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NCBI: 26-AUG-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus N315
  • locus tag: SA0993 [new locus tag: SA_RS05630 ]
  • pan locus tag?: SAUPAN003385000
  • symbol: uvrC
  • pan gene symbol?: uvrC
  • synonym:
  • product: excinuclease ABC subunit C

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SA0993 [new locus tag: SA_RS05630 ]
  • symbol: uvrC
  • product: excinuclease ABC subunit C
  • replicon: chromosome
  • strand: +
  • coordinates: 1125255..1127036
  • length: 1782
  • essential: yes DEG other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    TTGGAAGACTATAAGCAACGAATTAAAAATAAATTAAATGTCGTACCTATGGAACCAGGC
    TGCTATTTAATGAAAGATCGTAATGATCAAGTGATATATGTTGGCAAAGCTAAAAAGCTA
    AGAAATCGATTGAGATCATATTTTACGGGTGCTCATGATGCTAAAACAACGAGACTGGTT
    GGTGAAATACGTCGTTTTGAGTTTATTGTCACGTCAAGTGAAACAGAGTCACTTTTACTG
    GAATTGAATCTGATAAAACAATATCAACCAAGATATAATATATTATTAAAGGATGATAAA
    AGTTATCCATTTATTAAAATTACGAAGGAGAAATATCCTAGACTACTAGTGACGAGAACT
    GTAAAACAAGGTACTGGCAAATATTTCGGACCGTATCCGAATGCATATTCTGCTCAAGAA
    ACTAAAAAGTTATTAGACAGAATATATCCATATCGCAAATGTGATAAGATGCCAGATAAA
    TTATGTCTTTATTACCATATTGGACAATGTTTAGGACCATGTGTATATGACGTTGATTTG
    AGTAAATACGCACAAATGACGAAGGAAATTACTGATTTTCTGAATGGGGAAGACAAAACA
    ATTTTAAAAAGTTTAGAAGAGCGAATGTTAACTGCAAGTGAATCACTTGATTTTGAACGG
    GCTAAAGAATATAGAGATTTAATTCAACATATTCAAAATCTGACAAACAAACAAAAAATT
    ATGTCATCAGATAAAACGATTCGTGATGTCTTTGGTTATTGTGTTGATAAAGGATGGATG
    TGTATCCAAGTTTTCTTTATACGACAAGGTAATATGATAAAGCGAGATACAACGATGATT
    CCATTACAGCAAACAGAAGAAGAAGAATTTTATACATTTATTGGACAATTTTATAGCTTA
    AACCAACATATTTTACCTAAGGAAGTTCATGTACCACGTAATTTGGATAAAGAAATGATT
    CAATCTGTTGTGGACACTAAAATCGTTCAACCCGCGCGAGGTCCCAAAAAAGATATGGTT
    GACCTAGCTGCACATAACGCTAAAGTATCCTTAAATAATAAATTTGAATTAATATCACGT
    GATGAGTCAAGAACGATTAAAGCTATTGAAGAACTTGGAACACAAATGGGAATTCAAACA
    CCAATTAGAATTGAAGCATTCGATAATTCTAATATTCAAGGTGTGGATCCAGTGTCAGCA
    ATGGTTACATTTGTCGACGGTAAACCAGATAAGAAAAATTATAGAAAGTATAAAATCAAA
    ACGGTTAAAGGTCCAGATGATTACAAATCAATGAGAGAAGTAGTAAGACGACGATATTCT
    CGCGTTTTAAACGAAGGATTACCATTACCTGATTTAATAATAGTCGATGGTGGTAAAGGA
    CATATGAACGGGGTTATTGATGTGCTACAAAACGAATTAGGTCTTGATATCCCTGTTGCA
    GGTTTGCAGAAAAATGATAAACACCAAACATCTGAATTATTATATGGCGCTAGTGCAGAA
    ATTGTACCACTGAAGAAAAATAGCCAGGCATTTTATTTGTTGCATCGTATCCAAGATGAG
    GTTCACAGATTCGCAATCACATTTCATAGACAAACACGTCAAAAGACAGGCTTGAAATCA
    ATACTTGATGATATAGATGGTATCGGTAACAAACGTAAAACATTATTATTGCGTTCATTC
    GGTTCAATCAAGAAAATGAAGGAAGCTACACTTGAAGATTTTAAAAATATAGGTATTCCT
    GAAAACGTCGCAAAGAACCTACATGAACAATTGCATAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1782

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SA0993 [new locus tag: SA_RS05630 ]
  • symbol: UvrC
  • description: excinuclease ABC subunit C
  • length: 593
  • theoretical pI: 9.74886
  • theoretical MW: 68687
  • GRAVY: -0.571669

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Genetic information processingDNA metabolismDNA replication, recombination, and repairexcinuclease ABC subunit C (TIGR00194; EC 3.1.25.-; HMM-score: 660)
    group I intron endonuclease (TIGR01453; HMM-score: 13.6)
  • TheSEED:  
    DNA MetabolismDNA repairDNA repair, UvrABC system Excinuclease ABC subunit C 
  • PFAM:
    Endonuclease (CL0189) UvrC_HhH_N; UvrC Helix-hairpin-helix N-terminal (PF08459; HMM-score: 179.3)
    GIY-YIG (CL0418) GIY-YIG; GIY-YIG catalytic domain (PF01541; HMM-score: 44.9)
    no clan definedUVR; UvrB/uvrC motif (PF02151; HMM-score: 40)
    HHH (CL0198) HHH_2; Helix-hairpin-helix motif (PF12826; HMM-score: 18.4)
    no clan definedDUF3936; Protein of unknown function (DUF3936) (PF13072; HMM-score: 12.1)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.115
    • Ymax_pos: 11
    • Cmax: 0.104
    • Cmax_pos: 25
    • Smax: 0.208
    • Smax_pos: 1
    • Smean: 0.112
    • D: 0.114
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MEDYKQRIKNKLNVVPMEPGCYLMKDRNDQVIYVGKAKKLRNRLRSYFTGAHDAKTTRLVGEIRRFEFIVTSSETESLLLELNLIKQYQPRYNILLKDDKSYPFIKITKEKYPRLLVTRTVKQGTGKYFGPYPNAYSAQETKKLLDRIYPYRKCDKMPDKLCLYYHIGQCLGPCVYDVDLSKYAQMTKEITDFLNGEDKTILKSLEERMLTASESLDFERAKEYRDLIQHIQNLTNKQKIMSSDKTIRDVFGYCVDKGWMCIQVFFIRQGNMIKRDTTMIPLQQTEEEEFYTFIGQFYSLNQHILPKEVHVPRNLDKEMIQSVVDTKIVQPARGPKKDMVDLAAHNAKVSLNNKFELISRDESRTIKAIEELGTQMGIQTPIRIEAFDNSNIQGVDPVSAMVTFVDGKPDKKNYRKYKIKTVKGPDDYKSMREVVRRRYSRVLNEGLPLPDLIIVDGGKGHMNGVIDVLQNELGLDIPVAGLQKNDKHQTSELLYGASAEIVPLKKNSQAFYLLHRIQDEVHRFAITFHRQTRQKTGLKSILDDIDGIGNKRKTLLLRSFGSIKKMKEATLEDFKNIGIPENVAKNLHEQLHK

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]