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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS06455 [old locus tag: NWMN_1144 ]
  • pan locus tag?: SAUPAN003521000
  • symbol: NWMN_RS06455
  • pan gene symbol?: smc
  • synonym:
  • product: chromosome segregation protein SMC

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_RS06455 [old locus tag: NWMN_1144 ]
  • symbol: NWMN_RS06455
  • product: chromosome segregation protein SMC
  • replicon: chromosome
  • strand: +
  • coordinates: 1252729..1256295
  • length: 3567
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_009641 (1252729..1256295) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
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    ATGGTTTATTTAAAATCAATAGATGCCATTGGATTTAAGTCTTTTGCAGATCAAACCAAT
    GTTCAATTCGATAAAGGTGTAACTGCAATTGTTGGTCCAAATGGAAGCGGTAAAAGTAAT
    ATTACAGATGCTATTAAATGGGTGTTGGGTGAACAATCGGCTAAATCATTACGTGGCTCA
    AAAATGGAAGATATTATCTTCTCAGGTGCAGAACATCGCAAAGCTCAAAATTATGCTGAA
    GTACAGTTAAGATTAGATAATCATTCTAAAAAGCTCAGTGTTGATGAAAACGAAGTTATT
    GTAACAAGAAGATTGTATCGAAGTGGTGAAAGTGAGTACTACATAAATAATGACCGTGCA
    AGATTAAAAGATATTGCCGATTTATTTTTAGATTCTGGATTGGGAAAAGAAGCGTATAGC
    ATTATCTCGCAAGGTAGAGTTGATGAAATACTAAATGCTAAACCAATTGATAGACGTCAA
    ATTATTGAAGAATCGGCTGGTGTACTTAAATATAAAAAACGTAAGGCTGAATCATTAAAT
    AAACTTGACCAAACAGAAGATAATTTAACGAGAGTAGAAGACATTTTATATGATTTGGAA
    GGTCGCGTAGAACCTCTAAAAGAGGAGGCAGCTATAGCTAAAGAATATAAGACACTTTCA
    CATCAAATGAAACATAGTGACATTGTAGTTACAGTGCACGATATTGATCAATATACAAAT
    GACAATAGACAATTAGATCAACGTTTAAATGATTTACAAGGCCAACAAGCAAATAAAGAA
    GCTGACAAGCAACGTTTAAGCCAACAAATTCAACAATATAAAGGTAAACGTCATCAACTT
    GATAATGATGTTGAATCGCTTAATTATCAATTAGTAAAAGCTACGGAAGCCTTTGAAAAA
    TATACGGGACAATTAAATGTTTTGGAAGAACGTAAGAAAAATCAATCTGAAACAAATGCA
    CGATATGAAGAAGAACAAGAAAATTTAATGGAGCTTTTAGAAAATATATCAAATGAGATT
    TCTGAAGCTCAAGATACTTATAAGTCTCTGAAAAGTAAACAAAAAGAACTCAATGCTGTC
    ATTCGTGAACTTGAAGAACAACTATATGTTTCAGACGAAGCACATGATGAAAAATTGGAA
    GAAATTAAAAACGAATACTATACATTAATGTCAGAGCAATCAGATGTTAACAATGATATT
    CGTTTTTTAAAGCATACTATAGAAGAGAATGAGGCTAAAAAATCAAGACTAGATTCTCGA
    TTAGTTGAAGTTTTTGAGCAATTGAAAGATATTCAGGGTCAAATAAAAACGACAAAAAAA
    GAATATCAACAGACCAACAAAGAACTTTCTGCTGTAGATAAAGAAATTAAAAATATAGAA
    AAAGACCTCACTGATACAAAAAAAGCACAAAATGAATACGAAGAGAAATTGTATCAAGCA
    TATCGATATACCGAAAAAATGAAAACACGTATTGATAGTTTGGCAACGCAAGAGGAAGAA
    TATACTTATTTTTTCAATGGCGTCAAACATATTTTGAAAGCTAAAAATAAAGAATTAAAG
    GGTATTTATGGTGCAGTTGCGGAAATTATTGATGTGCCATCTAAATTAACTCAGGCAATT
    GAAACAGCATTAGGTGCTTCATTACAACATGTCATTGTAGATTCAGAAAAAGATGGACGC
    CAGGCTATTCAATTTTTAAAAGAACGTAATTTAGGTCGTGCGACGTTTTTACCATTAAAT
    GTTATACAGAGTAGAGTGGTAGCGACTGATATTAAATCTATTGCTAAAGAGGCAAACGGA
