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NCBI: 02-MAR-2017

Summary[edit | edit source]

  • organism: Staphylococcus aureus USA300_FPR3757
  • locus tag: SAUSA300_RS13160 [old locus tag: SAUSA300_2379 ]
  • pan locus tag?: SAUPAN005982000
  • symbol: SAUSA300_RS13160
  • pan gene symbol?:
  • synonym:
  • product: Bcr/CflA family drug resistance efflux transporter

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SAUSA300_RS13160 [old locus tag: SAUSA300_2379 ]
  • symbol: SAUSA300_RS13160
  • product: Bcr/CflA family drug resistance efflux transporter
  • replicon: chromosome
  • strand: +
  • coordinates: 2558445..2559656
  • length: 1212
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGCAATCAACGAAAACCAAAACGAAGCATTTTTCATTTTTATTGCTAATTACGTTAGGC
    GTCATGACCGCTTTTGGCCCACTAACTATAGATATGTACGTACCATCATTACCTAAAGTG
    CAAGGTGATTTTGGTTCTACTACATCAGAAATTCAATTAACATTATCATTCACAATGATT
    GGTCTTGCACTAGGCCAATTTATCTTTGGACCTTTATCCGATGCTTTTGGTCGCAAACGG
    ATTGCTGTATCCATTTTGATCATTTTCATTTTGGTATCAGGTTTGTCTATGTTTGTTGAT
    CAATTGCCATTATTCTTAACTTTACGATTTATTCAAGGTTTAACTGGTGGTGGCGTCATC
    GTGATTGCAAAAGCCTCTGCTGGTGATAAATTTAGTGGCAACGCACTCGCTAAATTTTTA
    GCATCTTTAATGGTAGTTAATGGCATCATCACTATTCTTGCACCATTAGCCGGTGGATTA
    GCTTTATCCGTAGCAACATGGCGTTCTATTTTCACAATTTTAACTATTGTGGCACTCATC
    ATTTTAATTGGCGTCGCTTCTCAATTACCTAAAACATCTAAAGATGAATTAAAGCAGGTG
    AATTTTAGTAGCGTCATTAAAGATTTTGGAAGTCTTTTGAAAAAACCAGCATTTATTATT
    CCAATGCTATTACAAGGTTTAACTTATGTAATGCTATTTAGTTATTCATCTGCATCGCCA
    TTTATTACTCAAAAATTGTATAATATGACACCCCAACAATTTAGTATCATGTTTGCTGTT
    AACGGTGTAGGTTTAATCATTGTCAGTCAAGTCGTTGCTTTATTAGTAGAAAAATTACAT
    CGCCACATATTATTAATCATTTTAACTATTATACAAGTGGTAGGTGTTGCTTTAATTATC
    CTGACACTTACATTCCATTTACCACTTTGGGTCTTACTCATCGCATTCTTCTTAAATGTG
    TGTCCTGTGACGTCAATTGGACCGCTTGGTTTCACAATGGCTATGGAAGAACGAACAGGT
    GGCAGTGGTAACGCATCAAGTTTACTTGGCTTATTCCAATTTATCTTAGGTGGCGCTGTT
    GCACCATTAGTTGGCTTAAAAGGCGAATTTAATACATCACCATATATGATTATTATCTTC
    ATTACAGCCATTCTATTAGTCAGTCTACAAATCATTTACTTTAAAATGATTAAAAAGCAA
    CATGTCGCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1212

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SAUSA300_RS13160 [old locus tag: SAUSA300_2379 ]
  • symbol: SAUSA300_RS13160
  • description: Bcr/CflA family drug resistance efflux transporter
  • length: 403
  • theoretical pI: 10.4996
  • theoretical MW: 43450.2
  • GRAVY: 1.00149

Function[edit | edit source]

  • TIGRFAM:
    drug resistance transporter, Bcr/CflA subfamily (TIGR00710; HMM-score: 241.2)
    and 13 more
    multidrug resistance protein (TIGR00880; HMM-score: 66.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids MFS transporter, aromatic acid:H+ symporter (AAHS) family (TIGR00895; HMM-score: 61.6)
    Cellular processes Cellular processes Toxin production and resistance drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 43.1)
    Metabolism Transport and binding proteins Other drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 43.1)
    Metabolism Transport and binding proteins Cations and iron carrying compounds H+ Antiporter protein (TIGR00900; HMM-score: 40)
    Metabolism Transport and binding proteins Unknown substrate MFS transporter, metabolite:H+ symporter (MHS) family protein (TIGR00883; HMM-score: 38.4)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-galactonate transporter (TIGR00893; HMM-score: 33.5)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids MFS transporter, sialate:H+ symporter (SHS) family (TIGR00891; HMM-score: 28.8)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cation transport protein (TIGR00898; HMM-score: 26.7)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids phosphoglycerate transporter family protein (TIGR00881; HMM-score: 26)
    synaptic vesicle protein SV2 (TIGR01299; HMM-score: 19.7)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids sugar (Glycoside-Pentoside-Hexuronide) transporter (TIGR00792; HMM-score: 19.5)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids oxalate/formate antiporter family transporter (TIGR00890; HMM-score: 4.8)
  • TheSEED: see SAUSA300_2379
  • PFAM:
    MFS (CL0015) MFS_1; Major Facilitator Superfamily (PF07690; HMM-score: 132)
    and 3 more
    MFS_2; MFS/sugar transport protein (PF13347; HMM-score: 37.5)
    Sugar_tr; Sugar (and other) transporter (PF00083; HMM-score: 33.8)
    no clan defined DUF5305; Family of unknown function (DUF5305) (PF17231; HMM-score: 7.3)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 12
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.338888
    • TAT(Tat/SPI): 0.007115
    • LIPO(Sec/SPII): 0.091265
  • predicted transmembrane helices (TMHMM): 12

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MQSTKTKTKHFSFLLLITLGVMTAFGPLTIDMYVPSLPKVQGDFGSTTSEIQLTLSFTMIGLALGQFIFGPLSDAFGRKRIAVSILIIFILVSGLSMFVDQLPLFLTLRFIQGLTGGGVIVIAKASAGDKFSGNALAKFLASLMVVNGIITILAPLAGGLALSVATWRSIFTILTIVALIILIGVASQLPKTSKDELKQVNFSSVIKDFGSLLKKPAFIIPMLLQGLTYVMLFSYSSASPFITQKLYNMTPQQFSIMFAVNGVGLIIVSQVVALLVEKLHRHILLIILTIIQVVGVALIILTLTFHLPLWVLLIAFFLNVCPVTSIGPLGFTMAMEERTGGSGNASSLLGLFQFILGGAVAPLVGLKGEFNTSPYMIIIFITAILLVSLQIIYFKMIKKQHVA

Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]