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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006074000
- symbol?: —
- synonym:
- description?: hypothetical protein
- strand?: -
- coordinates?: 6119316..6119603
- synteny block?: BlockID0048150
- occurrence?: in 59% of 34 strains
tlaB2 : phospholipase TslB chaperone and lap secretion-signal protein TlaB2 [1]
Consistent with other LGX toxins secreted by the type VII secretion system, the C-terminal alpha helices of TslB associate with two small helical "LAP" partner proteins (TlaB1 and TlaB2) that function as chaperones and target their partner toxin to the T7SS apparatus.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2419
08BA02176:
—
11819-97:
—
6850:
RSAU_002321
71193:
—
ECT-R 2:
ECTR2_2339
ED133:
—
ED98:
SAAV_2548
HO 5096 0412:
SAEMRSA15_23820
JH1:
SaurJH1_2561
JH9:
SaurJH9_2509
JKD6008:
—
JKD6159:
SAA6159_02378
JSNZ:
JSNZ_002461
LGA251:
—
M013:
M013TW_2443
MRSA252:
—
MSHR1132:
—
MSSA476:
—
Mu3:
SAHV_2466
Mu50:
SAV2482
MW2:
—
RF122:
SAB2365c
ST398:
—
T0131:
—
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_2474
VC40:
SAVC_11285
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKKF
N315 MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKNF
NCTC8325 MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKKF
Newman MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKKF
USA300_FPR3757 MGLDFSGLPDLAVLEQMKEKEQISEVIAPEHVRMHHDHQNKLKSDEKILLDQMVSHFKKF
**********************************************************:*
COL EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
N315 EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
NCTC8325 EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
Newman EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
USA300_FPR3757 EDDFKNAAQGAWVKNATDELKDISNDLEKIQDIKV
***********************************
- ↑ Stephen R Garrett, Nicole Mietrach, Justin Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement.
Nat Commun: 2023, 14(1);8438
[PubMed:38114483] [WorldCat.org] [DOI] (I e)