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Summary[edit | edit source]

  • pan ID?: SAUPAN006074000
  • symbol?:
  • synonym:
  • description?: hypothetical protein
  • strand?: -
  • coordinates?: 6119316..6119603
  • synteny block?: BlockID0048150
  • occurrence?: in 59% of 34 strains

tlaB2 : phospholipase TslB chaperone and lap secretion-signal protein TlaB2 [1]

Consistent with other LGX toxins secreted by the type VII secretion system, the C-terminal alpha helices of TslB associate with two small helical "LAP" partner proteins (TlaB1 and TlaB2) that function as chaperones and target their partner toxin to the T7SS apparatus.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_2419
    08BA02176:
    11819-97:
    6850:
    RSAU_002321
    71193:
    ECT-R 2:
    ECTR2_2339
    ED133:
    ED98:
    SAAV_2548
    HO 5096 0412:
    SAEMRSA15_23820
    JH1:
    SaurJH1_2561
    JH9:
    SaurJH9_2509
    JKD6008:
    JKD6159:
    SAA6159_02378
    JSNZ:
    JSNZ_002461
    LGA251:
    M013:
    M013TW_2443
    MRSA252:
    MSHR1132:
    MSSA476:
    Mu3:
    SAHV_2466
    Mu50:
    SAV2482
    MW2:
    RF122:
    SAB2365c
    ST398:
    T0131:
    TCH60:
    TW20:
    USA300_TCH1516:
    USA300HOU_2474
    VC40:
    SAVC_11285

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKKF
    N315            MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKNF
    NCTC8325        MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKKF
    Newman          MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKKF
    USA300_FPR3757  MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKKF
                    **********************************************************:*

    COL             EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
    N315            EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
    NCTC8325        EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
    Newman          EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
    USA300_FPR3757  EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
                    ***********************************

  1. Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
    A type VII-secreted lipase toxin with reverse domain arrangement.
    Nat Commun: 2023, 14(1);8438
    [PubMed:38114483] [WorldCat.org] [DOI] (I e)