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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus USA300_FPR3757
  • locus tag: SAUSA300_1451 [new locus tag: SAUSA300_RS07925 ]
  • pan locus tag?: SAUPAN004035000
  • symbol: SAUSA300_1451
  • pan gene symbol?: —
  • synonym:
  • product: short chain dehydrogenase/reductase family oxidoreductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SAUSA300_1451 [new locus tag: SAUSA300_RS07925 ]
  • symbol: SAUSA300_1451
  • product: short chain dehydrogenase/reductase family oxidoreductase
  • replicon: chromosome
  • strand: -
  • coordinates: 1603938..1604693
  • length: 756
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGAAAGGACAACATTTTATAGTGACTGGTGGTACGAGTGGTTTAGGTTTATCGATTGTC
    CGAAAGTTACTAGAAAATAAAGTGCATGTAACGTTGTTGGTGCGTGATGTTGATAAAGCA
    ACTAGAATCTTTGAACAGGAATTGGGGAAAACTATAAATGTTATTCCTTGTGACTTAAAT
    GATTTGAAGTCGATACAGGCACTGCAATTTGAAGACAATACATCATTCGATGGATTCATT
    TATAGTGCAGGTTTAGGTTATTTCAAATCTATTTCAGACCATAGTTTTTCAGAAATGATT
    GAAACGTATCAGCTTAATTTAATTAGTTTTAATGTTTTATATACTGTGTTGAGACCATAT
    TTAACATCTAACGCACATATTGTAGGTATTTCAAGTCAAGCTGCATTTTCCACACAAGCA
    AATGCTGCACATTATGGGGCATCGAAAGCAGGGTTTTATGCATTAATGAATGCTTTAAGA
    CTAGAGTCACCAAACTTACATATCATGACAGTTAATGTTGGCCCGATTGATACACCTTTT
    CATCAAAAAGCCGACCCATCAATGAAGTATGCTAAAAAGATGGGGGAAATTATGCTTGAT
    GCTAATCAGCTTGCAGAAGATATCATTTATGGCATTAAAACAAAACAATTGGAAATTAAT
    CGGCCTAAATGGATGCATCATGCGTTGAAAATGTATCAAATTGCGCCTAGATTTTTTGAA
    CGATGTTTCCCTAAATTATTTAAAAATAAAGCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    756

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SAUSA300_1451 [new locus tag: SAUSA300_RS07925 ]
  • symbol: SAUSA300_1451
  • description: short chain dehydrogenase/reductase family oxidoreductase
  • length: 251
  • theoretical pI: 9.39542
  • theoretical MW: 28270.5
  • GRAVY: -0.0992032

⊟Function[edit | edit source]

  • TIGRFAM:
    2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (TIGR04316; EC 1.3.1.28; HMM-score: 50.3)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase (TIGR01830; EC 1.1.1.100; HMM-score: 48.3)
    and 14 more
    acetoacetyl-CoA reductase (TIGR01829; EC 1.1.1.36; HMM-score: 39.1)
    sepiapterin reductase (TIGR01500; EC 1.1.1.153; HMM-score: 38.2)
    3-hydroxybutyrate dehydrogenase (TIGR01963; HMM-score: 36.4)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR03971; EC 1.1.99.-; HMM-score: 36.4)
    2-hydroxycyclohexanecarboxyl-CoA dehydrogenase (TIGR03206; EC 1.1.1.-; HMM-score: 35.3)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis putative 3-oxoacyl-(acyl-carrier-protein) reductase (TIGR01831; HMM-score: 31.2)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides 2-deoxy-D-gluconate 3-dehydrogenase (TIGR01832; EC 1.1.1.125; HMM-score: 30.7)
    Metabolism Energy metabolism Fermentation acetoin reductases (TIGR02415; EC 1.1.1.-; HMM-score: 30.7)
    cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (TIGR03325; EC 1.3.1.56; HMM-score: 25.3)
    rhamnulose-1-phosphate aldolase/alcohol dehydrogenase (TIGR02632; EC 1.1.1.1,4.1.2.19; HMM-score: 23)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll light-dependent protochlorophyllide reductase (TIGR01289; EC 1.3.1.33; HMM-score: 20.3)
    hopanoid-associated sugar epimerase (TIGR03466; HMM-score: 13.7)
    Unknown function Enzymes of unknown specificity SDR family mycofactocin-dependent oxidoreductase (TIGR04504; EC 1.1.99.-; HMM-score: 13.5)
    polyketide-type polyunsaturated fatty acid synthase PfaA (TIGR02813; HMM-score: 11.7)
  • TheSEED  :
    • Uncharacterized oxidoreductase YqjQ
  • PFAM:
    NADP_Rossmann (CL0063) adh_short; short chain dehydrogenase (PF00106; HMM-score: 93.5)
    and 8 more
    adh_short_C2; Enoyl-(Acyl carrier protein) reductase (PF13561; HMM-score: 62.5)
    KR; KR domain (PF08659; HMM-score: 41.4)
    NAD_binding_10; NAD(P)H-binding (PF13460; HMM-score: 25.9)
    Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 23.8)
    NmrA; NmrA-like family (PF05368; HMM-score: 18.6)
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family (PF01073; HMM-score: 16.8)
    NAD_binding_4; Male sterility protein (PF07993; HMM-score: 16.7)
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 13.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006837
    • TAT(Tat/SPI): 0.000389
    • LIPO(Sec/SPII): 0.001456
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKGQHFIVTGGTSGLGLSIVRKLLENKVHVTLLVRDVDKATRIFEQELGKTINVIPCDLNDLKSIQALQFEDNTSFDGFIYSAGLGYFKSISDHSFSEMIETYQLNLISFNVLYTVLRPYLTSNAHIVGISSQAAFSTQANAAHYGASKAGFYALMNALRLESPNLHIMTVNVGPIDTPFHQKADPSMKYAKKMGEIMLDANQLAEDIIYGIKTKQLEINRPKWMHHALKMYQIAPRFFERCFPKLFKNKA

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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