    TTTATTAGTATCGCTTCGGAAGCAGTTAAAGTAGCACCAGAATATCAAAATATTATCGGG
    AATTTATTAGGTAATACGATTATCGTTGATCATTTAAAGCATGCAAATGAATTGGCACGT
    GCGATTAAATATCGAACTCGTATTGTTACTTTGGAAGGTGATATTGTAAATCCTGGTGGT
    TCTATGACTGGTGGTGGCGCTCGTAAGTCAAAAAGTATTCTGTCTCAAAAAGACGAGTTG
    ACAACAATGAGACACCAATTAGAAGATTACTTGCGTCAAACAGAATCATTTGAACAACAA
    TTTAAAGAGTTGAAGATAAAAAGTGATCAATTAAGTGAACTGTATTTTGAAAAAAGTCAA
    AAGCATAATACACTTAAAGAGCAAGTGCATCATTTTGAAATGGAGCTCGATAGATTAACT
    ACACAAGAAACACAAATAAAAAATGATCATGAAGAATTCGAATTTGAAAAAAATGATGGT
    TATACGAGTGACAAAAGTCGACAAACTTTGAGTGAAAAAGAAACTTATCTAGAAAGTATT
    AAAGCATCTTTAAAACGACTAGAAGATGAAATTGAACGCTACACAAAACTTTCTAAAGAA
    GGTAAGGAAAGCGTTACTAAAACACAACAAACCTTACATCAGAAACAATCTGATCTTGCT
    GTGGTTAAAGAGCGTATTAAAACACAACAACAGACAATAGATCGATTAAATAATCAAAAT
    CAACAAACTAAACATCAATTAAAAGATGTTAAAGAAAAAATTGCATTCTTTAATTCGGAT
    GAAGTGATGGGCGAACAAGCTTTTCAAAATATTAAAGATCAAATTAATGGTCAACAAGAA
    ACGAGAACACGCTTATCAGATGAATTAGATAAATTGAAACAACAACGTATTGAGTTGAAT
    GAACAAATCGATGCGCAAGAAGCTAAACTACAAGTTTGTCACCAAGATATTTTAGCTATC
    GAAAATCACTACCAAGATATTAAAGCTGAACAATCAAAGCTAGATGTATTAATTCATCAT
    GCGATAGATCATTTAAATGATGAATATCAATTGACTGTTGAACGTGCGAAATCTGAATAT
    ACGAGTGATGAATCGATTGACGCATTACGTAAAAAAGTTAAGTTAATGAAGATGTCGATT
    GATGAACTAGGTCCTGTAAACTTAAATGCAATTGAACAATTTGAAGAGTTAAATGAACGT
    TATACATTTTTAAGTGAACAACGTACAGATCTTCGTAAAGCTAAAGAAACATTAGAGCAA
    ATTATAAGTGAAATGGATCAAGAGGTTACTGAAAGATTTAAAGAAACTTTCCATGCTATT
    CAAGGACATTTTACAGCTGTGTTCAAACAATTGTTTGGTGGAGGCGATGCAGAATTGCAA
    TTAACTGAAGCCGATTATTTAACAGCTGGTATTGATATTGTGGTACAACCACCGGGTAAA
    AAGTTGCAACATTTATCGTTACTGAGTGGTGGTGAGCGTGCATTAACTGCTATTGCTTTA
    CTATTTGCAATTTTAAAAGTAAGATCTGCACCTTTTGTTATATTAGATGAGGTTGAAGCT
    GCACTAGATGAAGCAAATGTTATTAGATACGCAAAATATTTAAATGAGTTATCAGACGAA
    ACACAATTCATTGTTATTACACACCGTAAAGGAACAATGGAATTTGCAGATAGGTTATAC
    GGTGTAACAATGCAAGAATCAGGTGTTACTAAACTTGTGAGTGTGAATTTAAATACAATA
    GATGATGTGTTGAAGGAGGAGCAATAA
    60
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    3567

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_RS06455 [old locus tag: NWMN_1144 ]
  • symbol: NWMN_RS06455
  • description: chromosome segregation protein SMC
  • length: 1188
  • theoretical pI: 5.14611
  • theoretical MW: 136748
  • GRAVY: -0.759428

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Cellular processesCellular processesCell divisionchromosome segregation protein SMC (TIGR02168; HMM-score: 1104)
    Genetic information processingDNA metabolismChromosome-associated proteinschromosome segregation protein SMC (TIGR02168; HMM-score: 1104)
    Cellular processesCellular processesCell divisionchromosome segregation protein SMC (TIGR02169; HMM-score: 659.4)
