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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS06265 [old locus tag: SACOL1223 ]
  • pan locus tag?: SAUPAN003493000
  • symbol: SACOL_RS06265
  • pan gene symbol?: coaBC
  • synonym:
  • product: phosphopantothenoylcysteine decarboxylase

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL_RS06265 [old locus tag: SACOL1223 ]
  • symbol: SACOL_RS06265
  • product: phosphopantothenoylcysteine decarboxylase
  • replicon: chromosome
  • strand: +
  • coordinates: 1231674..1232873
  • length: 1200
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_002951 (1231674..1232873) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
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    1021
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    1141
    ATGAAGAAAATATTATTAGCCGTTACAGGTGGCATTGCGGCATATAAAGCAATTGATTTG
    ACAAGTAAGTTAACACAATCTGGGTATGAAGTTCGCGTTATGTTAACGAATCACGCACAA
    AAATTTGTGACACCATTAGCATTTCAAGCAATAAGTCGAAATGCTGTTTATACAGATACT
    TTTATAGAAGAAAATCCTTCAGAAATACAGCATATTGCATTAGGTGATTGGGCAGATGCA
    ATCATTGTTGCACCTGCAACGGCAAATACAATTGCAAAATTGAGTGTAGGTATTGCTGAT
    GATTTGGTGACATCAACGTTGCTAGCAACAGAGACACCGAAATTTATTGCGCCTGCTATG
    AATGTGCATATGTATGAAAATAAACGTACGCAGCAAAATATTAATATTTTAAAAGAAGAT
    GGGTATCATTTTATCGAACCAGGAAGCGGATTTCTAGCATGTGGTTATGTTGCTAAAGGA
    CGTATGGAAGAACCGCTTCAAATCGTTTCTGTAATTGATGCTCATTTTCAAAATAGTAAT
    CGTTTAGCTAATAGTTCATTTCAAGATAAACGCGCATTGGTTACAGCAGGACCAACTATT
    GAAGTTATCGATCCAGTCAGATTTGTATCCAATCGTTCTTCTGGAAAAATGGGCTATGCA
    ATAGCTGAAGCATTGCGAAATCGAGGAGCTATCGTGACGTTAGTTGCTGGTCCTACAACA
    CTAGAGGATCCAAAAGATATTGAAGTTATTCATGTTCAAAGTGCTGAAGAAATGTTTGAA
    CAAGTGACAAGCCGATTTGACGAACAAGATATTGTTGTAAAAGCAGCAGCCGTATCTGAC
    TATACACCGATTGATGTATTAGAACATAAGATGAAAAAGCAGGATGGTGATTTGTCAGTA
    TCTTTTAAACGTACTAAAGACATTCTTAAATATTTAGGTGAACATAAAACATCACAGTAT
    TTAATAGGCTTTGCAGCAGAGACTGAAGATATTGAAAATTATGCACAACAAAAATTACGC
    AAGAAAAATGCAGATGTGATTATTTCAAATAATGTTGGGGATATGTCTATCGGATTTAGT
    TCTGATGATAATGAATTGACAATGCATTTTAAAAATAATGAAAAAGTAAATATCAAGAAA
    GGAAAAAAAGTAGTATTAGCTGCACAAATTTTAGATGAACTAGAAACTAGGTGGCAATAA
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    1200

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL_RS06265 [old locus tag: SACOL1223 ]
  • symbol: SACOL_RS06265
  • description: phosphopantothenoylcysteine decarboxylase
  • length: 399
  • theoretical pI: 5.87138
  • theoretical MW: 44154
  • GRAVY: -0.210526

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersPantothenate and coenzyme Aphosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase (TIGR00521; EC 4.1.1.36,6.3.2.5; HMM-score: 476.8)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersPantothenate and coenzyme Aphosphopantothenoylcysteine decarboxylase (TIGR02113; EC 4.1.1.36; HMM-score: 208.5)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersPantothenate and coenzyme Aphosphopantothenate--cysteine ligase (TIGR02114; EC 6.3.2.5; HMM-score: 70.9)
    MetabolismEnergy metabolismElectron transportarchaeoflavoprotein AfpA (TIGR02699; HMM-score: 32.3)
    Unknown functionGeneralarchaeoflavoprotein, MJ0208 family (TIGR02700; HMM-score: 31.4)
    Unknown functionEnzymes of unknown specificitypolyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases (TIGR00421; EC 4.1.1.-; HMM-score: 27.7)
    Cellular processesCellular processesSporulation and germinationdipicolinic acid synthetase, B subunit (TIGR02852; HMM-score: 16.5)
  • TheSEED:
  • PFAM:
    NADP_Rossmann (CL0063) DFP; DNA / pantothenate metabolism flavoprotein (PF04127; HMM-score: 232.6)
    no clan definedFlavoprotein; Flavoprotein (PF02441; HMM-score: 161.6)
    NADP_Rossmann (CL0063) YjeF_N; YjeF-related protein N-terminus (PF03853; HMM-score: 17.5)
    adh_short_C2; Enoyl-(Acyl carrier protein) reductase (PF13561; HMM-score: 16.1)
    SPFH (CL0433) Band_7; SPFH domain / Band 7 family (PF01145; HMM-score: 13.9)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.207
    • Ymax_pos: 14
    • Cmax: 0.121
    • Cmax_pos: 51
    • Smax: 0.55
    • Smax_pos: 12
    • Smean: 0.39
    • D: 0.279
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

  • GI: 446644818 NCBI
  • RefSeq: WP_000722164 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MKKILLAVTGGIAAYKAIDLTSKLTQSGYEVRVMLTNHAQKFVTPLAFQAISRNAVYTDTFIEENPSEIQHIALGDWADAIIVAPATANTIAKLSVGIADDLVTSTLLATETPKFIAPAMNVHMYENKRTQQNINILKEDGYHFIEPGSGFLACGYVAKGRMEEPLQIVSVIDAHFQNSNRLANSSFQDKRALVTAGPTIEVIDPVRFVSNRSSGKMGYAIAEALRNRGAIVTLVAGPTTLEDPKDIEVIHVQSAEEMFEQVTSRFDEQDIVVKAAAVSDYTPIDVLEHKMKKQDGDLSVSFKRTKDILKYLGEHKTSQYLIGFAAETEDIENYAQQKLRKKNADVIISNNVGDMSIGFSSDDNELTMHFKNNEKVNIKKGKKVVLAAQILDELETRWQ

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SACOL_RS06265 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]