From AureoWiki
Jump to navigation Jump to search

Summary[edit | edit source]

  • pan ID?: SAUPAN006366000
  • symbol?: argR1
  • synonym:
  • description?: ArgR family transcriptional regulator

      descriptions from strain specific annotations:

    • ArgR family transcriptional regulator
    • arginine repressor
    • arginine repressor ArgR
    • Arginine pathway regulatory protein ArgR, repressor of arg regulon
    • arginine repressor family protein
    • arginine repressor, C-terminal domain protein
    • arginine repressor, DNA binding domain protein
    • ArgR family transcription regulator
  • strand?: -
  • coordinates?: 6400538..6400987
  • synteny block?: BlockID0050750
  • occurrence?: in 100% of 34 strains

argRc (argRCONS) : constitutive arginine catabolism arginine-binding transcriptional repressor [1]

• this version of ArgR is part of the core staphylococcal genome and is found in all strains. It is part of the arginine deiminase pathway that is actively transcribed only during aerobic growth. The "c" after "argR" is to differentiate this version from the "a" version found in the Arginine Catabolic Metabolic Element (ACME) that sometimes accompanies the SCCmec element in MRSA, particularly the USA300 clade.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    NWMN_2535 (argR)
    USA300_FPR3757:
    04-02981:
    SA2981_2575 (argR)
    08BA02176:
    C248_2704
    11819-97:
    MS7_2641
    6850:
    RSAU_002479 (argR)
    71193:
    ST398NM01_2686
    ECT-R 2:
    ECTR2_2490
    ED133:
    SAOV_2685c
    ED98:
    SAAV_2705
    HO 5096 0412:
    SAEMRSA15_25410
    JH1:
    SaurJH1_2716
    JH9:
    SaurJH9_2660
    JKD6008:
    SAA6008_02695 (argR)
    JKD6159:
    SAA6159_02532 (argR)
    JSNZ:
    JSNZ_002626
    LGA251:
    SARLGA251_24080
    M013:
    M013TW_2617
    MRSA252:
    SAR2715
    MSHR1132:
    SAMSHR1132_24600
    MSSA476:
    SAS2522
    Mu3:
    SAHV_2620
    Mu50:
    SAV2636
    MW2:
    MW2557
    RF122:
    SAB2511c (argR)
    ST398:
    SAPIG2686
    T0131:
    SAT0131_02902
    TCH60:
    HMPREF0772_10551
    TW20:
    SATW20_27740
    USA300_TCH1516:
    USA300HOU_2636 (argR3)
    VC40:
    SAVC_12060

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
    N315            MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
    NCTC8325        MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
    Newman          MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
    USA300_FPR3757  MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
                    ************************************************************

    COL             WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
    N315            WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
    NCTC8325        WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
    Newman          WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
    USA300_FPR3757  WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
                    ************************************************************

    COL             LGTVSGNDTTLILTASNDMAEYVYAKLFK
    N315            LGTVSGNDTTLILTASNDMAEYVYAKLFK
    NCTC8325        LGTVSGNDTTLILTASNDMAEYVYAKLFK
    Newman          LGTVSGNDTTLILTASNDMAEYVYAKLFK
    USA300_FPR3757  LGTVSGNDTTLILTASNDMAEYVYAKLFK
                    *****************************

  1. Julia Makhlin, Tzili Kofman, Ilya Borovok, Christian Kohler, Susanne Engelmann, Gerald Cohen, Yair Aharonowitz
    Staphylococcus aureus ArcR controls expression of the arginine deiminase operon.
    J Bacteriol: 2007, 189(16);5976-86
    [PubMed:17557828] [WorldCat.org] [DOI] (P p)
    Zayda Lorena Corredor Rozo, Ricaurte Alejandro Márquez-Ortiz, Betsy Esperanza Castro, Natasha Vanegas Gómez, Javier Escobar-Pérez
    Participation of the arcRACME protein in self-activation of the arc operon located in the arginine catabolism mobile element in pandemic clone USA300.
    Mem Inst Oswaldo Cruz: 2017, 112(7);499-503
    [PubMed:28591311] [WorldCat.org] [DOI] (I p)