    Genetic information processingDNA metabolismChromosome-associated proteinschromosome segregation protein SMC (TIGR02169; HMM-score: 659.4)
    Genetic information processingDNA metabolismDNA replication, recombination, and repairDNA repair protein RecN (TIGR00634; HMM-score: 55.8)
    helix-rich protein (TIGR04523; HMM-score: 44.7)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 34.9)
    Cell structureCell envelopeBiosynthesis and degradation of surface polysaccharides and lipopolysaccharideslipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 32)
    MetabolismTransport and binding proteinsOtherlipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 32)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 31.2)
    Genetic information processingDNA metabolismDNA replication, recombination, and repairexonuclease SbcC (TIGR00618; HMM-score: 30.3)
    MetabolismTransport and binding proteinsCations and iron carrying compoundscobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 29.8)
    Cellular processesCellular processesPathogenesistype I secretion system ATPase (TIGR03375; HMM-score: 27.6)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype I secretion system ATPase (TIGR03375; HMM-score: 27.6)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsglucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 27.3)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesurea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 26.9)
    MetabolismTransport and binding proteinsCations and iron carrying compoundsnickel import ATP-binding protein NikD (TIGR02770; HMM-score: 24.3)
    SH3 domain protein (TIGR04211; HMM-score: 21.9)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 18.4)
    MetabolismTransport and binding proteinsOtherantigen peptide transporter 2 (TIGR00958; HMM-score: 17.4)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype I secretion system ATPase (TIGR01842; HMM-score: 14)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 13.1)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingheme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 12.6)
    MetabolismTransport and binding proteinsOtherheme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 12.6)
    Genetic information processingDNA metabolismRestriction/modificationDNA sulfur modification protein DndD (TIGR03185; HMM-score: 10.9)
    Hypothetical proteinsConservedTIGR02680 family protein (TIGR02680; HMM-score: 7.5)
  • TheSEED:
  • PFAM:
    P-loop_NTPase (CL0023) SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 208.9)
    no clan definedSMC_hinge; SMC proteins Flexible Hinge Domain (PF06470; HMM-score: 103.1)
