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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006029000
- symbol?: cntL
- synonym:
- description?: D-histidine (S)-2-aminobutanoyltransferase CntL
- D-histidine (S)-2-aminobutanoyltransferase CntL
- Methyltransferase
- nicotianamine synthase
- ribosomal RNA methyltransferase family protein
- rRNA methyltransferase FmrO
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6086246..6087064
- synteny block?: BlockID0047730
- occurrence?: in 100% of 34 strains
cntL : staphylopine biosynthesis D-histidine:S-adenosylmethionine aminobutanoyltransferase [1]
• A crystal structure is available: 7C9M
Staphylococci synthesize the nicotinamide metallophore staphylopine to scavenge trace metals from the environment. CntL transfers the amino acid component of S-adenosylmethionine (alpha-aminobutyrate) to the amino group of D-histidine resulting in a nicotinamide intermediate.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2406
08BA02176:
C248_2519
11819-97:
MS7_2482
6850:
RSAU_002307
71193:
ST398NM01_2519
ECT-R 2:
ECTR2_2326
ED133:
SAOV_2519c
ED98:
SAAV_2535
HO 5096 0412:
SAEMRSA15_23670
JH1:
SaurJH1_2545
JH9:
SaurJH9_2496
JKD6008:
SAA6008_02510 (fmrO)
JKD6159:
SAA6159_02366 (fmrO)
JSNZ:
JSNZ_002444 (cntL)
LGA251:
SARLGA251_22490
M013:
M013TW_2429
MRSA252:
SAR2556
MSHR1132:
SAMSHR1132_22940
MSSA476:
SAS2360
Mu3:
SAHV_2453
Mu50:
SAV2469
MW2:
MW2393
RF122:
SAB2352c
ST398:
SAPIG2519
T0131:
SAT0131_02668 (xerC)
TCH60:
HMPREF0772_10720
TW20:
SATW20_25970
USA300_TCH1516:
USA300HOU_2460
VC40:
SAVC_11215
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNNFNNEIKLILQQYLEKFEAHYERVLQDDQYIEALETLMDDYSEFILNPIYEQQFNAWR
N315 MNNFNNEIKLILQQYLEKFEAHYERVLQDDQYIEALETLMDDYSEFILNPIYEQQFNAWR
NCTC8325 MNNFNNEIKLILQQYLEKFEAHYERVLQDDQYIEALETLMDDYSEFILNPIYEQQFNAWR
Newman MNNFNNEIKLILQQYLEKFEAHYERVLQDDQYIEALETLMDDYSEFILNPIYEQQFNAWR
USA300_FPR3757 MNNFNNEIKLILQQYLEKFEAHYERVLQDDQYIEALETLMDDYSEFILNPIYEQQFNAWR
************************************************************
COL DVEEKAQLIKSLQYITAQCVKQVEVIRARRLLDGQASTTGYFDNIEHCIDEEFGQCSIAS
N315 DVEEKAQLIKSLQYITAQCVKQVEVIRARRLLDGQASTTGYFDNIEHCIDEEFGQCSITS
NCTC8325 DVEEKAQLIKSLQYITAQCVKQVEVIRARRLLDGQASTTGYFDNIEHCIDEEFGQCSIAS
Newman DVEEKAQLIKSLQYITAQCVKQVEVIRARRLLDGQASTTGYFDNIEHCIDEEFGQCSIAS
USA300_FPR3757 DVEEKAQLIKSLQYITAQCVKQVEVIRARRLLDGQASTTGYFDNIEHCIDEEFGQCSIAS
**********************************************************:*
COL NDKLLLVGSGAYPMTLIQVAKETGASVIGIDIDPQAVDLGRRIVNVLAPNEDITITDQKV
N315 NDKLLLVGSGAYPMTLIQVAKETGASVIGIDIDPQAVDLGRRIVNVLAPNEDITITDQKV
NCTC8325 NDKLLLVGSGAYPMTLIQVAKETGASVIGIDIDPQAVDLGRRIVNVLAPNEDITITDQKV
Newman NDKLLLVGSGAYPMTLIQVAKETGASVIGIDIDPQAVDLGRRIVNVLAPNEDITITDQKV
USA300_FPR3757 NDKLLLVGSGAYPMTLIQVAKETGASVIGIDIDPQAVDLGRRIVNVLAPNEDITITDQKV
************************************************************
COL SELKDIKDVTHIIFSSTIPLKYSILEELYDLTNENVVVAMRFGDGIKAIFNYPSQETAED
N315 SELKDIKDVTHIIFSSTIPLKYSILEELYDLTNENVVVAMRFGDGIKAIFNYPSQETAED
NCTC8325 SELKDIKDVTHIIFSSTIPLKYSILEELYDLTNENVVVAMRFGDGIKAIFNYPSQETAED
Newman SELKDIKDVTHIIFSSTIPLKYSILEELYDLTNENVVVAMRFGDGIKAIFNYPSQETAED
USA300_FPR3757 SELKDIKDVTHIIFSSTIPLKYSILEELYDLTNENVVVAMRFGDGIKAIFNYPSQETAED
************************************************************
COL KWQCVNKHMRPQQIFDIALYKKAAIKVGITDV
N315 KWQCVNKHMRPQQIFDIALYKKAAIKVGITDV
NCTC8325 KWQCVNKHMRPQQIFDIALYKKAAIKVGITDV
Newman KWQCVNKHMRPQQIFDIALYKKAAIKVGITDV
USA300_FPR3757 KWQCVNKHMRPQQIFDIALYKKAAIKVGITDV
********************************
- ↑ Ghassan Ghssein, Catherine Brutesco, Laurent Ouerdane, Clémentine Fojcik, Amélie Izaute, Shuanglong Wang, Christine Hajjar, Ryszard Lobinski, David Lemaire, Pierre Richaud, Romé Voulhoux, Akbar Espaillat, Felipe Cava, David Pignol, Elise Borezée-Durant, Pascal Arnoux
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
Science: 2016, 352(6289);1105-9
[PubMed:27230378] [WorldCat.org] [DOI] (I p)Zhiteng Luo, Siting Luo, Yingchen Ju, Peng Ding, Jun Xu, Qiong Gu, Huihao Zhou
Structural insights into the ligand recognition and catalysis of the key aminobutanoyltransferase CntL in staphylopine biosynthesis.
FASEB J: 2021, 35(5);e21575
[PubMed:33826776] [WorldCat.org] [DOI] (I p)