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NCBI: 02-MAR-2017

Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS13370 [old locus tag: SA2333 ]
  • pan locus tag?: SAUPAN006206000
  • symbol: SA_RS13370
  • pan gene symbol?: mvaA
  • synonym:
  • product: hydroxymethylglutaryl-CoA reductase, degradative

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SA_RS13370 [old locus tag: SA2333 ]
  • symbol: SA_RS13370
  • product: hydroxymethylglutaryl-CoA reductase, degradative
  • replicon: chromosome
  • strand: -
  • coordinates: 2617222..2618499
  • length: 1278
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: NC_002745 (2617222..2618499) NCBI
  • BioCyc: G1G21-2715 BioCyc
  • MicrobesOnline:

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGCAAAGTTTAGATAAGAATTTCCGACATTTATCTCGTCAACAAAAGTTACAACAATTG
    GTAGATAAGCAATGGTTATCAGAAGATCAATTCGACATTTTATTGAATCATCCATTAATT
    GATGAGGAAGTAGCAAATAGTTTAATTGAAAATGTCATCGCGCAAGGTGCATTACCCGTT
    GGATTATTACCGAATATCATTGTGGACGATAAGGCATATGTTGTACCTATGATGGTGGAA
    GAGCCTTCAGTTGTCGCTGCAGCTAGTTATGGTGCAAAGCTAGTGAATCAGACTGGCGGA
    TTTAAAACGGTATCTTCTGAACGTATTATGATAGGTCAAATCGTCTTTGATGGCGTTGAC
    GATACTGAAAAATTATCAGCAGACATTAAAGCTTTAGAAAAGCAAATTCATAAAATTGCG
    GATGAGGCATATCCTTCTATTAAAGCGCGTGGTGGTGGTTACCAACGTATAGCTATTGAT
    ACATTTCCTGAGCAACAGTTACTATCTTTAAAAGTATTTGTTGATACGAAAGATGCTATG
    GGCGCTAATATGCTTAATACGATTTTAGAGGCCATAACTGCATTTTTAAAAAATGAATCT
    CCACAAAGCGACATTTTAATGAGTATTTTATCCAATCATGCAACAGCGTCCGTTGTTAAA
    GTTCAAGGCGAAATTGACGTTAAAGATTTAGCAAGGGGCGAGAGAACTGGAGAAGAGGTT
    GCCAAACGAATGGAACGTGCTTCTGTATTGGCACAAGTTGATATTCATCGTGCTGCAACA
    CATAATAAAGGTGTTATGAATGGCATACATGCCGTTGTTTTAGCAACAGGAAATGATACG
    CGTGGTGCAGAAGCAAGTGCGCATGCATACGCGAGTCGTGACGGACAGTATCGTGGTATT
    GCAACATGGAGATACGATCAAAAACGTCAACGTTTAATTGGTACAATAGAAGTGCCTATG
    ACATTGGCAATCGTTGGCGGTGGTACAAAAGTATTACCAATTGCTAAAGCTTCTTTAGAA
    TTGCTAAATGTAGATTCAGCACAAGAATTAGGTCATGTAGTTGCTGCCGTTGGTTTAGCA
    CAGAACTTTGCAGCATGTCGCGCGCTCGTTTCCGAAGGTATCCAGCAAGGCCATATGAGC
    TTGCAATATAAATCTTTAGCTATTGTTGTAGGTGCAAAAGGTGATGAAATTGCGCAAGTA
    GCTGAAGCATTGAAGCAAGAACCCCGTGCGAATACACAAGTAGCTGAACGCATTTTACAA
    GAAATTAGACAACAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
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    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1278

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SA_RS13370 [old locus tag: SA2333 ]
  • symbol: SA_RS13370
  • description: hydroxymethylglutaryl-CoA reductase, degradative
  • length: 425
  • theoretical pI: 6.02407
  • theoretical MW: 46180.5
  • GRAVY: -0.107294

Function[edit | edit source]

  • reaction:
    EC 1.1.1.88?  ExPASy
    Hydroxymethylglutaryl-CoA reductase (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH
  • TIGRFAM:
    Metabolism Energy metabolism Other hydroxymethylglutaryl-CoA reductase, degradative (TIGR00532; EC 1.1.1.88; HMM-score: 330.2)
    and 2 more
    Metabolism Central intermediary metabolism Other hydroxymethylglutaryl-CoA reductase (NADPH) (TIGR00533; EC 1.1.1.34; HMM-score: 61.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids 3-hydroxy-3-methylglutaryl-coenzyme A reductase (TIGR00920; HMM-score: 49.7)
  • TheSEED:
  • PFAM:
    no clan defined HMG-CoA_red; Hydroxymethylglutaryl-coenzyme A reductase (PF00368; HMM-score: 338)
    and 2 more
    UPF0180; Uncharacterised protein family (UPF0180) (PF03698; HMM-score: 16)
    Co_AT_N; Cob(I)alamin adenosyltransferase N terminal (PF12557; HMM-score: 13.5)

Structure, modifications & interactions[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.000944
    • TAT(Tat/SPI): 0.000088
    • LIPO(Sec/SPII): 0.000123
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

  • GI: 447113742 NCBI
  • RefSeq: WP_001190998 NCBI
  • UniProt:

Protein sequence[edit | edit source]

  • MQSLDKNFRHLSRQQKLQQLVDKQWLSEDQFDILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVEEPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAIDTFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNESPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEVAKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGIATWRYDQKRQRLIGTIEVPMTLAIVGGGTKVLPIAKASLELLNVDSAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAQVAEALKQEPRANTQVAERILQEIRQQ

Experimental data[edit | edit source]

  • experimentally validated: no data available

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]