    P-loop_NTPase (CL0023) AAA_23; AAA domain (PF13476; HMM-score: 73.6)
    AAA_15; AAA ATPase domain (PF13175; HMM-score: 47.7)
    AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 34.7)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 29.7)
    T3SS-Chaperone (CL0419) FliJ; Flagellar FliJ protein (PF02050; HMM-score: 16.1)
    VPS23_C (CL0596) Mod_r; Modifier of rudimentary (Mod(r)) protein (PF07200; HMM-score: 15.9)
    P-loop_NTPase (CL0023) SbcCD_C; Putative exonuclease SbcCD, C subunit (PF13558; HMM-score: 13.5)
    Reo_sigma (CL0326) Reo_sigmaC; Reovirus sigma C capsid protein (PF04582; HMM-score: 13.2)
    no clan definedDUF1664; Protein of unknown function (DUF1664) (PF07889; HMM-score: 9.5)
    FUSC (CL0307) FUSC; Fusaric acid resistance protein family (PF04632; HMM-score: 8.6)
    no clan definedDUF730; Protein of unknown function (DUF730) (PF05325; HMM-score: 8.2)
    P-loop_NTPase (CL0023) AAA_13; AAA domain (PF13166; HMM-score: 5.4)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.168
    • Ymax_pos: 24
    • Cmax: 0.166
    • Cmax_pos: 24
    • Smax: 0.227
    • Smax_pos: 21
    • Smean: 0.156
    • D: 0.163
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

  • GI: 446184849 NCBI
  • RefSeq: WP_000262704 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MVYLKSIDAIGFKSFADQTNVQFDKGVTAIVGPNGSGKSNITDAIKWVLGEQSAKSLRGSKMEDIIFSGAEHRKAQNYAEVQLRLDNHSKKLSVDENEVIVTRRLYRSGESEYYINNDRARLKDIADLFLDSGLGKEAYSIISQGRVDEILNAKPIDRRQIIEESAGVLKYKKRKAESLNKLDQTEDNLTRVEDILYDLEGRVEPLKEEAAIAKEYKTLSHQMKHSDIVVTVHDIDQYTNDNRQLDQRLNDLQGQQANKEADKQRLSQQIQQYKGKRHQLDNDVESLNYQLVKATEAFEKYTGQLNVLEERKKNQSETNARYEEEQENLMELLENISNEISEAQDTYKSLKSKQKELNAVIRELEEQLYVSDEAHDEKLEEIKNEYYTLMSEQSDVNNDIRFLKHTIEENEAKKSRLDSRLVEVFEQLKDIQGQIKTTKKEYQQTNKELSAVDKEIKNIEKDLTDTKKAQNEYEEKLYQAYRYTEKMKTRIDSLATQEEEYTYFFNGVKHILKAKNKELKGIYGAVAEIIDVPSKLTQAIETALGASLQHVIVDSEKDGRQAIQFLKERNLGRATFLPLNVIQSRVVATDIKSIAKEANGFISIASEAVKVAPEYQNIIGNLLGNTIIVDHLKHANELARAIKYRTRIVTLEGDIVNPGGSMTGGGARKSKSILSQKDELTTMRHQLEDYLRQTESFEQQFKELKIKSDQLSELYFEKSQKHNTLKEQVHHFEMELDRLTTQETQIKNDHEEFEFEKNDGYTSDKSRQTLSEKETYLESIKASLKRLEDEIERYTKLSKEGKESVTKTQQTLHQKQSDLAVVKERIKTQQQTIDRLNNQNQQTKHQLKDVKEKIAFFNSDEVMGEQAFQNIKDQINGQQETRTRLSDELDKLKQQRIELNEQIDAQEAKLQVCHQDILAIENHYQDIKAEQSKLDVLIHHAIDHLNDEYQLTVERAKSEYTSDESIDALRKKVKLMKMSIDELGPVNLNAIEQFEELNERYTFLSEQRTDLRKAKETLEQIISEMDQEVTERFKETFHAIQGHFTAVFKQLFGGGDAELQLTEADYLTAGIDIVVQPPGKKLQHLSLLSGGERALTAIALLFAILKVRSAPFVILDEVEAALDEANVIRYAKYLNELSDETQFIVITHRKGTMEFADRLYGVTMQESGVTKLVSVNLNTIDDVLKEEQ

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • NWMN_RS06455 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]