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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS07035 [old locus tag: SACOL1382 ]
  • pan locus tag?: SAUPAN003722000
  • symbol: SACOL_RS07035
  • pan gene symbol?: sbcC
  • synonym:
  • product: nuclease SbcCD subunit C

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL_RS07035 [old locus tag: SACOL1382 ]
  • symbol: SACOL_RS07035
  • product: nuclease SbcCD subunit C
  • replicon: chromosome
  • strand: +
  • coordinates: 1384730..1387759
  • length: 3030
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_002951 (1384730..1387759) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
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    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    ATGAAACCATTACATTTAAAGTTGAATAATTTCGGCCCCTTTTTAAAAGAAGAAATTGAT
    TTTTCTAAAATTGATAATAATGAATTGTTTTTAATAAGTGGTAAGACTGGATCGGGTAAA
    ACAATGATTTTTGATGCAATGACTTATGCCTTGTTTGGTAAAGCATCAACTGAACAAAGA
    GAAGAAAATGATTTGAGAAGTCATTTCGCTGATGGTAAACAGCCGATGTCAGTAACATTT
    GAATTTCAATTAAATCATCGAATTTATAAAGTGCATAGACAAGGCCCTTATATCAAAGAA
    GGTAATACAACAAAAACGAACGCTAAATTTGATGTATTTGAGATGGTGGATGGCAAGTAT
    GAAATTAGAGAAAGTAAAGTAATTTCAGGTACCCAATTCATTATTGAATTATTAGGAGTA
    AATGCAGATCAATTCCGACAATTGTTTATTTTGCCTCAAGGTGAATTCAAACGCTTTTTA
    ATATCAAACAGTCGTGAAAAGCAAGGGATATTAAGAACACTGTTTGACAGTGAAAAATTT
    GAAGCTATACGAGAAATATTAAAAGAAGAAGTAAAAAAAGAAAAAGCTCAAATCGAGAAT
    AGATATCAACAAATTGACCTTTTATGGCAAGAAATTGAATCATTTGATGATGACAATATA
    AAAGGCTTATTAGAGGTTGCCACTCAACAGATAGACAAATTGATTGAAAATATACCACTT
    TTACAAGCTAGGTCGAAAGAAATACTAGCATCTGTAAATGAAAGTAAAGAAACTGCTATT
    AAAGAATTTGAAATAATAGAAAAGAAAACATTAGAAAATAATATATTAAAAGATAATATT
    AATCAACTCAACAAAAATAAAATTGATTTCGTTCAATTGAAAGAACAACAACCTGAAATA
    GAGGGAATTGAAGCTAAGTTAAAGTTGTTACAAGATATTACAAACCTATTGAATTATATT
    GAAAATAGAGAAAAAATTGAAACTAAAATTGCTAATAGCAAAAAAGATATTTCTAAAACC
    AATAATAAAATATTGAATCTTGATTGTGATAAGCGAAACATAGACAAAGAGAAAAAAATG
    TTAGAAGAAAATGGAGATTTAATTGAAAGTAAAATCTCTTTTATTGATAAAACTAGAGTA
    TTATTTAACGATATTAATAAGTATCAACAAAGTTATCTCAATATTGAACGCTTGAGAACT
