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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS14055 [old locus tag: NWMN_2445 ]
  • pan locus tag?: SAUPAN006206000
  • symbol: NWMN_RS14055
  • pan gene symbol?: mvaA
  • synonym:
  • product: hydroxymethylglutaryl-CoA reductase, degradative

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: NWMN_RS14055 [old locus tag: NWMN_2445 ]
  • symbol: NWMN_RS14055
  • product: hydroxymethylglutaryl-CoA reductase, degradative
  • replicon: chromosome
  • strand: -
  • coordinates: 2687440..2688717
  • length: 1278
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_009641 (2687440..2688717) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGCAAAATTTAGATAAGAATTTTCGACATTTATCTCGTAAAGAAAAGTTACAACAATTG
    GTTGATAAGCAATGGTTATCAGAAGAACAATTCGACATTTTACTGAATCATCCATTAATC
    GATGAAGAAGTAGCCAATAGTTTAATTGAAAATGTCATCGCGCAAGGTGCATTACCCGTT
    GGATTATTACCGAATATCATTGTGGACGATAAGGCATATGTTGTACCTATGATGGTGGAA
    GAGCCTTCAGTTGTCGCTGCAGCTAGTTATGGTGCAAAGCTAGTGAATCAGACTGGCGGA
    TTTAAAACGGTATCTTCTGAACGTATTATGATAGGTCAAATCGTCTTTGATGGCGTTGAC
    GATACTGAAAAATTATCAGCAGACATTAAAGCTTTAGAAAAGCAAATTCATAAAATTGCG
    GATGAGGCATATCCTTCTATTAAAGCGCGTGGTGGTGGTTACCAACGTATAGCGATTGAT
    ACATTTCCTGAGCAACAGTTACTATCTTTAAAAGTATTTGTTGATACGAAAGATGCTATG
    GGCGCTAATATGCTTAATACGATTTTAGAGGCCATAACTGCATTTTTAAAAAATGAATTT
    CCGCAAAGCGACATTTTAATGAGTATTTTATCCAATCATGCAACAGCGTCCGTTGTTAAA
    GTTCAAGGCGAAATTGATGTTAAAGATTTAGCAAGGGGCGAGAGAACTGGAGAAGAGGTT
    GCCAAACGAATGGAACGTGCTTCTGTATTGGCCCAAGTAGATATTCATCGTGCAGCAACA
    CATAATAAAGGTGTTATGAATGGCATACATGCTGTTGTTTTAGCAACAGGAAATGATACG
    CGTGGTGCAGAAGCAAGTGCGCATGCATACGCGAGTCGTGACGGACAGTATCGTGGTATT
    GCTACATGGCGTTACGATCAAGATCGTCAACGATTGATTGGTACAATTGAAGTGCCTATG
    ACATTGGCAATCGTTGGCGGTGGTACAAAAGTATTACCAATTGCTAAAGCTTCATTAGAG
    CTACTAAATGTAGAGTCAGCACAAGAATTAGGTCATGTAGTTGCTGCCGTTGGTTTAGCG
    CAAAACTTTGCAGCATGTCGCGCGCTTGTGTCAGAAGGTATTCAACAAGGTCATATGAGT
    TTACAATATAAATCATTAGCTATCGTTGTAGGGGCAAAAGGTGATGAAATTGCTAAAGTA
    GCTGAAGCTTTGAAAAAAGAACCCCGTGCAAATACACAAGCAGCGGAACATATTTTACAA
    GAAATTAGACAACAATAG
    60
    120
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    720
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    840
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    1020
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    1140
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    1260
    1278

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: NWMN_RS14055 [old locus tag: NWMN_2445 ]
  • symbol: NWMN_RS14055
  • description: hydroxymethylglutaryl-CoA reductase, degradative
  • length: 425
  • theoretical pI: 5.98668
  • theoretical MW: 46236.6
  • GRAVY: -0.109647

Function[edit source | edit]

  • reaction:
    EC 1.1.1.88?  ExPASy
    Hydroxymethylglutaryl-CoA reductase(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH
  • TIGRFAM:
    MetabolismEnergy metabolismOtherhydroxymethylglutaryl-CoA reductase, degradative (TIGR00532; EC 1.1.1.88; HMM-score: 335)
    MetabolismCentral intermediary metabolismOtherhydroxymethylglutaryl-CoA reductase (NADPH) (TIGR00533; EC 1.1.1.34; HMM-score: 63.6)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acids3-hydroxy-3-methylglutaryl-coenzyme A reductase (TIGR00920; HMM-score: 53.7)
  • TheSEED:
  • PFAM:
    no clan definedHMG-CoA_red; Hydroxymethylglutaryl-coenzyme A reductase (PF00368; HMM-score: 341.2)
    DUF2493; Protein of unknown function (DUF2493) (PF10686; HMM-score: 14.5)
    UPF0180; Uncharacterised protein family (UPF0180) (PF03698; HMM-score: 14.2)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.149
    • Ymax_pos: 11
    • Cmax: 0.109
    • Cmax_pos: 57
    • Smax: 0.339
    • Smax_pos: 2
    • Smean: 0.225
    • D: 0.178
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

  • GI: 447103067 NCBI
  • RefSeq: WP_001180323 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MQNLDKNFRHLSRKEKLQQLVDKQWLSEEQFDILLNHPLIDEEVANSLIENVIAQGALPVGLLPNIIVDDKAYVVPMMVEEPSVVAAASYGAKLVNQTGGFKTVSSERIMIGQIVFDGVDDTEKLSADIKALEKQIHKIADEAYPSIKARGGGYQRIAIDTFPEQQLLSLKVFVDTKDAMGANMLNTILEAITAFLKNEFPQSDILMSILSNHATASVVKVQGEIDVKDLARGERTGEEVAKRMERASVLAQVDIHRAATHNKGVMNGIHAVVLATGNDTRGAEASAHAYASRDGQYRGIATWRYDQDRQRLIGTIEVPMTLAIVGGGTKVLPIAKASLELLNVESAQELGHVVAAVGLAQNFAACRALVSEGIQQGHMSLQYKSLAIVVGAKGDEIAKVAEALKKEPRANTQAAEHILQEIRQQ

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • NWMN_RS14055 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]