NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus USA300_FPR3757
• locus tag: SAUSA300_RS14055 [old locus tag: SAUSA300_2533 ]
• pan locus tag^?: SAUPAN006292000
• symbol: SAUSA300_RS14055
• pan gene symbol^?: panC
• synonym:
• product: pantoate--beta-alanine ligase

⊟Gene

⊟General

• type: CDS
• locus tag: SAUSA300_RS14055 [old locus tag: SAUSA300_2533 ]
• symbol: SAUSA300_RS14055
• product: pantoate--beta-alanine ligase
• replicon: chromosome
• strand: -
• coordinates: 2734055..2734906
• length: 852
• essential: unknown

⊟Accession numbers

• Location: NC_007793 (2734055..2734906) NCBI
• MicrobesOnline:

⊟Phenotype

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⊟DNA sequence

• 1
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  ATGACTAAGCTGATTACTACGGTAAAAGAGATGCAACACATTGTTAAAGCAGCCAAACGC
  TCAGGCACAACGATTGGTTTTATCCCAACAATGGGTGCCTTACATGATGGACATTTAACG
  ATGGTACGCGAATCAGTTAGTACAAATGATATTACAATTGTGAGTGTATTTGTTAATCCA
  TTACAATTTGGTCCAAACGAAGATTTCGATGCTTATCCGAGACAAATTGATAAAGATTTA
  GAATTAGTATCAGAAGTAGGAGCGGACATTGTTTTTCATCCTGCAGTAGAAGATATGTAT
  CCAGGTGAATTAGGTATTGATGTCAAAGTAGGCCCATTAGCTGATGTGTTAGAAGGAGCG
  AAGCGTCCAGGGCATTTTGATGGGGTGGTAACAGTAGTTAATAAGCTATTTAATATTGTT
  ATGCCGGATTATGCTTATTTTGGTAAAAAAGATGCCCAGCAATTGGCTATTGTCGAGCAA
  ATGGTAAAAGACTTCAATCATGCCGTTGAAATTATTGGTATTGATATCGTTCGAGAAGCA
  GATGGTTTGGCGAAAAGTTCAAGAAATGTTTATTTAACGGAGCAAGAACGACAAGAAGCG
  GTACATTTAAGTAAAAGTTTGCTATTAGCACAAGCGTTGTATCAAGACGGTGAACGTCAA
  AGTAAAGTAATTATAGACAGGGTTACTGAATATCTTGAATCACATATAAGTGGACGCATT
  GAAGAAGTTGCTGTTTATAGTTATCCTCAATTAGTAGAACAACACGAAATAACTGGACGC
  ATATTTATCTCGTTAGCTGTTAAATTTTCAAAAGCGCGTTTAATAGATAATATAATAATT
  GGAGCTGAATAA
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⊟Protein

⊟General

• locus tag: SAUSA300_RS14055 [old locus tag: SAUSA300_2533 ]
• symbol: SAUSA300_RS14055
• description: pantoate--beta-alanine ligase
• length: 283
• theoretical pI: 4.95781
• theoretical MW: 31461.8
• GRAVY: -0.0208481

⊟Function

• reaction:
  EC 6.3.2.1?  ExPASy
  Pantoate--beta-alanine ligase (AMP-forming)ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
• TIGRFAM:
  MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersPantothenate and coenzyme Apantoate--beta-alanine ligase (TIGR00018; EC 6.3.2.1; HMM-score: 345.7)
  cytidyltransferase-like domain (TIGR00125; HMM-score: 28.1)
• TheSEED:
• PFAM:
  HUP (CL0039) Pantoate_ligase; Pantoate-beta-alanine ligase (PF02569; HMM-score: 329.1)
  Pec_lyase-like (CL0268) Haemagg_act; haemagglutination activity domain (PF05860; HMM-score: 12.3)

⊟Structure, modifications & interactions

• domains:
• modifications:
• cofactors:
• effectors:
• protein partners:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• LocateP:
• SignalP: no predicted signal peptide
  • Ymax: 0.242
  • Ymax_pos: 18
  • Cmax: 0.134
  • Cmax_pos: 18
  • Smax: 0.553
  • Smax_pos: 11
  • Smean: 0.382
  • D: 0.297
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446085880 NCBI
• RefSeq: WP_000163735 NCBI
• UniProt:

⊟Protein sequence

• MTKLITTVKEMQHIVKAAKRSGTTIGFIPTMGALHDGHLTMVRESVSTNDITIVSVFVNPLQFGPNEDFDAYPRQIDKDLELVSEVGADIVFHPAVEDMYPGELGIDVKVGPLADVLEGAKRPGHFDGVVTVVNKLFNIVMPDYAYFGKKDAQQLAIVEQMVKDFNHAVEIIGIDIVREADGLAKSSRNVYLTEQERQEAVHLSKSLLLAQALYQDGERQSKVIIDRVTEYLESHISGRIEEVAVYSYPQLVEQHEITGRIFISLAVKFSKARLIDNIIIGAE

⊟Experimental data

• experimentally validated: no data available

⊟Expression & Regulation

⊟Operon

• SAUSA300_RS14055 no polycistronic organisation predicted

⊟Regulation

• sigma factor:
• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: no data available

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Other Information

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