NCBI: 10-JUN-2013
Contents
⊟Summary[edit source | edit]
- organism: Staphylococcus aureus COL
- locus tag: SACOL1709 [new locus tag: SACOL_RS08730 ]
- pan locus tag?: SAUPAN004274000
- symbol: folC
- pan gene symbol?: folC
- synonym:
- product: folylpolyglutamate synthase/dihydrofolate synthase
⊟Genome View[edit source | edit]
⊟Gene[edit source | edit]
⊟General[edit source | edit]
- type: CDS
- locus tag: SACOL1709 [new locus tag: SACOL_RS08730 ]
- symbol: folC
- product: folylpolyglutamate synthase/dihydrofolate synthase
- replicon: chromosome
- strand: -
- coordinates: 1738352..1739623
- length: 1272
- essential: unknown other strains
⊟Accession numbers[edit source | edit]
- Gene ID: 3238701 NCBI
- RefSeq: YP_186548 NCBI
- MicrobesOnline: 913157 MicrobesOnline
⊟Phenotype[edit source | edit]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit source | edit]
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1261ATGAATTACCTAGAGAGCTTGTATTGGATACACGAAAGAACTAAATTTGGCATCAAACCA
GGTGTTAAACGTATGGAATGGATGCTAGCACAATTTAATAATCCTCAAAATAACATTAAG
GGTATTCATGTAGGTGGCACAAATGGTAAAGGCTCTACAGTTGCTTACCTTAGAACAGCT
TTAGTTGAAAATGGTTATGAAGTAGGTACATTTACGTCGCCGTTTATTGAAACATTTAAT
GAACGAATTAGTCTAAATGGTGTGCCAATATCAAATGACGCTATTGTAGAATTAGTATCA
CGTATTAAACCAGTAAGTGAAATGATGGAACGTGAAACAGATTTAGGTGTTGCAACTGAA
TTCGAAATAATCACAGCGATGATGTTTTTATATTTTGGTGAAATACATCCTGTTGATTTT
GTCATTGTTGAGGCTGGATTGGGTATAAAGAACGATTCGACAAATGTCTTTACACCGGTT
TTATCAATCTTAACTAGTATCGGTCTAGACCATACAGATATTTTAGGTGGTACTTATCTA
GATATTGCTAGGGATAAAGGCGCGATTATAAAGCCTAACGTTCCAGTGATATATGCTGTT
AAAAATGAAGATGCATTAAAATATGTTCGTGAACGCGCAATTGAACAACATGCAAAGCCA
ATTGAATTAGATAGAGAAATTGTTGTTGTATCGCAAAATGATGAATTTACTTACCGTTAT
AAAGATTATGAATTAGAAACAATCATTTTAAGCATGTTAGGTGAACATCAGAAACAAAAT
GCTGCATTAGCCATAACAGCTCTTATTGAATTAAATGAACAAGGATTAATTGAATTAGAT
TTCAATAAGATGATAGACGGTATTGAATCAGTTCGTTGGACTGGACGTATTGAGCAGGTG
CATGACAAACCTTTAATCATTTTGGATGGCGCACATAATTCAGAGAGTATAGATGCTCTA
ATTGATACAATTAAACAGTACCATGATAAAGAAAAAGTAGATATTTTGTTCTCAGCAATA
AACGGAAAACCGATTAACGAGATGGTCAAACATTTAAGTTTAATTGCGCATACGTTTTAT
GCAACTGAATTTGATTTTCCGAAAGCGTTACGCAAAGAAGAAATTGTAGGTAGTATTGAA
AATGATGAAATACAATTAGTAGATGACTACGTTGAATTTATAAAAAATTATCAAGGTGAT
ACATTAGTAATTACCGGTAGTCTGTATTTCATAAGTGAAGTTAAATCAAAATTAGACTTT
GAAGCATTATAA60
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⊟Protein[edit source | edit]
⊟General[edit source | edit]
- locus tag: SACOL1709 [new locus tag: SACOL_RS08730 ]
- symbol: FolC
- description: folylpolyglutamate synthase/dihydrofolate synthase
- length: 423
- theoretical pI: 4.55771
- theoretical MW: 47856.3
- GRAVY: -0.0959811
⊟Function[edit source | edit]
- reaction: EC 6.3.2.17? ExPASyTetrahydrofolate synthaseATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1)
- TIGRFAM: Biosynthesis of cofactors, prosthetic groups, and carriersFolic acidbifunctional protein FolC (TIGR01499; EC 6.3.2.-; HMM-score: 376.6)Cell envelopeBiosynthesis and degradation of murein sacculus and peptidoglycanUDP-N-acetylmuramyl-tripeptide synthetase (TIGR01085; HMM-score: 55)Cell envelopeBiosynthesis and degradation of murein sacculus and peptidoglycanUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (TIGR01143; EC 6.3.2.10; HMM-score: 41.2)Cell envelopeBiosynthesis and degradation of murein sacculus and peptidoglycanUDP-N-acetylmuramate--L-alanine ligase (TIGR01082; EC 6.3.2.8; HMM-score: 35.7)Cell envelopeOtherpoly-gamma-glutamate synthase PgsB (TIGR04012; EC 6.3.2.-; HMM-score: 19.7)Cell envelopeBiosynthesis and degradation of murein sacculus and peptidoglycanUDP-N-acetylmuramoylalanine--D-glutamate ligase (TIGR01087; EC 6.3.2.9; HMM-score: 15.1)
