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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 26-AUG-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA0067 [new locus tag: SA_RS00480 ]
  • pan locus tag?: SAUPAN000455000
  • symbol: kdpD
  • pan gene symbol?: kdpD
  • synonym:
  • product: hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA0067 [new locus tag: SA_RS00480 ]
  • symbol: kdpD
  • product: hypothetical protein
  • replicon: chromosome
  • strand: -
  • coordinates: 74179..76812
  • length: 2634
  • essential: no DEG

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    ATTTATTTAGGCTATAGCCCAGGGGTAGGTAAAACGTATGAAATGTTATCAAATGGTATT
    GATCAGTATCAAGAAGGTGCAGATATTAAAATTGGTTATATCGAACCCCATCAACGCCCT
    GAAACCAATGCACTGGTTCAACAATTGCCTGAAATTTCGACCTCCAGCCGTAAATTTGGC
    AGCCACACCTTTCACTATATAGATGTCTCTAAAATCATAGAAGCTAATCCAGATGTGGTC
    TTAATTGATGAACTAGCACATACAAACATTTCAAAAGAGCGCCATTTAAAACGTTATAAG
    GATATAGAAGAAATTCTATCGCATGGTATCGATGTCTGGACAACACTCAACATCCAACAT
    ATCGAGAGTCTAAGCGGACAAATTGCGTTAATGACAGGTATTCAAGTTACAGAACGTGTG
    CCCGACCAATTCATTACGTCAGCAGATGCCTTTGAAGTTGTGGATATTTCACCAAATATG
    TTGATTCAGCGCCTTAAAGCAGGAAAAGTATATAAAAAAGAACGCTTAGAAACAGCCTTT
    TCTAATTTCTTTACGTATGAAAATCTGACAGAGCTGCGTGAACTTACACTCAGAACTGTC
    GCAGATATTATGAGTCAAAAAGGACAACAATATAAAACTAAACATACCGACATTACACCG
    CATATTGCGGTAGCTATCAGCGGCAGTATTTATAACGAACGGGTCATACGAGAAGCAAGA
    CGTGCTGCCTATAAAGAACATGCTAAATTCACAGCTGTGTATATTGATGTCTTTGAGACA
    CCGTCAGAAAGCAGAAAACAAGATCATTATGTCCATAAAAATCTAATGCTCGCCAAAGCG
    TTAGGTGCAGAAATCAAAGTGTTGTATGCACAAGATATTGCGAAAGCGTTAACCGATTGG
    TGTGATCTCGCTTTTGTGACGAAGCTAGTCCTTGGACAGTCAGAACAGCCACGTTGGAAA
    GATTACTTTAAACAGTCACTCATTGAACAAATTAATCACGTACCACACCATTTCAAGTTA
    GAAATTGTACCGATTCATTATATTCATTCAGACAAACCTACAAATACACCTAAGCAAGCT
    CAAAAATCCTCTCGTTTAACTGTAGAGATTATGAAGATGCTTGTAATTCAAACGATCTGT
    GTCTTGCTCGGTATATGGGTTTACAACTTAGATAAAAGCGAATCCAGTGCCATTATCTTG
    CTGATGTTCTTTATCGGTATTATCGTGCTTTCTATTTGGACCCAATCCTATTTAATCGGA
    TTCTTTGCGTCTATCTTAAATGTGTTTGTTTTTAATTATTTCTTTACGGTGCCAAGATTC
    ACTTTAGAAATGTATCGCTTTGAATATCCGATTACGTTTGCGACCAGTATTTTTGCTAGT
    ATCTTTACGAGTGCCATCTTAAAGAATTTAAAACATCAGCATTCCTTAACAGAACGGCAG
    TTATATCGGACCAATATTATGCTGCAATTTAACCAGTCCATTAAAGAATCTTATTCAATT
    GAACGCTTATTAAATATTGCTGGTGATCAGATTCATCAGCTACTCAATCAGGATGTCACG
    GTATTCTTAATTCAAAGTAAGAAAGTCGCTGCTTCCAACTCATTTGGAAACAGAAGCATT
    TCAAGCTCAGATAAGACACATGATGCTGAGACATTGAGCTGGGTCATTGAAAATGAAAGC
    CGTGCCGGTAAATTAACCGATACCTTTCCTGGCAGTAAATTTTTGTGTATTCCCATTGGC
    ACAAATCCAGTCAAAGGTGTGATTTCTATCCGCTTCACCGACGAAACTTACATCGACACC
    TATGACAATTCAATATTAGACTCTATGTTGAACGATATTACCCTGGCAATAGAGAATGTG
    GATCTATTAAAACAAACCAGACAATCCATATTGAAAGCTGAACGAGAAGCCACACGTTCA
    AACTTCTTGCATTCAATTTCACATGATATTAGAACACCACTGACTTCCATTATGGGCAAC
    TTAGATATGCTGAAATACCATAACGAGCATTTAAACGATCAACAACAAGCAGAACTCTTA
    ACTGCTTCTTATGGCGAAGCACAATATCTGCATACCTTAGTCACAAATATTTTATCTTTG
    ACTAAGTTAGAAAGCTCTGACATTCAAATACAACGCACCCCTTATTTAGTAGAAGAACTT
    CTAGAAGAATTTGAAGAAGGCCTCATACGCAGACACCAAGCAAATCATGTCATTATTGAA
    AATGAGGATGACGCTTCACTCATTAATATCGACAGTAAATTAATACTGCAAGTGCTATTC
    AACCTTATCGATAATGCTTTAAAGCATGCAGAATCACATTCTGAAATAAAACTGCACGTT
    CAACATGAAACAAACAAAATAAAATTCGAAATGATAGATTGCGGAAAAGGTATTCCAGAA
    GAAGAACGTCAATTGATTTTTAATCCCTATTATTCAGGAGACAACTTTAAAGACAATAAA
    AAAGATAGTTTGGGATTAGGGCTCTATTTAGTACAACTCATCTTGAAACAACACAACAGT
    GAATTAGAATATCAACCGAATACACCACAAGGCAGTATTTTTTATTTTTATTTGACTGTT
    AATCCAATTGAAATGGAGGGAGCCATGGATGAAAACAACATTATTGGTCGTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2634

