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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS10060 [old locus tag: SACOL1924 ]
  • pan locus tag?: SAUPAN004847000
  • symbol: SACOL_RS10060
  • pan gene symbol?:
  • synonym:
  • product: multidrug ABC transporter ATP-binding protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SACOL_RS10060 [old locus tag: SACOL1924 ]
  • symbol: SACOL_RS10060
  • product: multidrug ABC transporter ATP-binding protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1987720..1989456
  • length: 1737
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_002951 (1987720..1989456) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGATTAAACGATATTTGCAATTTGTTAAGCCATACAAATATCGTATTTTTGCAACGATT
    ATTGTTGGGATAATTAAGTTTGGTATACCAATGCTTATACCACTATTAATTAAATATGCA
    ATAGATGGCGTGATTAATAACCACGCACTAACGACTGATGAAAAAGTTCATCATTTAACT
    ATTGCCATTGGTATCGCATTATTTATTTTTGTAATAGTGAGACCACCAATTGAATTTATA
    CGTCAATATTTGGCGCAATGGACAAGTAATAAAATATTGTATGATATACGTAAAAAGTTA
    TACAACCATTTACAAGCTTTAAGTGCGAGATTTTATGCTAATAATCAAGTAGGTCAAGTA
    ATATCTAGAGTGATTAATGATGTTGAACAAACAAAAGATTTCATTTTAACCGGGTTAATG
    AATATTTGGTTAGATTGTATAACAATTATTATTGCACTATCCATAATGTTCTTTTTAGAT
    GTGAAATTGACTTTAGCAGCACTGTTTATCTTCCCATTTTACATTTTAACGGTGTACGTT
    TTCTTTGGAAGATTAAGAAAATTGACACGTGAAAGATCTCAAGCATTAGCTGAGGTTCAA
    GGATTCTTGCATGAACGTGTTCAAGGTATTTCAGTCGTTAAAAGTTTTGCGATTGAAGAC
    AATGAAGCGAAAAACTTTGATAAAAAGAATACTAATTTCCTAACACGTGCGTTGAAACAT
    ACAAGATGGAATGCCTATTCCTTTGCCGCAATTAATACAGTTACAGATATTGGACCAATT
    ATTGTCATCGGTGTTGGTGCATATCTTGCTATTTCTGGATCAATCACAGTAGGTACACTT
    GCAGCATTTGTTGGATACTTAGAGTTATTGTTCGGGCCTTTACGTCGTTTAGTCGCATCA
    TTTACAACTTTAACGCAAAGTTTTGCTTCAATGGACCGTGTATTCCAATTAATTGATGAA
    GATTATGACATCAAAAATGGTGTTGGTGCTCAACCTATTGAAATTAAACAAGGTCGTATT
    GATATTGATCATGTTAGTTTTCAATATAACGATAACGAAGCTCCAATTTTAAAAGATATT
    AATTTGAGTATTGAAAAAGGAGAAACAGTTGCTTTCGTAGGTATGAGTGGTGGTGGTAAA
    TCAACATTAATTAACTTAATACCGAGATTTTACGATGTAACTTCTGGGCAAATTTTAATA
    GATGGTCACAACATTAAAGATTTTTTAACGGGAAGTTTAAGAAATCAAATAGGATTGGTG
    CAACAGGATAATATTTTATTCTCTGATACAGTTAAGGAAAATATTTTACTTGGTCGTCCA
    ACAGCAACAGATGAAGAAGTAGTTGAAGCGGCGAAAATGGCTAATGCACATGACTTTATT
    ATGAACTTGCCACAGGGATATGACACTGAAGTAGGTGAACGAGGTGTTAAATTATCAGGT
    GGTCAAAAACAAAGATTATCGATTGCTAGAATATTTTTAAATAATCCGCCAATTCTTATC
    TTGGATGAAGCAACAAGTGCACTTGATTTAGAAAGTGAATCCATTATTCAAGAAGCATTA
    GATGTGTTGAGTAAAGATCGAACGACACTTATCGTAGCGCATCGCTTGTCCACTATTACA
    CATGCTGACAAAATTGTCGTAATTGAAAATGGACATATTGTTGAAACAGGTACGCATCGT
    GAATTGATTGCAAAACAAGGTGCTTACGAGCATTTATATAGCATTCAAAACTTATAA
    60
    120
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    240
    300
    360
    420
    480
    540
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    660
    720
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    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1737

