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NCBI: 10-JUN-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus USA300_FPR3757
- locus tag: SAUSA300_0944 [new locus tag: SAUSA300_RS05075 ]
- pan locus tag?: SAUPAN003242000
- symbol: menA
- pan gene symbol?: menA
- synonym:
- product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SAUSA300_0944 [new locus tag: SAUSA300_RS05075 ]
- symbol: menA
- product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase
- replicon: chromosome
- strand: -
- coordinates: 1031928..1032866
- length: 939
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3913662 NCBI
- RefSeq: YP_493642 NCBI
- BioCyc: see SAUSA300_RS05075
- MicrobesOnline: 1292459 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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901ATGAGTAATCAATATCAGCAATATTCTACAGTTAAGAAATATTGGCATTTAATGCGTCCT
CATACATTAACTGCTTCCGTAGTACCCGTTTTAGTTGGTACAGCAGCATCTAAAATATAT
TTTCTTGGTAGCGAAGATCATATTAAAATCAGCCTATTCATTGCCATGTTACTAGCATGC
TTACTTATTCAAGCAGCAACTAATATGTTTAATGAATACTATGATTATAAAAAAGGCCTT
GATGATCATGAATCTGTAGGCATTGGTGGTGCCATTGTTCGCAACGGTATGAGCCCAGAG
CTTGTGCTACGATTAGCCATTGCATTTTACATCTTAGCAGCAATATTAGGTTTGTTTTTA
GCTGCTAACTCTTCATTTTGGTTATTACCAGTTGGATTAGTATGTATGGCTGTTGGTTAC
CTATATACAGGTGGCCCTTTCCCTATTTCATGGACGCCTTTCGGTGAATTATTCTCAGGC
GTATTTATGGGTATGTTTATTATCGTTATTGCATTCTTTATTCAAACTGGCAATATTCAA
AGTTATGTAATTTGGTTAAGTGTACCTATAGTAATCACTATCGGTTTAATTAATATGGCT
AACAATATTCGCGACCGTGTCAAAGATAAAGCAAGTGGTCGCAAAACTTTACCCATTCTA
TTAGGTAAAAATGCTTCTTTAACATTTATGGCAATCATGTACTTTATCGCTTATGCCTTT
ATTGTACTTACGATCATTATTAAACCTGGTGGCTCATTATTTTACTTACTTGCGTTGTTA
TCATTCCCAATGCCTGTTAAAGTTATCAGACGTTTCAAGAAGAATGATACACCGCCTACA
ATGATGCCAGCAATGGCTGCTGCTGGTAAAACAAATACATTTTTCGGTTTATTATATGCA
TTAGGTATTTATATTAGTGCATTATTTGCAGGCATTTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SAUSA300_0944 [new locus tag: SAUSA300_RS05075 ]
- symbol: MenA
- description: 1,4-dihydroxy-2-naphthoate octaprenyltransferase
- length: 312
- theoretical pI: 9.91895
- theoretical MW: 34400
- GRAVY: 0.733654
⊟Function[edit | edit source]
- reaction: EC 2.5.1.74? ExPASy1,4-dihydroxy-2-naphthoate polyprenyltransferase An all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO2
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 1,4-dihydroxy-2-naphthoate octaprenyltransferase (TIGR00751; EC 2.5.1.74; HMM-score: 99.2)Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 1,4-dihydroxy-2-naphthoate phytyltransferase (TIGR02235; EC 2.5.1.-; HMM-score: 98.1)and 2 moreBiosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll chlorophyll synthase ChlG (TIGR02056; EC 2.5.1.62; HMM-score: 23.7)Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone putative 4-hydroxybenzoate polyprenyltransferase (TIGR01475; EC 2.5.1.-; HMM-score: 21.5)
- TheSEED :
- 1,4-dihydroxy-2-naphthoate polyprenyltransferase (EC 2.5.1.74)
Cofactors, Vitamins, Prosthetic Groups, Pigments Quinone cofactors Menaquinone and Phylloquinone Biosynthesis 1,4-dihydroxy-2-naphthoate polyprenyltransferase (EC 2.5.1.74)and 1 more - PFAM: Terp_synthase (CL0613) UbiA; UbiA prenyltransferase family (PF01040; HMM-score: 126.4)and 2 moreno clan defined UPF0767; UPF0767 family (PF15990; HMM-score: 10.6)DAGK_prokar; Prokaryotic diacylglycerol kinase (PF01219; HMM-score: 7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 10
- Cellwall Score: 0
- Extracellular Score: 0
- Internal Helices: 9
- LocateP: Multi-transmembrane
- Prediction by SwissProt Classification: Membrane
- Pathway Prediction: Sec-(SPI)
- Intracellular possibility: 0.17
- Signal peptide possibility: -0.5
- N-terminally Anchored Score: -1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.010098
- TAT(Tat/SPI): 0.000713
- LIPO(Sec/SPII): 0.016984
- predicted transmembrane helices (TMHMM): 9
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MSNQYQQYSTVKKYWHLMRPHTLTASVVPVLVGTAASKIYFLGSEDHIKISLFIAMLLACLLIQAATNMFNEYYDYKKGLDDHESVGIGGAIVRNGMSPELVLRLAIAFYILAAILGLFLAANSSFWLLPVGLVCMAVGYLYTGGPFPISWTPFGELFSGVFMGMFIIVIAFFIQTGNIQSYVIWLSVPIVITIGLINMANNIRDRVKDKASGRKTLPILLGKNASLTFMAIMYFIAYAFIVLTIIIKPGGSLFYLLALLSFPMPVKVIRRFKKNDTPPTMMPAMAAAGKTNTFFGLLYALGIYISALFAGI
⊟Experimental data[edit | edit source]
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: no polycistronic organisation predicted
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
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