    GAGGGTGAACAATTAGGTGATGAATTAAATGATCTAATTAAAGGTTTAGAAACGGTCGAA
    GATTCAATAGGTAATAACCAAAGTGATTACGAGAAAATTATCGAACTAAATAATACGATA
    ACGAACATAAATAATGAAATTAATATAATTAAAGAAAATGAAAAAGCTAAAGCTGAATTA
    GATAAACTATTAGGTAGTAAGCAAGAGTTAGAGAATCAAATTAATGAAGAAACATCTATA
    TTGAAGAATCTCGAAATAAAATTAGATCGCTACGATAAAACAAAATTGGACTTAAATGAT
    AAAGAAAGCTTTATAAGTGAAATTAAATCTGCTGTAAATATTGGAGATCAATGTCCGATA
    TGTGGTAATGAAATTCAGGATTTAGGGCATCATATTGATTTTGACAGTATTGCTAAACGT
    CAAAATGAAATTAAAGAAATTGAAGCAAATATCCACGCTATAAAATCGAATATTGCTGTG
    CATAATTCTGAAATTAAATTTGTTAATGAAAAAATATCGAATATTAATATTAAAACGCAA
    AGTGATTTTTCACTTGAAGTATTGAATAAGCGTCTGCTAGAAAATGAAAATGCATTGAAT
    AATCAAAGAGATCTTAATAAATTTATAGAACAAATGAAAGAAGAAAAAGATAATCTAACG
    TTGCAAATTCATAATAAACAATTGCGTCTAAATAAAAATGAATCTGAGTTGAAATTATGT
    CGAGATCTCATCACTGAATTTGAAACACTCTCGAAATATAATAATATCACTAATTTTGAG
    GTGGATTATAAGAAGTATGTTCAAGATGTGAATCAGCATCAAGAACTCTCAAAGGAGATT
    GAAGATAAGTTAATGCAATTGTCTCAAAGAAAGTTAATTGAGCAAAATAATCTAAATCAT
    TATGAAAATCAACTAGAAACTTACAATAATGACTTAGAATTGAATGAACAGTCTATTGAA
    ATGGAAATGTCGAGGCTGAATTTAACTGATGACAATGATATAGATGAAATAATAGCCTGG
    AGGGGCGAGCAAGAGGAATTAGAGCAGAAAAGGGATACTTATAAAAAACGTTATCATGAA
    TTTGAAATGGAAATAGCTAGGTTAGAATCATTAACTAAGGATAAAGAGTTATTGGACTCT
    GATAAATTAAAAGATGAATATGAGCTAAAAAAAGGAAAGATGAATACACTGATAGATGAA
    TACTCTGCTGTTCATTATCAATGTCAAAATAATATTAATAAAACACAATCTATAGTTTCG
    CATATTAATTACTTAAATCAAGAATTAAAGGATCAACAAGAAATATTTCAATTGGCTGAA
    ATTGTCAGTGGTAAGAATAACAAAAATCTTACATTGGAAAACTTTGTCTTAATTTACTAT
    TTAGATCAAATTATTGCTCAAGCAAATCTGAGATTAGCAACAATGTCAGATAATCGATAC
    CAACTAATTAGGCGAGAAGCGGTTTCTCATGGTCTTAGTGGCCTAGAAATTGATGTATTT
    GATTTGCATTCAAATAAGTCTAGACATATTAGCTCGTTATCAGGTGGAGAAACTTTCCAA
    TCGTCGCTTGCATTAGCTTTAGGGTTAAGCGAAATTGTACAGCAGCAATCAGGAGGTATT
    TCACTAGAATCAATATTTATTGATGAAGGATTCGGTACATTAGATCAAGAAACGCTTGAA
    ACAGCGTTAGACACTTTATTAAATCTTAAATCAACTGGTAGAATGGTTGGGATTATTTCA
    CATGTGAGCGAATTGAAAAATAGAATACCTTTAGTTTTAGAAGTGAAATCAGATCAATAT
    CAGAGTTCAACAAGATTCAAAAGAAATTAA
    60
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    3030