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SACOL_RS10060 [old locus tag: SACOL1924 ]
  • symbol: SACOL_RS10060
  • description: multidrug ABC transporter ATP-binding protein
  • length: 578
  • theoretical pI: 7.25358
  • theoretical MW: 64862.8
  • GRAVY: 0.196194

Function[edit source | edit]

  • reaction:
    EC 3.6.3.-?  ExPASy
  • TIGRFAM:
    Cell structureCell envelopeBiosynthesis and degradation of surface polysaccharides and lipopolysaccharideslipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 517.4)
    MetabolismTransport and binding proteinsOtherlipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 517.4)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 487.5)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype I secretion system ATPase (TIGR01846; HMM-score: 450.1)
    MetabolismTransport and binding proteinsOtherantigen peptide transporter 2 (TIGR00958; HMM-score: 427.5)
    Cellular processesCellular processesBiosynthesis of natural productsNHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 357.4)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesNHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 357.4)
    Cellular processesCellular processesPathogenesistype I secretion system ATPase (TIGR03375; HMM-score: 355.7)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype I secretion system ATPase (TIGR03375; HMM-score: 355.7)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingABC-type bacteriocin transporter (TIGR01193; HMM-score: 341)
    Genetic information processingProtein fateProtein modification and repairABC-type bacteriocin transporter (TIGR01193; HMM-score: 341)
    MetabolismTransport and binding proteinsOtherABC-type bacteriocin transporter (TIGR01193; HMM-score: 341)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsglucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 326.2)
    Cellular processesCellular processesBiosynthesis of natural productsNHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 313.1)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesNHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 313.1)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 313)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingtype I secretion system ATPase (TIGR01842; HMM-score: 277.1)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 250)
    MetabolismTransport and binding proteinsOthermulti drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 182.6)
    MetabolismTransport and binding proteinsUnknown substrateenergy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 147.1)
    MetabolismTransport and binding proteinsUnknown substrateenergy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 139.7)
    MetabolismTransport and binding proteinsAnionsphosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 135.8)
    MetabolismTransport and binding proteinsAnionsphosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 123.8)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesglycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 123.1)
    Cellular processesCellular processesToxin production and resistanceputative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 118.3)
    MetabolismTransport and binding proteinsUnknown substrateputative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 118.3)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 117.9)
    ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 113.2)
    MetabolismTransport and binding proteinsOtherthiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 112.9)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesputative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 112.8)
    Cellular processesCellular processesCell divisioncell division ATP-binding protein FtsE (TIGR02673; HMM-score: 109.4)
    Genetic information processingProtein fateProtein and peptide secretion and traffickinglipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 108.5)
    MetabolismTransport and binding proteinsCations and iron carrying compoundsnickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 102.5)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesurea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 101.7)
    MetabolismTransport and binding proteinsAnionssulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 100.2)
    D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 99.5)
    2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 97)
    MetabolismTransport and binding proteinsOtherpigment precursor permease (TIGR00955; HMM-score: 96.4)
    MetabolismTransport and binding proteinsOtherdaunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 95.5)
    MetabolismTransport and binding proteinsAnionsmolybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 94.7)
    MetabolismTransport and binding proteinsAnionscystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 94.2)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminescyclic peptide transporter (TIGR01194; HMM-score: 92.9)
    MetabolismTransport and binding proteinsOthercyclic peptide transporter (TIGR01194; HMM-score: 92.9)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 91.3)
    MetabolismTransport and binding proteinsAnionsnitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 90.2)
    MetabolismTransport and binding proteinsOthernitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 90.2)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminespolyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 90.1)
    ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 85.7)
    MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersOtherFeS assembly ATPase SufC (TIGR01978; HMM-score: 84.1)
    Cell structureCell envelopeBiosynthesis and degradation of surface polysaccharides and lipopolysaccharidesLPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 83)
    MetabolismTransport and binding proteinsOtherLPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 83)
    MetabolismTransport and binding proteinsCations and iron carrying compoundscobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 82.5)
    MetabolismTransport and binding proteinsCations and iron carrying compoundsnickel import ATP-binding protein NikD (TIGR02770; HMM-score: 81.8)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminescholine ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 80.7)
    gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 80.2)
    lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 75.7)
    Cellular processesCellular processesOthernodulation ABC transporter NodI (TIGR01288; HMM-score: 75.1)
    MetabolismTransport and binding proteinsOthernodulation ABC transporter NodI (TIGR01288; HMM-score: 75.1)
    MetabolismTransport and binding proteinsAmino acids, peptides and aminesurea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 72.9)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 70.4)
    MetabolismTransport and binding proteinsUnknown substrateanchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 68.9)
    MetabolismEnergy metabolismMethanogenesismethyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 67.3)
    Genetic information processingProtein fateProtein and peptide secretion and traffickingheme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 66.9)
    MetabolismTransport and binding proteinsOtherheme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 66.9)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsD-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 66)
    MetabolismTransport and binding proteinsOtherrim ABC transporter (TIGR01257; HMM-score: 60.7)
    MetabolismTransport and binding proteinsOtherpleiotropic drug resistance family protein (TIGR00956; HMM-score: 56.7)
    MetabolismTransport and binding proteinsCarbohydrates, organic alcohols, and acidsperoxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 54.1)
    ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 49.2)
    MetabolismCentral intermediary metabolismPhosphorus compoundsphosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 40.8)
    Genetic information processingDNA metabolismDNA replication, recombination, and repairexcinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 37.1)
    Genetic information processingProtein synthesisOtherribosome biogenesis GTP-binding protein YsxC (TIGR03598; HMM-score: 13.7)
    Genetic information processingProtein synthesisTranslation factorsribosome small subunit-dependent GTPase A (TIGR00157; EC 3.6.-.-; HMM-score: 13.4)
    Genetic information processingProtein synthesisOtherribosome biogenesis GTPase YqeH (TIGR03597; HMM-score: 13.4)
    MetabolismCentral intermediary metabolismSulfur metabolismadenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 12.5)
    rad50 (TIGR00606; HMM-score: 12.2)
    Cellular processesCellular processesCell divisionchromosome segregation protein SMC (TIGR02168; HMM-score: 9.7)
    Genetic information processingDNA metabolismChromosome-associated proteinschromosome segregation protein SMC (TIGR02168; HMM-score: 9.7)
  • TheSEED:
  • PFAM:
    ABC_membrane (CL0241) ABC_membrane; ABC transporter transmembrane region (PF00664; HMM-score: 163)
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 120.5)
    SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 32.4)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 22.1)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 15.9)
    NTPase_1; NTPase (PF03266; HMM-score: 15)
    MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 14.3)
    ABC_membrane (CL0241) ABC_membrane_3; ABC transporter transmembrane region (PF13748; HMM-score: 13.9)
    P-loop_NTPase (CL0023) AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.3)
    ABC_ATPase; Predicted ATPase of the ABC class (PF09818; HMM-score: 12.5)
    no clan definedPrp19; Prp19/Pso4-like (PF08606; HMM-score: 11.8)
    DUF2207; Predicted membrane protein (DUF2207) (PF09972; HMM-score: 5)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.13
    • Ymax_pos: 16
    • Cmax: 0.133
    • Cmax_pos: 50
    • Smax: 0.295
    • Smax_pos: 6
    • Smean: 0.165
    • D: 0.144
  • predicted transmembrane helices (TMHMM): 5

