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NCBI: 02-MAR-2017

Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS03170 [old locus tag: SA0548 ]
  • pan locus tag?: SAUPAN002372000
  • symbol: SA_RS03170
  • pan gene symbol?: mvaD
  • synonym:
  • product: diphosphomevalonate decarboxylase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SA_RS03170 [old locus tag: SA0548 ]
  • symbol: SA_RS03170
  • product: diphosphomevalonate decarboxylase
  • replicon: chromosome
  • strand: +
  • coordinates: 641677..642660
  • length: 984
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: NC_002745 (641677..642660) NCBI
  • BioCyc: G1G21-622 BioCyc
  • MicrobesOnline:

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    TTGATTAAAAGTGGCAAAGCACGTGCACATACGAATATTGCACTTATAAAATATTGGGGT
    AAAAAAGATGAAGCACTAATCATTCCAATGAATAATAGCATATCTGTTACATTAGAAAAA
    TTTTACACTGAAACGAAAGTCACTTTTAACGACCAGTTAACACAGGATCAATTTTGGTTG
    AATGGTGAAAAGGTTAGTGGCAAAGAATTAGAGAAAATTTCAAAATATATGGATATTGTC
    AGAAATAGAGCTGGCATCGATTGGTATGCTGAAATTGAAAGCGACAATTTTGTACCAACA
    GCAGCAGGGTTGGCTTCATCAGCAAGCGCATATGCAGCTTTAGCAGCAGCTTGTAATCAA
    GCACTAGACTTGCAGCTGTCAGATAAGGATTTATCGAGATTGGCGCGAATTGGTTCGGGT
    TCTGCGTCGCGTAGTATTTATGGTGGATTTGCAGAATGGGAAAAAGGGTATAATGATGAG
    ACGTCATATGCCGTTCCACTTGAATCGAATCATTTTGAAGATGACCTTGCCATGATATTT
    GTTGTGATTAATCAACATTCTAAAAAGGTACCTAGTCGATATGGTATGTCGTTGACACGA
    AACACATCAAGGTTTTATCAATATTGGTTAGATCATATTGATGAAGATTTAGCTGAAGCA
    AAAGCAGCGATTCAAGACAAAGATTTTAAACGCCTTGGTGAAGTAATTGAAGAAAATGGT
    TTACGTATGCATGCCACGAATCTGGGATCAACACCGCCGTTCACTTATCTTGTGCAAGAA
    AGTTATGATGTCATGGCGCTCGTTCACGAATGCCGAGAAGCGGGATATCCGTGTTATTTT
    ACGATGGATGCGGGTCCTAATGTGAAAATACTTGTAGAAAAGAAAAACAAGCAACAGATT
    ATAGATAAATTATTAACACAGTTTGATAATAACCAAATTATTGATAGTGACATTATTGCC
    ACAGGAATTGAAATAATTGAGTAA
    60
    120
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    420
    480
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    720
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    840
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    960
    984

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SA_RS03170 [old locus tag: SA0548 ]
  • symbol: SA_RS03170
  • description: diphosphomevalonate decarboxylase
  • length: 327
  • theoretical pI: 4.83909
  • theoretical MW: 36831.3
  • GRAVY: -0.351376

Function[edit | edit source]

  • TIGRFAM:
    Metabolism Central intermediary metabolism Other diphosphomevalonate decarboxylase (TIGR01240; EC 4.1.1.33; HMM-score: 399.8)
    and 5 more
    Metabolism Central intermediary metabolism Other mevalonate kinase (TIGR00549; EC 2.7.1.36; HMM-score: 45)
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate kinase (TIGR01920; EC 2.7.1.71; HMM-score: 25.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (TIGR00154; EC 2.7.1.148; HMM-score: 17.1)
    Metabolism Amino acid biosynthesis Aspartate family homoserine kinase (TIGR00191; EC 2.7.1.39; HMM-score: 16.9)
    Metabolism Energy metabolism Sugars galactokinase (TIGR00131; EC 2.7.1.6; HMM-score: 16.2)
  • TheSEED:
  • PFAM:
    S5 (CL0329) GHMP_kinases_N; GHMP kinases N terminal domain (PF00288; HMM-score: 31.9)
    no clan defined GHMP_kinases_C; GHMP kinases C terminal (PF08544; HMM-score: 30.2)

Structure, modifications & interactions[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004285
    • TAT(Tat/SPI): 0.000159
    • LIPO(Sec/SPII): 0.000933
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

  • GI: 446519981 NCBI
  • RefSeq: WP_000597327 NCBI
  • UniProt:

Protein sequence[edit | edit source]

  • MIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWLNGEKVSGKELEKISKYMDIVRNRAGIDWYAEIESDNFVPTAAGLASSASAYAALAAACNQALDLQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYNDETSYAVPLESNHFEDDLAMIFVVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENGLRMHATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQIIDKLLTQFDNNQIIDSDIIATGIEIIE

Experimental data[edit | edit source]

  • experimentally validated: no data available

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]