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NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_0981 [new locus tag: NWMN_RS05495 ]
  • pan locus tag?: SAUPAN003343000
  • symbol: cyoD
  • pan gene symbol?: ctaB
  • synonym:
  • product: protoheme IX farnesyltransferase

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_0981 [new locus tag: NWMN_RS05495 ]
  • symbol: cyoD
  • product: protoheme IX farnesyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 1090462..1091373
  • length: 912
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGAGCAAAGAGCATACTTTGTCACAAAATATTAGCAGAGTTAACTTCAAAGAATTGCAA
    CAGATAATTAAAATGGGACTTGTTCAAGGTAACTTAATTCCGGCTTTTGCGGGCGCATGG
    CTAGCAGTTGTAATGACAAATCATTCCTTCTTATCATCAATACCTCAAATTTTATTAATG
    CTATTTGGATCTACTTTAATTATGGGTGGCGCATGTGCGTTAAATAATTATTACGACCAA
    GATATTGATCGTATTATGCCTAGTAAACAAAATAGACCAACTGTAAATAATAGAATTACA
    GATCAAAATTTATTACTATTAAGTTTTGGTATGATGTTAGTTGGAGAAATTTGTTTGTTT
    TTATTGAATATACCATCAGGCGTACTTGGTCTTATGGGGATTGTAGGTTATGTGTCTTAT
    TACTCAATATGGTCTAAAAGACATACAACATGGAACACAGTGATTGGGAGTTTTCCTGGA
    GCAGTACCACCACTAATTGGATGGGTTGCAATTGAAGGACAAATTAGTTTAACAGCGATT
    GCGCTGTTTTTAGTTGTATTTTGTTGGCAACCAATTCATTTTTATGCCTTAGCTATTAAA
    CGTAAAGATGAATATGCACTTGCAAATATTCCAATGTTACCATCAGTTAAGGGCTTTAAA
    CGTACACGTGTCAGTATGTTTATCTGGTTGATTATTTTATTGCCAGTACCTTTATTACTA
    ATAAATTTAGGTGTCGTATTCGTAGTGTTAGCTACATTATTAAATTTAGGATGGATTGCA
    TTAGGTTTAACAACATTTAAGAAAAATTCAGATCAAACAAAATGGGCAACACAAATGTTT
    ATATATTCACTAAATTATTTAGTGATCTTTTTCGTGTTAGCTGTGATTGTTTCATTACTT
    ACTTTGATCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    912

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_0981 [new locus tag: NWMN_RS05495 ]
  • symbol: CyoD
  • description: protoheme IX farnesyltransferase
  • length: 303
  • theoretical pI: 9.93909
  • theoretical MW: 33858.4
  • GRAVY: 0.735644

Function[edit source | edit]

  • reaction:
    EC 2.5.1.-?  ExPASy
  • TIGRFAM:
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersHeme, porphyrin, and cobalaminprotoheme IX farnesyltransferase (TIGR01473; EC 2.5.1.-; HMM-score: 318.5)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersMenaquinone and ubiquinone4-hydroxybenzoate polyprenyl transferase (TIGR01474; EC 2.5.1.-; HMM-score: 62.2)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersMenaquinone and ubiquinoneputative 4-hydroxybenzoate polyprenyltransferase (TIGR01475; EC 2.5.1.-; HMM-score: 39.1)
  • TheSEED:  
    RespirationRespiration - no subcategoryBiogenesis of cytochrome c oxidases Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB 
    Stress ResponseStress Response - no subcategoryFlavohaemoglobin Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB 
    CBSS-316057.3.peg.563 Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB 
  • PFAM:
    Terp_synthase (CL0613) UbiA; UbiA prenyltransferase family (PF01040; HMM-score: 189.5)
    no clan definedTrbL; TrbL/VirB6 plasmid conjugal transfer protein (PF04610; HMM-score: 19)
    DUF4577; Domain of unknown function (DUF4577) (PF15145; HMM-score: 12.7)
    DUF3671; Protein of unknown function (PF12420; HMM-score: 7.5)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 9
  • LocateP: Multi-transmembrane(Lipid modified N-termini)
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPII)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: MGGACAL
  • SignalP: no predicted signal peptide
    • Ymax: 0.144
    • Ymax_pos: 38
    • Cmax: 0.115
    • Cmax_pos: 52
    • Smax: 0.25
    • Smax_pos: 27
    • Smean: 0.137
    • D: 0.141
  • predicted transmembrane helices (TMHMM): 8

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLMLFGSTLIMGGACALNNYYDQDIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLFLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFPGAVPPLIGWVAIEGQISLTAIALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLLLINLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLLTLI

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]