Accession numbers[edit source | edit]

  • GI: 446519892 NCBI
  • RefSeq: WP_000597238 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MIKRYLQFVKPYKYRIFATIIVGIIKFGIPMLIPLLIKYAIDGVINNHALTTDEKVHHLTIAIGIALFIFVIVRPPIEFIRQYLAQWTSNKILYDIRKKLYNHLQALSARFYANNQVGQVISRVINDVEQTKDFILTGLMNIWLDCITIIIALSIMFFLDVKLTLAALFIFPFYILTVYVFFGRLRKLTRERSQALAEVQGFLHERVQGISVVKSFAIEDNEAKNFDKKNTNFLTRALKHTRWNAYSFAAINTVTDIGPIIVIGVGAYLAISGSITVGTLAAFVGYLELLFGPLRRLVASFTTLTQSFASMDRVFQLIDEDYDIKNGVGAQPIEIKQGRIDIDHVSFQYNDNEAPILKDINLSIEKGETVAFVGMSGGGKSTLINLIPRFYDVTSGQILIDGHNIKDFLTGSLRNQIGLVQQDNILFSDTVKENILLGRPTATDEEVVEAAKMANAHDFIMNLPQGYDTEVGERGVKLSGGQKQRLSIARIFLNNPPILILDEATSALDLESESIIQEALDVLSKDRTTLIVAHRLSTITHADKIVVIENGHIVETGTHRELIAKQGAYEHLYSIQNL

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SACOL_RS10060 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]