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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006028000
- symbol?: cntM
- synonym:
- description?: staphylopine dehydrogenase CntM
- strand?: -
- coordinates?: 6084949..6086166
- synteny block?: BlockID0047720
- occurrence?: in 100% of 34 strains
cntM : staphylopine biosynthesis bifunctional opine dehydrogenase/pyruvate ligase [1]
• A crystal structure is available: 6H31
Staphylococci synthesize the nicotinamide metallophore staphylopine to scavenge trace metals from the environment. CntM catalyzes the reductive condensation of pyruvate and the nicotinamide intermediate of the CntL reaction to generate staphylopine.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2405
08BA02176:
C248_2518
11819-97:
MS7_2481
6850:
RSAU_002306
71193:
ST398NM01_2518
ECT-R 2:
ECTR2_2325
ED133:
SAOV_2518c
ED98:
SAAV_2534
HO 5096 0412:
SAEMRSA15_23660
JH1:
SaurJH1_2544
JH9:
SaurJH9_2495
JKD6008:
SAA6008_02509
JKD6159:
SAA6159_02365
LGA251:
SARLGA251_22480
M013:
M013TW_2428
MRSA252:
SAR2555
MSHR1132:
SAMSHR1132_22930
MSSA476:
SAS2359
Mu3:
SAHV_2452
Mu50:
SAV2468
MW2:
MW2392
RF122:
SAB2351c
ST398:
SAPIG2518
T0131:
SAT0131_02667 (gid)
TCH60:
HMPREF0772_10721
TW20:
SATW20_25960
USA300_TCH1516:
USA300HOU_2459
VC40:
SAVC_11210
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
COL -----------------------------MVGRASTSEKSKRLYQAYKKEKQFEVKIQNE
N315 MSKLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQAYKKEKQFEVKIQNE
NCTC8325 -----------------------------MVGRASTSEKSKRLYQAYKKEKQFEVKIQNE
Newman MSKLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQAYKKEKQFEVKIQNE
USA300_FPR3757 -----------------------------MVGRASTSEKSKRLYQAYKKAKQFEVKIQNE
JSNZ MSKLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQAYKKEKQFEVKIQNE
******************** **********
COL AHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISP
N315 AHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISP
NCTC8325 AHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISP
Newman AHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISP
USA300_FPR3757 AHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISP
JSNZ AHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISP
************************************************************
COL TFGSQMIVEQFMSKFNKDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNS
N315 TFGSQMIVEQFMSKFSQDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNS
NCTC8325 TFGSQMIVEQFMSKFNKDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNS
Newman TFGSQMIVEQFMSKFNKDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNS
USA300_FPR3757 TFGSQMIVEQFMSKFNKDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNS
JSNZ TFGSQMIVEQFMSKFSQDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNS
***************.:*******************************************
COL TMCQRISALAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVY
N315 TMCQRISALAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVY
NCTC8325 TMCQRISALAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVY
Newman TMCQRISALAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVY
USA300_FPR3757 TMCQRISALAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVY
JSNZ TMCQRISALAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVY
************************************************************
COL KLFPEGPITMTLIREMRLMWKEMMVILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEH
N315 KLFPEGPITMTLIREMRLMWKEMMAILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEH
NCTC8325 KLFPEGPITMTLIREMRLMWKEMMVILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEH
Newman KLFPEGPITMTLIREMRLMWKEMMVILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEH
USA300_FPR3757 KLFPEGPITMTLIREMRLMWKEMMVILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEH
JSNZ KLFPEGPITMTLIREMRLMWKEMMAILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEH
************************.***********************************
COL FEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPS
N315 FEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPS
NCTC8325 FEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPS
Newman FEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPS
USA300_FPR3757 FEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPS
JSNZ FEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPS
************************************************************
COL EDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQHLSSQFNTNLFEGDKA
N315 EDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQQLSSQFNTNLFEGDKA
NCTC8325 EDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQHLSSQFNTNLFEGDKA
Newman EDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQHLSSQFNTNLFEGDKA
USA300_FPR3757 EDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQHLSSQFNTNLFEGDKA
JSNZ EDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQQLSSQFNTNLFEGDKA
********************************************:***************
COL LVTKFLEINRTLS-
N315 LVTKFLEINRTLS-
NCTC8325 LVTKFLEINRTLS-
Newman LVTKFLEINRTLS-
USA300_FPR3757 LVTKFLEINRTLS-
JSNZ LVTKFLEINRTLSQ
*************
- ↑ Ghassan Ghssein, Catherine Brutesco, Laurent Ouerdane, Clémentine Fojcik, Amélie Izaute, Shuanglong Wang, Christine Hajjar, Ryszard Lobinski, David Lemaire, Pierre Richaud, Romé Voulhoux, Akbar Espaillat, Felipe Cava, David Pignol, Elise Borezée-Durant, Pascal Arnoux
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
Science: 2016, 352(6289);1105-9
[PubMed:27230378] [WorldCat.org] [DOI] (I p)Christine Hajjar, Roberto Fanelli, Clémentine Laffont, Catherine Brutesco, Gregorio Cullia, Mathilde Tribout, Didier Nurizzo, Elise Borezée-Durant, Romé Voulhoux, David Pignol, Jérôme Lavergne, Florine Cavelier, Pascal Arnoux
Control by Metals of Staphylopine Dehydrogenase Activity during Metallophore Biosynthesis.
J Am Chem Soc: 2019, 141(13);5555-5562
[PubMed:30901200] [WorldCat.org] [DOI] (I p)Clémentine Laffont, Catherine Brutesco, Christine Hajjar, Gregorio Cullia, Roberto Fanelli, Laurent Ouerdane, Florine Cavelier, Pascal Arnoux
Simple rules govern the diversity of bacterial nicotianamine-like metallophores.
Biochem J: 2019, 476(15);2221-2233
[PubMed:31300464] [WorldCat.org] [DOI] (I e)