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL_RS07035 [old locus tag: SACOL1382 ]
  • symbol: SACOL_RS07035
  • description: nuclease SbcCD subunit C
  • length: 1009
  • theoretical pI: 4.80299
  • theoretical MW: 117317
  • GRAVY: -0.700297

Function[edit source | edit]

  • reaction:
  • TIGRFAM:
    Genetic information processingDNA metabolismDNA replication, recombination, and repairexonuclease SbcC (TIGR00618; HMM-score: 263.3)
    Genetic information processingDNA metabolismRestriction/modificationDNA sulfur modification protein DndD (TIGR03185; HMM-score: 30.7)
    Cellular processesCellular processesCell divisionchromosome segregation protein SMC (TIGR02169; HMM-score: 18.5)
    Genetic information processingDNA metabolismChromosome-associated proteinschromosome segregation protein SMC (TIGR02169; HMM-score: 18.5)
    Cellular processesCellular processesCell divisioncell division ATP-binding protein FtsE (TIGR02673; HMM-score: 18.2)
    type III secretion protein HrpB7 (TIGR02559; HMM-score: 8.7)
    Cellular processesCellular processesCell divisionchromosome segregation protein SMC (TIGR02168; HMM-score: 8.6)
    Genetic information processingDNA metabolismChromosome-associated proteinschromosome segregation protein SMC (TIGR02168; HMM-score: 8.6)
  • TheSEED:
  • PFAM:
    P-loop_NTPase (CL0023) AAA_23; AAA domain (PF13476; HMM-score: 93.3)
    SbcCD_C; Putative exonuclease SbcCD, C subunit (PF13558; HMM-score: 49.3)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 29.1)
    AAA_27; AAA domain (PF13514; HMM-score: 25.8)
    SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 16.4)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 12.3)
    no clan definedDUF3090; Protein of unknown function (DUF3090) (PF11290; HMM-score: 7)
    SRP1_TIP1; Seripauperin and TIP1 family (PF00660; HMM-score: 6.6)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.133
    • Ymax_pos: 61
    • Cmax: 0.154
    • Cmax_pos: 61
    • Smax: 0.199
    • Smax_pos: 8
    • Smean: 0.114
    • D: 0.126
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

  • GI: 446725851 NCBI
  • RefSeq: WP_000803164 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MKPLHLKLNNFGPFLKEEIDFSKIDNNELFLISGKTGSGKTMIFDAMTYALFGKASTEQREENDLRSHFADGKQPMSVTFEFQLNHRIYKVHRQGPYIKEGNTTKTNAKFDVFEMVDGKYEIRESKVISGTQFIIELLGVNADQFRQLFILPQGEFKRFLISNSREKQGILRTLFDSEKFEAIREILKEEVKKEKAQIENRYQQIDLLWQEIESFDDDNIKGLLEVATQQIDKLIENIPLLQARSKEILASVNESKETAIKEFEIIEKKTLENNILKDNINQLNKNKIDFVQLKEQQPEIEGIEAKLKLLQDITNLLNYIENREKIETKIANSKKDISKTNNKILNLDCDKRNIDKEKKMLEENGDLIESKISFIDKTRVLFNDINKYQQSYLNIERLRTEGEQLGDELNDLIKGLETVEDSIGNNQSDYEKIIELNNTITNINNEINIIKENEKAKAELDKLLGSKQELENQINEETSILKNLEIKLDRYDKTKLDLNDKESFISEIKSAVNIGDQCPICGNEIQDLGHHIDFDSIAKRQNEIKEIEANIHAIKSNIAVHNSEIKFVNEKISNINIKTQSDFSLEVLNKRLLENENALNNQRDLNKFIEQMKEEKDNLTLQIHNKQLRLNKNESELKLCRDLITEFETLSKYNNITNFEVDYKKYVQDVNQHQELSKEIEDKLMQLSQRKLIEQNNLNHYENQLETYNNDLELNEQSIEMEMSRLNLTDDNDIDEIIAWRGEQEELEQKRDTYKKRYHEFEMEIARLESLTKDKELLDSDKLKDEYELKKGKMNTLIDEYSAVHYQCQNNINKTQSIVSHINYLNQELKDQQEIFQLAEIVSGKNNKNLTLENFVLIYYLDQIIAQANLRLATMSDNRYQLIRREAVSHGLSGLEIDVFDLHSNKSRHISSLSGGETFQSSLALALGLSEIVQQQSGGISLESIFIDEGFGTLDQETLETALDTLLNLKSTGRMVGIISHVSELKNRIPLVLEVKSDQYQSSTRFKRN

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SACOL_RS07035 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]