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NCBI: 06-JUL-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_2340 [new locus tag: NWMN_RS13480 ]
  • pan locus tag?: SAUPAN005992000
  • symbol: NWMN_2340
  • pan gene symbol?: flp
  • synonym:
  • product: fmtA-like beta-lactam resistance protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_2340 [new locus tag: NWMN_RS13480 ]
  • symbol: NWMN_2340
  • product: fmtA-like beta-lactam resistance protein
  • replicon: chromosome
  • strand: +
  • coordinates: 2572937..2574433
  • length: 1497
  • essential: unknown other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGACTACTAAAAAACTGTATTTTCTATCCATTTCTATTATCATTTTAGTCGCCATTTCA
    ATTGCTATATATATAACATTAAATAGCAATACGAAGACACGGTTAACCAATGATTCGCAA
    CAACAAATAGATACAATTATCGAGCATGATTTACAAAAGGGACACATTCCTGGAGCATCA
    ATTTTAATAGTAAAAAATGGCAAAGTTTTTTTAAATAAAGGTTATGGTTATCAAGATGTT
    GATAAAAAAGTCAAAGCTTCTCCCACAACAAAGTATGAAATTGCTTCTAATACGAAAGCT
    TTCACAGGTCTTGCAATTTTAAAATTAGCTCAAGAAGGTCGATTAAACTTAAATGATGCC
    GTATCCAAACATGTGCCTCATTTTAAAATGAACTATAATGGTCAAAATGAAACTATTACG
    ATTAAGCAACTTTTGGCTCAAACAAGTGGTATACCTAGTGATATTACAAGCGAAGATTCT
    GTGACAAGCAAAAATAATCGTTTAAATGATGTAACCCGTGCAATTATGGGTGATGAATTA
    CATCATAAGCCCGGAGAAGAATTTGAATACTCAAATATGAACTATGATTTATTAGGTTTA
    ATTATCCAAAACGTTACGAAGCAATCCTATACAAAATATATTACAAATTCATGGCTCAAG
    CCTTTGCATATGACACATACATCATTCAAACAAACCAATTACAAATCAAAACATGATGCT
    ATTGGCTATGAATTACAAGGTTCGACACCTGTCGTCTCTAAACCTGAATTTAACCTTTGG
    GATACACCATCAGCATATATGATGACATCAACTGAAGATTTGGAACATTGGATAAAATTC
    CAACTTAATCCACCTGATAAATACAAATCATTAGTTCAACAATCACATAAAAATTTATCT
    TCAACAATTGGTGAACCTAATGCCAATGCATATGCTTCCGGCTGGTTTACCAATAATGAT
    GAACATTTAGTGTTTCATTCAGGAACGCTAGATAACTTTTCATCATTTATTTTACTAAAT
    CCAAAACAAAATTATGGAATTGTTGTACTTGCAAATCTAAATTCGGAATATGTACCCAAA
    TTAGTTGAGCATCTTAATACACAAATTGTAAATCACAAGCGATATTCGACGGTTGCGTCT
    ATGCTCAATCAATATAAAGATCAATTTAATATTGTTACCGTTTTGATGACAACACTTATT
    TTATTAGCATTTATATTCTCAGCTTATCGTGCTTGGCAAATGCGCCATGGTCAAATTCTT
    TTGCGTAGATCAAAACGGATTGCTGTATTGAGTTGGTTATCATTATGTATATGTATCGCT
    TTAGCGCTCATATTATATGCATTACCATATCTCATTCTCGGTAGCAATAATTGGTCTTTT
    GTACTGACTTGGCTACCAATAGAAATTAAATTAGCACTAATCACAACATTAATTGCATTA
    TTCAGTACATTAATTGTAATTCTGTTATTCCTTCATACAAAGATAACGAAGACATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1497

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_2340 [new locus tag: NWMN_RS13480 ]
  • symbol: NWMN_2340
  • description: fmtA-like beta-lactam resistance protein
  • length: 498
  • theoretical pI: 9.65027
  • theoretical MW: 56466.8
  • GRAVY: -0.0746988

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
  • TheSEED:  
    Virulence, Disease and DefenseResistance to antibiotics and toxic compoundsBeta-lactamase Beta-lactamase (EC 3.5.2.6) 
  • PFAM:
    Beta-lactamase (CL0013) Beta-lactamase; Beta-lactamase (PF00144; HMM-score: 235.1)
    GPCR_A (CL0192) 7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR (PF00003; HMM-score: 17.1)
    no clan definedSIT; SHP2-interacting transmembrane adaptor protein, SIT (PF15330; HMM-score: 10.9)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular Possibility: 0.17
    • Signal Peptide Possibility: 0
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.275
    • Ymax_pos: 25
    • Cmax: 0.23
    • Cmax_pos: 25
    • Smax: 0.566
    • Smax_pos: 1
    • Smean: 0.361
    • D: 0.308
  • predicted transmembrane helices (TMHMM): 4

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MTTKKLYFLSISIIILVAISIAIYITLNSNTKTRLTNDSQQQIDTIIEHDLQKGHIPGASILIVKNGKVFLNKGYGYQDVDKKVKASPTTKYEIASNTKAFTGLAILKLAQEGRLNLNDAVSKHVPHFKMNYNGQNETITIKQLLAQTSGIPSDITSEDSVTSKNNRLNDVTRAIMGDELHHKPGEEFEYSNMNYDLLGLIIQNVTKQSYTKYITNSWLKPLHMTHTSFKQTNYKSKHDAIGYELQGSTPVVSKPEFNLWDTPSAYMMTSTEDLEHWIKFQLNPPDKYKSLVQQSHKNLSSTIGEPNANAYASGWFTNNDEHLVFHSGTLDNFSSFILLNPKQNYGIVVLANLNSEYVPKLVEHLNTQIVNHKRYSTVASMLNQYKDQFNIVTVLMTTLILLAFIFSAYRAWQMRHGQILLRRSKRIAVLSWLSLCICIALALILYALPYLILGSNNWSFVLTWLPIEIKLALITTLIALFSTLIVILLFLHTKITKT

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • NWMN_2340 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]