PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA_RS02530 [old locus tag: SA0439 ]
• pan locus tag^?: SAUPAN002215000
• symbol: SA_RS02530
• pan gene symbol^?: —
• synonym:
• product: lysine decarboxylase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS02530 [old locus tag: SA0439 ]
• symbol: SA_RS02530
• product: lysine decarboxylase
• replicon: chromosome
• strand: +
• coordinates: 512201..513538
• length: 1338
• essential: no DEG other strains

⊟Accession numbers

• Location: NC_002745 (512201..513538) NCBI
• BioCyc: SA_RS02530 BioCyc
• MicrobesOnline: see SA0439

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  
  ATGAAGCAACCTATTTTAAATAAATTAGAAAGTTTAAATCAAGAAGAAGCGATTTCTTTG
  CATGTTCCGGGTCATAAAAATATGACTATCGGTCATTTATCTCAATTATCAATGACAATG
  GATAAAACTGAAATACCTGGATTAGATGATTTACATCATCCTGAAGAAGTCATTTTGGAA
  AGTATGAAGCAGGTGGAGAAACATTCAGATTATGATGCTTATTTCTTAGTGAATGGCACC
  ACTTCAGGAATATTATCTGTCATCCAGTCTTTTTCACAGAAAAAAGGCGATATCTTAATG
  GCAAGAAATGTACATAAATCTGTGTTACATGCGCTCGATATTAGCCAACAAGAAGGGCAT
  TTTATTGAAACGCATCAAAGTCCGTTAACGAATCATTATAATAAAGTTAATTTAAGCCGT
  TTGAATAATGACGGTCACAAACTTGCTGTGTTGACTTATCCTAACTATTACGGTGAAACA
  TTTAATGTAGAAGAGGTTATCAAATCTTTGCACCAATTAAATATTCCTGTACTCATTGAC
  GAAGCACACGGCGCGCACTTTGGATTGCAAGGATTTCCAGATTCTACATTAAATTATCAA
  GCTGACTATGTTGTTCAATCTTTTCATAAAACGTTACCAGCTTTAACGATGGGCTCGGTA
  CTTTATATTCATAAAAATGCACCTTATAGAGAAACTATTATAGAATATCTAAGCTACTTC
  CAAACATCTAGTCCTTCGTATTTGATTATGGCTAGTTTAGAGTCAGCTGCCGAGTTCTAT
  AAAACATATGATAGTACCGTGTTTTTTGATAAGAGAGCGCAATTAATCGAATGTTTGGAG
  AAGAAGGGTTTTGAAATGCTTCAAGTTGATGATCCGTTGAAGTTGCTGATAAAATATGAA
  GGTTTTACAGGTCATGATATTCAAAATTGGTTTATGAATGCACATATCTATTTAGAATTA
  GCGGACGACTATCAAGCATTAGCGATATTGCCGTTATGGCATCATGATGATACGTATTTA
  TTTGATTTGCTTTTACGTAAAATTGAAGATATGATTTTACCGAAAAAATCAGTTTCTAAA
  GTTAAACAAACACAACTTTTAACAACTGAAGGTAACTATAAACCAAAACGCTTTGAATAT
  GTTACTTGGTGTGATTTGAAAAAGGCAAAAGGTAAAGTTCTGGCGCGACATATTGTCCCG
  TATCCGCCAGGGATTCCTATTATTTTCAAAGGAGAAACAATAACTGAAAATATGATAGAA
  TTGGTAAATGAATATCTGGAAACTGGAATGATAGTTGAAGGAATTAAAAATAATAAAATT
  TTAGTTGAGGATGAATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1320
  1338
  

⊟Protein

⊟General

• locus tag: SA_RS02530 [old locus tag: SA0439 ]
• symbol: SA_RS02530
• description: lysine decarboxylase
• length: 445
• theoretical pI: 6.02953
• theoretical MW: 51047.1
• GRAVY: -0.285843

⊟Function

• TIGRFAM:
  ornithine decarboxylase SpeF (TIGR04301; EC 4.1.1.17; HMM-score: 29.7)
  O-phospho-L-seryl-tRNA:Cys-tRNA synthase (TIGR02539; EC 2.5.1.73; HMM-score: 29)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, SufS family (TIGR01979; HMM-score: 26.5)
  Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 25.1)
  putative ornithine decarboxylase (TIGR04318; EC 4.1.1.-; HMM-score: 24.8)
  and 2 more
  Unknown function Enzymes of unknown specificity pyridoxal phosphate enzyme, MJ0158 family (TIGR03576; HMM-score: 15.3)
  tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 11.4)
• TheSEED: see SA0439
• PFAM:
  PLP_aminotran (CL0061) OKR_DC_1; Orn/Lys/Arg decarboxylase, major domain (PF01276; HMM-score: 146.2)
  and 3 more
  no clan defined OKR_DC_1_C; Orn/Lys/Arg decarboxylase, C-terminal domain (PF03711; HMM-score: 35)
  PLP_aminotran (CL0061) Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 26.4)
  Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 18.8)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003136
  • TAT(Tat/SPI): 0.000237
  • LIPO(Sec/SPII): 0.000308
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446735573 NCBI
• RefSeq: WP_000812829 NCBI
• UniProt: see SA0439

⊟Protein sequence

• MKQPILNKLESLNQEEAISLHVPGHKNMTIGHLSQLSMTMDKTEIPGLDDLHHPEEVILESMKQVEKHSDYDAYFLVNGTTSGILSVIQSFSQKKGDILMARNVHKSVLHALDISQQEGHFIETHQSPLTNHYNKVNLSRLNNDGHKLAVLTYPNYYGETFNVEEVIKSLHQLNIPVLIDEAHGAHFGLQGFPDSTLNYQADYVVQSFHKTLPALTMGSVLYIHKNAPYRETIIEYLSYFQTSSPSYLIMASLESAAEFYKTYDSTVFFDKRAQLIECLEKKGFEMLQVDDPLKLLIKYEGFTGHDIQNWFMNAHIYLELADDYQALAILPLWHHDDTYLFDLLLRKIEDMILPKKSVSKVKQTQLLTTEGNYKPKRFEYVTWCDLKKAKGKVLARHIVPYPPGIPIIFKGETITENMIELVNEYLETGMIVEGIKNNKILVEDE

⊟Experimental data

• experimentally validated: data available for NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications