431
MW2:
MW2355
RF122:
SAB2313c
ST398:
SAPIG2483
T0131:
SAT0131_02626 (recG)
TCH60:
HMPREF0772_10757
TW20:
SATW20_25600
USA300_TCH1516:
USA300HOU_2416
VC40:
SAVC_11030
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKLTQTHAEILKFIIVGGINTLNYYVVYLLLLKLLHIEYMISHITGFLVAFVISYYLNCY
N315 MKLTQTHAEILKFIIVGGINTLNYYVVYLLLLKLLHIEYMISHITGFLVAFVISYYLNCY
NCTC8325 MKLTQTHAEILKFIIVGGINTLNYYVVYLLLLKLLHIEYMISHITGFLVAFVISYYLNCY
Newman MKLTQTHAEILKFIIVGGINTLNYYVVYLLLLKLLHIEYMISHITGFLVAFVISYYLNCY
USA300_FPR3757 MKLTQTHAEILKFIIVGGINTLNYYVVYLLLLKLLHIEYMISHITGFLVAFVISYYLNCY
************************************************************
COL FVYRVKPTWRKFISFPITQIVNVSLQTVLLYVFVSWLNLPAEIAPFAGLIITIPITFILS
N315 FVYRVKPTWRKFISFPITQIVNVSLQTVLLYVFVSWLNLPAEIAPFAGLVITIPITFVLS
NCTC8325 FVYRVKPTWRKFISFPITQIVNVSLQTVLLYVFVSWLNLPAEIAPFAGLIITIPITFILS
Newman FVYRVKPTWRKFISFPITQIVNVSLQTVLLYVFVSWLNLPAEIAPFAGLIITIPITFILS
USA300_FPR3757 FVYRVKPTWRKFISFPITQIVNVSLQTVLLYVFVSWLNLPAEIAPFAGLIITIPITFILS
*************************************************:*******:**
COL KWILKDSN
N315 KWILKDSN
NCTC8325 KWILKDSN
Newman KWILKDSN
USA300_FPR3757 KWILKDSN
********
- ↑ Kelvin Kho, Timothy C Meredith
Salt-Induced Stress Stimulates a Lipoteichoic Acid-Specific Three-Component Glycosylation System in Staphylococcus aureus.
J Bacteriol: 2018, 200(12);
[PubMed:29632092] [WorldCat.org] [DOI] (I e)Li Liu, Bingjie Wang, Jingyi Yu, Yinjuan Guo, Fangyou Yu
NWMN2330 May Be Associated with the Virulence of Staphylococcus aureus by Increasing the Expression of hla and saeRS.
Infect Drug Resist: 2022, 15;2853-2864
[PubMed:35677526] [WorldCat.org] [DOI] (P e)