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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006366000
- symbol?: argR1
- synonym:
- description?: ArgR family transcriptional regulator
- ArgR family transcriptional regulator
- arginine repressor
- arginine repressor ArgR
- Arginine pathway regulatory protein ArgR, repressor of arg regulon
- arginine repressor family protein
- arginine repressor, C-terminal domain protein
- arginine repressor, DNA binding domain protein
- ArgR family transcription regulator
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6400538..6400987
- synteny block?: BlockID0050750
- occurrence?: in 100% of 34 strains
argRc (argRCONS) : constitutive arginine catabolism arginine-binding transcriptional repressor [1]
• this version of ArgR is part of the core staphylococcal genome and is found in all strains. It is part of the arginine deiminase pathway that is actively transcribed only during aerobic growth. The "c" after "argR" is to differentiate this version from the "a" version found in the Arginine Catabolic Metabolic Element (ACME) that sometimes accompanies the SCCmec element in MRSA, particularly the USA300 clade.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2575 (argR)
08BA02176:
C248_2704
11819-97:
MS7_2641
6850:
RSAU_002479 (argR)
71193:
ST398NM01_2686
ECT-R 2:
ECTR2_2490
ED133:
SAOV_2685c
ED98:
SAAV_2705
HO 5096 0412:
SAEMRSA15_25410
JH1:
SaurJH1_2716
JH9:
SaurJH9_2660
JKD6008:
SAA6008_02695 (argR)
JKD6159:
SAA6159_02532 (argR)
JSNZ:
JSNZ_002626
LGA251:
SARLGA251_24080
M013:
M013TW_2617
MRSA252:
SAR2715
MSHR1132:
SAMSHR1132_24600
MSSA476:
SAS2522
Mu3:
SAHV_2620
Mu50:
SAV2636
MW2:
MW2557
RF122:
SAB2511c (argR)
ST398:
SAPIG2686
T0131:
SAT0131_02902
TCH60:
HMPREF0772_10551
TW20:
SATW20_27740
USA300_TCH1516:
USA300HOU_2636 (argR3)
VC40:
SAVC_12060
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
N315 MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
NCTC8325 MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
Newman MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
USA300_FPR3757 MKKSKRLEIVSTIVKKHKIYKKEQIISYIEEYFGVRYSATTIAKDLKELNIYRVPIDCET
************************************************************
COL WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
N315 WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
NCTC8325 WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
Newman WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
USA300_FPR3757 WIYKAINNQTEQEMREKFRHYCEHEVLSSIINGSYIIVKTSPGFAQGINYFIDQLNIEEI
************************************************************
COL LGTVSGNDTTLILTASNDMAEYVYAKLFK
N315 LGTVSGNDTTLILTASNDMAEYVYAKLFK
NCTC8325 LGTVSGNDTTLILTASNDMAEYVYAKLFK
Newman LGTVSGNDTTLILTASNDMAEYVYAKLFK
USA300_FPR3757 LGTVSGNDTTLILTASNDMAEYVYAKLFK
*****************************
- ↑ Julia Makhlin, Tzili Kofman, Ilya Borovok, Christian Kohler, Susanne Engelmann, Gerald Cohen, Yair Aharonowitz
Staphylococcus aureus ArcR controls expression of the arginine deiminase operon.
J Bacteriol: 2007, 189(16);5976-86
[PubMed:17557828] [WorldCat.org] [DOI] (P p)Zayda Lorena Corredor Rozo, Ricaurte Alejandro Márquez-Ortiz, Betsy Esperanza Castro, Natasha Vanegas Gómez, Javier Escobar-Pérez
Participation of the arcRACME protein in self-activation of the arc operon located in the arginine catabolism mobile element in pandemic clone USA300.
Mem Inst Oswaldo Cruz: 2017, 112(7);499-503
[PubMed:28591311] [WorldCat.org] [DOI] (I p)