- TheSEED: Cofactors, Vitamins, Prosthetic Groups, PigmentsFolate and pterinesFolate Biosynthesis Dihydrofolate synthase (EC 6.3.2.12)
- PFAM: no clan definedMur_ligase_M; Mur ligase middle domain (PF08245; HMM-score: 42.8)Mur_ligase_C; Mur ligase family, glutamate ligase domain (PF02875; HMM-score: 27.5)ACT (CL0070) ALS_ss_C; Small subunit of acetolactate synthase (PF10369; HMM-score: 13.8)P-loop_NTPase (CL0023) AAA_14; AAA domain (PF13173; HMM-score: 13.5)
⊟Structure, modifications & interactions[edit source | edit]
- domains:
- modifications:
- cofactors:
- effectors:
- protein partners:
⊟Localization[edit source | edit]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular Possibility: 1
- Signal Peptide Possibility: -1
- N-terminally Anchored Score: -1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- Ymax: 0.129
- Ymax_pos: 42
- Cmax: 0.115
- Cmax_pos: 25
- Smax: 0.194
- Smax_pos: 37
- Smean: 0.135
- D: 0.132
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit source | edit]
⊟Protein sequence[edit source | edit]
- MNYLESLYWIHERTKFGIKPGVKRMEWMLAQFNNPQNNIKGIHVGGTNGKGSTVAYLRTALVENGYEVGTFTSPFIETFNERISLNGVPISNDAIVELVSRIKPVSEMMERETDLGVATEFEIITAMMFLYFGEIHPVDFVIVEAGLGIKNDSTNVFTPVLSILTSIGLDHTDILGGTYLDIARDKGAIIKPNVPVIYAVKNEDALKYVRERAIEQHAKPIELDREIVVVSQNDEFTYRYKDYELETIILSMLGEHQKQNAALAITALIELNEQGLIELDFNKMIDGIESVRWTGRIEQVHDKPLIILDGAHNSESIDALIDTIKQYHDKEKVDILFSAINGKPINEMVKHLSLIAHTFYATEFDFPKALRKEEIVGSIENDEIQLVDDYVEFIKNYQGDTLVITGSLYFISEVKSKLDFEAL
⊟Experimental data[edit source | edit]
- experimentally validated: PeptideAtlasquantitative data / protein copy number per cell: 15 [4]
⊟Expression & Regulation[edit source | edit]
⊟Operon[edit source | edit]
⊟Regulation[edit source | edit]
- sigma factor:
- regulator:
⊟Transcription pattern[edit source | edit]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit source | edit]
- Aureolib: no data available
⊟Protein stability[edit source | edit]
- half-life: no data available
⊟Biological Material[edit source | edit]
⊟Mutants[edit source | edit]
⊟Expression vector[edit source | edit]
⊟lacZ fusion[edit source | edit]
⊟GFP fusion[edit source | edit]
⊟two-hybrid system[edit source | edit]
⊟FLAG-tag construct[edit source | edit]
⊟Antibody[edit source | edit]
⊟Other Information[edit source | edit]
You are kindly invited to share additional interesting facts.
⊟Literature[edit source | edit]
⊟References[edit source | edit]
- ↑
Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
PLoS ONE: 2009, 4(12);e8176
[PubMed:19997597] [WorldCat.org] [DOI] (I e) - ↑
Kristina Hempel, Florian-Alexander Herbst, Martin Moche, Michael Hecker, Dörte Becher
Quantitative proteomic view on secreted, cell surface-associated, and cytoplasmic proteins of the methicillin-resistant human pathogen Staphylococcus aureus under iron-limited conditions.
J. Proteome Res.: 2011, 10(4);1657-66
[PubMed:21323324] [WorldCat.org] [DOI] (I p) - ↑
Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
The Staphylococcus aureus proteome.
Int. J. Med. Microbiol.: 2014, 304(2);110-20
[PubMed:24439828] [WorldCat.org] [DOI] (I p) - ↑
Daniela Zühlke, Kirsten Dörries, Jörg Bernhardt, Sandra Maaß, Jan Muntel, Volkmar Liebscher, Jan Pané-Farré, Katharina Riedel, Michael Lalk, Uwe Völker, Susanne Engelmann, Dörte Becher, Stephan Fuchs, Michael Hecker
Costs of life - Dynamics of the protein inventory of Staphylococcus aureus during anaerobiosis.
Sci Rep: 2016, 6;28172
[PubMed:27344979] [WorldCat.org] [DOI] (I e)
⊟Relevant publications[edit source | edit]