NCBI: 26-AUG-2013

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA1598 [new locus tag: SA_RS09000 ]
• pan locus tag^?: SAUPAN004476000
• symbol: SA1598
• pan gene symbol^?: spdA
• synonym:
• product: hypothetical protein

⊟Gene

⊟General

• type: CDS
• locus tag: SA1598 [new locus tag: SA_RS09000 ]
• symbol: SA1598
• product: hypothetical protein
• replicon: chromosome
• strand: +
• coordinates: 1835822..1836457
• length: 636
• essential: no DEG other strains

⊟Accession numbers

• Gene ID: 1124444 NCBI
• RefSeq: NP_374887 NCBI
• MicrobesOnline: 103913 MicrobesOnline

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

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  ATGCAAAAATTCAAAGACTTTTTTTACGATGATTTATCGGTTACACGAGGAAATTATTTT
  TTAACTTTAATGGCAGCATTTTTTATTACTATCATTTTATTTATCGGCATAGTTGTCAGT
  GAAGTACATTTACTTTATAGCATGCTAATTGTATTAGTAGGTTTAATTCTATTGAGGCTA
  TTCAAAATCAATTTATTCTCTTTTAAAAAATTAACATTGTCTCAAGTTATTTATATTATA
  GGCGGTGCACTATTAATTTATGGGTTAGATAATCTTTATTTATATTTTCATGACGTACCG
  GCAAATGAACTACAATTAGAGCAAGAAATACGAAATACACCATTCTATATTTCTATTTTC
  ACTGTTACCATCATCCCCGCTATTGTGGAAGAAATTGTTTTTCGCGGTATGATAATAAGG
  GTTATATTCAGAAAACACTTATTTTTAGGGTTACTTGTGTCTAGTTTAGTTTTTGCATCA
  TTACACGAATCTGACACTTGGATTGGTTATTTACCTTACTTATATTCTGGTTTGATTTTT
  GGTCTAATTTATATAAAAACAAAACGATTAGAAGTGGTAATATTCATGCACTTCTTAAAT
  AACTTGTTAGCTCTGCTCTTTATAATATGGGGATAA
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⊟Protein

⊟General

• locus tag: SA1598 [new locus tag: SA_RS09000 ]
• symbol: SA1598
• description: hypothetical protein
• length: 211
• theoretical pI: 8.67223
• theoretical MW: 24540.4
• GRAVY: 1.00995

⊟Function

• reaction:
• TIGRFAM:
  exosortase E/protease, VPEID-CTERM system (TIGR04162; EC 3.4.22.-; HMM-score: 30.4)
  Cell structureCell envelopeBiosynthesis and degradation of surface polysaccharides and lipopolysaccharidesCAAX prenyl protease-related protein (TIGR03008; HMM-score: 23.7)
• TheSEED:  
  CAAX amino terminal protease family protein 
• PFAM:
  Peptidase_U (CL0472) Abi; CAAX protease self-immunity (PF02517; HMM-score: 56)

⊟Structure, modifications & interactions

• domains:
• modifications:
• cofactors:
• effectors:
• protein partners:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 10
  • Cellwall Score: 0
  • Extracellular Score: 0
  • Internal Helices: 7
• LocateP: Multi-transmembrane
  • Prediction by SwissProt Classification: Membrane
  • Pathway Prediction: Sec-(SPI)
  • Intracellular Possibility: 0.17
  • Signal Peptide Possibility: -0.5
  • N-terminally Anchored Score: 1
  • Predicted Cleavage Site: No CleavageSite
• SignalP: no predicted signal peptide
  • Ymax: 0.095
  • Ymax_pos: 70
  • Cmax: 0.174
  • Cmax_pos: 41
  • Smax: 0.123
  • Smax_pos: 66
  • Smean: 0.045
  • D: 0.075
• predicted transmembrane helices (TMHMM): 7

⊟Accession numbers

• GI: 15927354 NCBI
• RefSeq: NP_374887 NCBI
• UniProt: A0A0H3JMG7 UniProt

⊟Protein sequence

• MQKFKDFFYDDLSVTRGNYFLTLMAAFFITIILFIGIVVSEVHLLYSMLIVLVGLILLRLFKINLFSFKKLTLSQVIYIIGGALLIYGLDNLYLYFHDVPANELQLEQEIRNTPFYISIFTVTIIPAIVEEIVFRGMIIRVIFRKHLFLGLLVSSLVFASLHESDTWIGYLPYLYSGLIFGLIYIKTKRLEVVIFMHFLNNLLALLFIIWG

⊟Experimental data

• experimentally validated: no data available

⊟Expression & Regulation

⊟Operon

• SA1598 no polycistronic organisation predicted

⊟Regulation

• sigma factor:
• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟Relevant publications

Matthew B Frankel, Brandon M Wojcik, Andrea C DeDent, Dominique M Missiakas, Olaf Schneewind
ABI domain-containing proteins contribute to surface protein display and cell division in Staphylococcus aureus.
Mol. Microbiol.: 2010, 78(1);238-52
[PubMed:20923422] [WorldCat.org] [DOI] (I p)