NCBI: 02-MAR-2017
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus USA300_FPR3757
- locus tag: SAUSA300_RS13855 [old locus tag: SAUSA300_2494 ]
- pan locus tag?: SAUPAN006220000
- symbol: SAUSA300_RS13855
- pan gene symbol?: copA
- synonym:
- product: copper-exporting P-type ATPase A
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SAUSA300_RS13855 [old locus tag: SAUSA300_2494 ]
- symbol: SAUSA300_RS13855
- product: copper-exporting P-type ATPase A
- replicon: chromosome
- strand: +
- coordinates: 2696542..2698950
- length: 2409
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Location: NC_007793 (2696542..2698950) NCBI
- BioCyc: SAUSA300_RS13855 BioCyc
- MicrobesOnline: see SAUSA300_2494
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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2401GTGGCTAATACGAAAAAAACAACATTAGATATCACTGGTATGACTTGTGCCGCATGTTCA
AATCGTATCGAAAAGAAACTGAATAAACTTGATGACGTTAATGCCCAAGTGAATTTAACT
ACAGAGAAAGCAACTGTTGAGTATAACCCTGATCAACATGATGTCCAAGAATTTATTAAT
ACGATTCAACATTTAGGTTACGGTGTCGCTGTAGAAACTGTCGAATTAGACATTACAGGT
ATGACTTGTGCTGCATGCTCAAGCCGTATTGAAAAAGTGTTAAATAAAATGGACGGCGTT
CAAAATGCAACGGTCAATTTAACAACAGAGCAAGCTAAAGTTGACTATTATCCTGAAGAA
ACAGATGCTGATAAACTTGTCACTCGCATTCAAAAATTAGGTTATGACGCGTCTATTAAA
GATAACAATAAAGATCAAACGTCACGCAAAGCTGAAGCGCTACAACATAAATTGATTAAG
CTTATCATATCAGCAGTATTATCTTTACCACTATTAATGTTAATGTTTGTACATCTTTTC
AATATGCATATACCAGCACTATTTACGAATCCATGGTTCCAATTTATTTTAGCTACACCT
GTACAATTTATTATTGGATGGCAATTTTATGTAGGTGCTTATAAAAACTTAAGAAATGGT
GGCGCCAATATGGATGTACTTGTTGCTGTTGGTACAAGTGCAGCATATTTTTACAGTATT
TATGAAATGGTTCGTTGGCTAAATGGCTCAACAACGCAACCGCATTTATACTTTGAAACA
AGCGCCGTACTAATTACCTTAATCTTATTCGGTAAGTATTTAGAAGCTAGAGCGAAGTCT
CAAACAACCAATGCGCTTGGCGAATTATTAAGTTTACAAGCTAAAGAAGCACGCATTTTA
AAAGATGGTAATGAAGTGATGATTCCTCTAAATGAAGTACATGTTGGAGATACACTTATC
GTTAAACCAGGTGAAAAGATACCTGTTGATGGCAAAATTATTAAAGGTATGACTGCCATC
GACGAATCTATGTTAACAGGTGAATCTATCCCTGTTGAGAAGAATGTTGATGATACTGTA
ATTGGTTCAACGATGAACAAAAACGGTACTATTACTATGACAGCAACAAAAGTTGGCGGG
GACACTGCGTTGGCAAATATTATTAAAGTTGTCGAAGAAGCTCAAAGTTCTAAAGCGCCG
ATTCAACGATTGGCAGATATTATTTCTGGTTATTTCGTTCCTATCGTTGTTGGTATCGCA
CTATTAACATTTATCGTGTGGATTACTTTAGTTACACCAGGTACATTTGAACCTGCACTT
GTTGCGAGTATTTCCGTTCTCGTCATTGCTTGTCCATGCGCATTGGGACTTGCTACACCA
ACTTCTATTATGGTAGGTACTGGTCGCGCTGCTGAAAATGGTATTTTATTTAAAGGTGGC
GAGTTTGTTGAACGCACACATCAAATTGATACCATCGTTTTAGATAAGACGGGTACCATT
ACAAATGGTCGTCCAGTCGTGACAGATTATCATGGTGACAATCAAACGCTACAACTACTT
GCTACTGCTGAAAAAGATTCTGAACACCCATTGGCAGAAGCCATTGTCAATTATGCAAAA
GAAAAGCAATTAATATTAACTGAGACAACAACATTTAAAGCAGTACCTGGCCATGGTATT
GAAGCAACGATTGATCATCACTATATATTGGTTGGTAACCGTAAATTAATGGCTGACAAT
GATATTAGCTTGCCTAAGCATATTTCTGATGATTTAACACATTATGAACGAGATGGTAAA
ACTGCTATGCTCATTGCTGTTAATTATTCATTAACTGGTATCATCGCAGTGGCAGATACT
GTCAAAGATCATGCCAAAGATGCTATAAAACAATTGCATGATATGGGCATTGAAGTTGCC
ATGTTAACTGGCGATAATAAAAACACTGCTCAAGCCATTGCAAAACAAGTAGGCATAGAT
ACTGTTATTGCAGATATTTTACCAGAAGAAAAAGCTGCACAAATTGCGAAACTACAGCAA
CAAGGTAAGAAGGTTGCGATGGTTGGTGACGGTGTAAATGATGCACCTGCATTAGTTAAA
