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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006030000
- symbol?: cntK
- synonym:
- description?: diaminopimelate epimerase
- diaminopimelate epimerase
- histidine racemase CntK
- diaminopimelate epimerase-like protein
- diaminopimelate epimerase family protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6087075..6087848
- synteny block?: BlockID0047740
- occurrence?: in 100% of 34 strains
cntK : staphylopine biosynthesis histidine racemase [1]
• A crystal structure is available: 6JIS
Staphylococci synthesize the nicotinamide metallophore staphylopine to scavenge trace metals from the environment. CntK catalyzes the epimerization of L-histidine to generate the staphylopine starter unit D-histidine.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2407
08BA02176:
C248_2520
11819-97:
MS7_2483
6850:
RSAU_002308
71193:
ST398NM01_2520
ECT-R 2:
ECTR2_2327
ED133:
SAOV_2520c
ED98:
SAAV_2536
HO 5096 0412:
SAEMRSA15_23680
JH1:
SaurJH1_2546
JH9:
SaurJH9_2497
JKD6008:
SAA6008_02511 (dapF)
JKD6159:
SAA6159_02367 (dapF)
JSNZ:
JSNZ_002445 (cntK)
LGA251:
SARLGA251_22500
M013:
M013TW_2430
MRSA252:
SAR2557
MSHR1132:
SAMSHR1132_22950
MSSA476:
SAS2361
Mu3:
SAHV_2454
Mu50:
SAV2470
MW2:
MW2394
RF122:
SAB2353c
ST398:
SAPIG2520
T0131:
SAT0131_02669 (hslV)
TCH60:
HMPREF0772_10719 (dapF)
TW20:
SATW20_25980
USA300_TCH1516:
USA300HOU_2461
VC40:
SAVC_11220
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNRQVIEFSKYNPSGNMTILVHSKHDASEYASIANQLMAATHVCCEQVGFIESTQNDDGN
N315 MNRQVIEFSKYNPSGNMTILVHSKHDASEYASIANQLMAATHVCCEQVGFIESTQNDDGN
NCTC8325 MNRQVIEFSKYNPSGNMTILVHSKHDASEYASIANQLMAATHVCCEQVGFIESTQNDDGN
Newman MNRQVIEFSKYNPSGNMTILVHSKHDASEYASIANQLMAATHVCCEQVGFIESTQNDDGN
USA300_FPR3757 MNRQVIEFSKYNPSGNMTILVHSKHDASEYASIANQLMAATHVCCEQVGFIESTQNDDGN
************************************************************
COL DFHLVMSGNEFCGNATMSYIHHLQESHLLKDQQFKVKVSGCSDLVQCAIHDCQYYEVQMP
N315 DFHLVMSGNEFCGNATMSYIHHLQESHLLKDQQFKVKVSGCSDLVQCAIHDCQYYEVQMP
NCTC8325 DFHLVMSGNEFCGNATMSYIHHLQESHLLKDQQFKVKVSGCSDLVQCAIHDCQYYEVQMP
Newman DFHLVMSGNEFCGNATMSYIHHLQESHLLKDQQFKVKVSGCSDLVQCAIHDCQYYEVQMP
USA300_FPR3757 DFHLVMSGNEFCGNATMSYIHHLQESHLLKDQQFKVKVSGCSDLVQCAIHDCQYYEVQMP
************************************************************
COL QAHRVVPTTINMGNHSWKAIEIIYETYVHYVIPVKQVTTEIQHLVEAFVREQQWSHKYKT
N315 QAHRVVPTTINMGNHSWKALEIIYETYVHYVIPVKQVTTEIQHLVEAFVREQQWSHKYKT
NCTC8325 QAHRVVPTTINMGNHSWKAIEIIYETYVHYVIPVKQVTTEIQHLVEAFVREQQWSHKYKT
Newman QAHRVVPTTINMGNHSWKAIEIIYETYVHYVIPVKQVTTEIQHLVEAFVREQQWSHKYKT
USA300_FPR3757 QAHRVVPTTINMGNHSWKAIEIIYETYVHYVIPVKQVTTEIQHLVEAFVREQQWSHKYKT
*******************:****************************************
COL VGMMLFDEQRQFLQPLIYIPEIQSLIWENSCGSGTASIGVFNNYQRNDACKDFTVHQPGG
N315 VGMMLFDEQRQFLQPLIYIPEIQSLIWENSCGSGTASIGVFNNYQRNDACKDFTVHQPGG
NCTC8325 VGMMLFDEQRQFLQPLIYIPEIQSLIWENSCGSGTASIGVFNNYQRNDACKDFTVHQPGG
Newman VGMMLFDEQRQFLQPLIYIPEIQSLIWENSCGSGTASIGVFNNYQRNDACKDFTVHQPGG
USA300_FPR3757 VGMMLFDEQRQFLQPLIYIPEIQSLIWENSCGSGTASIGVFNNYQRNDACKDFTVHQPGG
************************************************************
COL SILVTSKRCHQLGYQTSIKGQVTTVATGKAYIE
N315 SILVTSKRCHQLGYQTSIKGQVTTVATGKAYIE
NCTC8325 SILVTSKRCHQLGYQTSIKGQVTTVATGKAYIE
Newman SILVTSKRCHQLGYQTSIKGQVTTVATGKAYIE
USA300_FPR3757 SILVTSKRCHQLGYQTSIKGQVTTVATGKAYIE
*********************************
- ↑ Ghassan Ghssein, Catherine Brutesco, Laurent Ouerdane, Clémentine Fojcik, Amélie Izaute, Shuanglong Wang, Christine Hajjar, Ryszard Lobinski, David Lemaire, Pierre Richaud, Romé Voulhoux, Akbar Espaillat, Felipe Cava, David Pignol, Elise Borezée-Durant, Pascal Arnoux
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
Science: 2016, 352(6289);1105-9
[PubMed:27230378] [WorldCat.org] [DOI] (I p)Clémentine Laffont, Catherine Brutesco, Christine Hajjar, Gregorio Cullia, Roberto Fanelli, Laurent Ouerdane, Florine Cavelier, Pascal Arnoux
Simple rules govern the diversity of bacterial nicotianamine-like metallophores.
Biochem J: 2019, 476(15);2221-2233
[PubMed:31300464] [WorldCat.org] [DOI] (I e)