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA0067 [new locus tag: SA_RS00480 ]
  • symbol: KdpD
  • description: hypothetical protein
  • length: 877
  • theoretical pI: 6.18311
  • theoretical MW: 100610
  • GRAVY: -0.230673

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 135.1)
    Signal transduction Signal transduction Two-component systems TMAO reductase sytem sensor TorS (TIGR02956; EC 2.7.13.3; HMM-score: 123.4)
    and 6 more
    heavy metal sensor kinase (TIGR01386; EC 2.7.13.3; HMM-score: 96.6)
    proteobacterial dedicated sortase system histidine kinase (TIGR03785; HMM-score: 78.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 46.3)
    Signal transduction Signal transduction Two-component systems putative PEP-CTERM system histidine kinase (TIGR02916; EC 2.7.13.3; HMM-score: 46.3)
    Metabolism Central intermediary metabolism Nitrogen fixation nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 40.2)
    Signal transduction Regulatory functions Protein interactions nitrogen fixation negative regulator NifL (TIGR02938; HMM-score: 40.2)
  • TheSEED  :
    • Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)
    Potassium metabolism Potassium metabolism - no subcategory Potassium homeostasis  Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)
  • PFAM:
    P-loop_NTPase (CL0023) KdpD; Osmosensitive K+ channel His kinase sensor domain (PF02702; HMM-score: 260.5)
    and 7 more
    no clan defined DUF4118; Domain of unknown function (DUF4118) (PF13493; HMM-score: 73.1)
    His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 63.7)
    HisKA; His Kinase A (phospho-acceptor) domain (PF00512; HMM-score: 51.8)
    HATPase_c_5; GHKL domain (PF14501; HMM-score: 21.6)
    HATPase_c_2; Histidine kinase-like ATPase domain (PF13581; HMM-score: 15.7)
    no clan defined PHO4; Phosphate transporter family (PF01384; HMM-score: 14.1)
    EI24; Etoposide-induced protein 2.4 (EI24) (PF07264; HMM-score: 12.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005532
    • TAT(Tat/SPI): 0.000451
    • LIPO(Sec/SPII): 0.00134
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MYLGYSPGVGKTYEMLSNGIDQYQEGADIKIGYIEPHQRPETNALVQQLPEISTSSRKFGSHTFHYIDVSKIIEANPDVVLIDELAHTNISKERHLKRYKDIEEILSHGIDVWTTLNIQHIESLSGQIALMTGIQVTERVPDQFITSADAFEVVDISPNMLIQRLKAGKVYKKERLETAFSNFFTYENLTELRELTLRTVADIMSQKGQQYKTKHTDITPHIAVAISGSIYNERVIREARRAAYKEHAKFTAVYIDVFETPSESRKQDHYVHKNLMLAKALGAEIKVLYAQDIAKALTDWCDLAFVTKLVLGQSEQPRWKDYFKQSLIEQINHVPHHFKLEIVPIHYIHSDKPTNTPKQAQKSSRLTVEIMKMLVIQTICVLLGIWVYNLDKSESSAIILLMFFIGIIVLSIWTQSYLIGFFASILNVFVFNYFFTVPRFTLEMYRFEYPITFATSIFASIFTSAILKNLKHQHSLTERQLYRTNIMLQFNQSIKESYSIERLLNIAGDQIHQLLNQDVTVFLIQSKKVAASNSFGNRSISSSDKTHDAETLSWVIENESRAGKLTDTFPGSKFLCIPIGTNPVKGVISIRFTDETYIDTYDNSILDSMLNDITLAIENVDLLKQTRQSILKAEREATRSNFLHSISHDIRTPLTSIMGNLDMLKYHNEHLNDQQQAELLTASYGEAQYLHTLVTNILSLTKLESSDIQIQRTPYLVEELLEEFEEGLIRRHQANHVIIENEDDASLINIDSKLILQVLFNLIDNALKHAESHSEIKLHVQHETNKIKFEMIDCGKGIPEEERQLIFNPYYSGDNFKDNKKDSLGLGLYLVQLILKQHNSELEYQPNTPQGSIFYFYLTVNPIEMEGAMDENNIIGR

⊟Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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