GCTGATATCGGTATCGCCATTGGTACAGGTACAGAAGTTGCCATTGAAGCAGCTGATATT
ACTATTCTTGGTGGCGACTTGATGCTTATTCCTAAAGCCATTTATGCAAGTAAAGCAACC
ATTCGTAATATTCGTCAAAATCTATTTTGGGCATTCGGCTATAATATTGCCGGTATCCCT
ATAGCTGCATTGGGCTTACTTGCGCCATGGGTTGCTGGTGCTGCAATGGCACTAAGTTCA
GTAAGTGTTGTCACAAACGCACTTAGATTGAAAAAGATGCGATTAGAACCACGCCGTAAA
GATGCCTAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SAUSA300_RS13855 [old locus tag: SAUSA300_2494 ]
- symbol: SAUSA300_RS13855
- description: copper-exporting P-type ATPase A
- length: 802
- theoretical pI: 6.08194
- theoretical MW: 86769.8
- GRAVY: 0.10985
⊟Function[edit | edit source]
- ⊞reaction: EC 3.6.3.54? ExPASy
- ⊞TIGRFAM: heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 670.8)Cellular processes Detoxification copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 632.8)Transport and binding proteins Cations and iron carrying compounds copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 632.8)and 31 more
- TheSEED: see SAUSA300_2494
- ⊞PFAM: no clan defined E1-E2_ATPase; E1-E2 ATPase (PF00122; HMM-score: 192.8)HAD (CL0137) Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 168.9)and 8 more
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
⊟Accession numbers[edit | edit source]
- GI: 445946273 NCBI
- RefSeq: WP_000024128 NCBI
- UniProt: see SAUSA300_2494
⊟Protein sequence[edit | edit source]
- MANTKKTTLDITGMTCAACSNRIEKKLNKLDDVNAQVNLTTEKATVEYNPDQHDVQEFINTIQHLGYGVAVETVELDITGMTCAACSSRIEKVLNKMDGVQNATVNLTTEQAKVDYYPEETDADKLVTRIQKLGYDASIKDNNKDQTSRKAEALQHKLIKLIISAVLSLPLLMLMFVHLFNMHIPALFTNPWFQFILATPVQFIIGWQFYVGAYKNLRNGGANMDVLVAVGTSAAYFYSIYEMVRWLNGSTTQPHLYFETSAVLITLILFGKYLEARAKSQTTNALGELLSLQAKEARILKDGNEVMIPLNEVHVGDTLIVKPGEKIPVDGKIIKGMTAIDESMLTGESIPVEKNVDDTVIGSTMNKNGTITMTATKVGGDTALANIIKVVEEAQSSKAPIQRLADIISGYFVPIVVGIALLTFIVWITLVTPGTFEPALVASISVLVIACPCALGLATPTSIMVGTGRAAENGILFKGGEFVERTHQIDTIVLDKTGTITNGRPVVTDYHGDNQTLQLLATAEKDSEHPLAEAIVNYAKEKQLILTETTTFKAVPGHGIEATIDHHYILVGNRKLMADNDISLPKHISDDLTHYERDGKTAMLIAVNYSLTGIIAVADTVKDHAKDAIKQLHDMGIEVAMLTGDNKNTAQAIAKQVGIDTVIADILPEEKAAQIAKLQQQGKKVAMVGDGVNDAPALVKADIGIAIGTGTEVAIEAADITILGGDLMLIPKAIYASKATIRNIRQNLFWAFGYNIAGIPIAALGLLAPWVAGAAMALSSVSVVTNALRLKKMRLEPRRKDA
⊟Experimental data[edit | edit source]
- experimentally validated: data available for COL, NCTC8325
- protein localization: data available for COL
- quantitative data / protein copy number per cell:
- ⊟interaction partners:
SAUSA300_RS03530 LysR family transcriptional regulator [1] (data from MRSA252) SAUSA300_RS04100 enolase [1] (data from MRSA252) SAUSA300_RS12065 30S ribosomal protein S5 [1] (data from MRSA252)
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊞Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊞Other Information[edit | edit source]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Jump up to: 1.0 1.1 1.2 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
J Proteome Res: 2011, 10(3);1139-50
[PubMed:21166474] [WorldCat.org] [DOI] (I p)