NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA_RS03865 [old locus tag: SA0679 ]
• pan locus tag^?: SAUPAN002611000
• symbol: SA_RS03865
• pan gene symbol^?: hisC
• synonym:
• product: histidinol-phosphate aminotransferase

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS03865 [old locus tag: SA0679 ]
• symbol: SA_RS03865
• product: histidinol-phosphate aminotransferase
• replicon: chromosome
• strand: +
• coordinates: 775072..776130
• length: 1059
• essential: unknown

⊟Accession numbers

• Location: NC_002745 (775072..776130) NCBI
• MicrobesOnline:

⊟Phenotype

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⊟DNA sequence

• 1
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  121
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  481
  541
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  841
  901
  961
  1021
  
  ATGAAAGAACAACTTAATCAACTATCAGCATATCAGCCTGGTTTATCTCCAAGGGCATTG
  AAAGAAAAGTATGGCATTGAAGGAGATTTATATAAACTTGCATCAAATGAAAATTTGTAT
  GGACCATCGCCTAAAGTTAAAGAAGCGATATCAGCACATTTAGATGAGTTATATTATTAT
  CCTGAAACAGGATCACCGACATTAAAAGCGGCGATTAGTAAACATTTAAATGTAGATCAA
  TCACGCATTTTATTTGGTGCGGGATTAGATGAAGTTATATTAATGATTTCTAGAGCAGTA
  TTAACGCCAGGGGATACTATTGTTACAAGTGAAGCGACATTCGGTCAATATTATCACAAT
  GCGATTGTTGAATCAGCTAATGTGATACAAGTACCTTTAAAAGATGGTGGCTTCGATTTA
  GAAGGTATTTTAAAAGAAGTTAATGAAGATACGTCATTGGTATGGTTATGTAATCCAAAT
  AATCCTACAGGTACATATTTTAATCATGAGAGCTTAGATTCGTTTTTATCTCAAGTACCT
  CCACATGTACCAGTAATTATAGATGAAGCTTATTTTGAATTTGTGACAGCAGAGGACTAC
  CCGGATACACTTGCTTTGCAACAAAAATATGACAATGCTTTCTTATTACGTACATTTTCA
  AAGGCGTATGGATTAGCGGGTTTACGTGTAGGATATGTGGTAGCAAGTGAACATGCGATT
  GAAAAATGGAACATCATTAGACCACCATTTAATGTGACACGTATATCTGAATACGCAGCA
  GTTGCAGCACTTGAAGATCAACAATATTTAAAAGAGGTAACACATAAAAATAGTGTTGAA
  CGCGAAAGATTTTATCAATTACCTCAAAGTGAGTATTTCTTGCCAAGTCAAACGAATTTT
  ATATTTGTAAAAACAAAGCGGGTAAATGAACTTTATGAAGCACTTTTAAATGTAGGGTGT
  ATTACGCGACCATTTCCAACTGGTGTTAGAATTACAATTGGTTTTAAAGAACAAAATGAT
  AAAATGTTAGAAGTTTTATCAAATTTTAAATACGAATAG
  60
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  1059
  

⊟Protein

⊟General

• locus tag: SA_RS03865 [old locus tag: SA0679 ]
• symbol: SA_RS03865
• description: histidinol-phosphate aminotransferase
• length: 352
• theoretical pI: 4.84534
• theoretical MW: 39787.8
• GRAVY: -0.258239

⊟Function

• reaction:
  EC 2.6.1.9?  ExPASy
  Histidinol-phosphate transaminaseL-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
• TIGRFAM:
  MetabolismAmino acid biosynthesisHistidine familyhistidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 305.7)
  MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersHeme, porphyrin, and cobalaminthreonine-phosphate decarboxylase (TIGR01140; EC 4.1.1.81; HMM-score: 182)
  Cellular processesCellular processesBiosynthesis of natural productscapreomycidine synthase (TIGR03947; HMM-score: 77.6)
  beta-methylarginine biosynthesis bifunctional aminotransferase (TIGR04544; EC 2.6.-.-; HMM-score: 62.1)
  LL-diaminopimelate aminotransferase (TIGR03540; EC 2.6.1.83; HMM-score: 60.9)
  succinyldiaminopimelate transaminase (TIGR03538; EC 2.6.1.17; HMM-score: 59.1)
  succinyldiaminopimelate transaminase (TIGR03537; EC 2.6.1.17; HMM-score: 58.7)
  putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 53.1)
  LL-diaminopimelate aminotransferase (TIGR03542; EC 2.6.1.83; HMM-score: 50.4)
  tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 49.6)
  succinyldiaminopimelate transaminase (TIGR03539; EC 2.6.1.17; HMM-score: 44.8)
  MetabolismEnergy metabolismAmino acids and aminestyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 37.7)
  enduracididine biosynthesis enzyme MppP (TIGR04462; EC 2.-.-.-; HMM-score: 24.6)
  enduracididine biosynthesis enzyme MppQ (TIGR04461; EC 2.-.-.-; HMM-score: 22)
  MetabolismEnergy metabolismAmino acids and aminesaspartate 4-decarboxylase (TIGR03801; EC 4.1.1.12; HMM-score: 19.9)
  cystathionine beta-lyase (TIGR01329; EC 4.4.1.8; HMM-score: 18.8)
• TheSEED:
• PFAM:
  PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 167.5)
  Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 20.6)
  Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 18.8)
  Aminotran_MocR; Alanine-glyoxylate amino-transferase (PF12897; HMM-score: 17.4)
  Alliinase_C; Allinase (PF04864; HMM-score: 13.4)

⊟Structure, modifications & interactions

• domains:
• modifications:
• cofactors: pyridoxal 5'-phosphate
• effectors:
• protein partners:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• LocateP:
• SignalP: no predicted signal peptide
  • Ymax: 0.126
  • Ymax_pos: 26
  • Cmax: 0.112
  • Cmax_pos: 26
  • Smax: 0.195
  • Smax_pos: 9
  • Smean: 0.144
  • D: 0.133
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446585684 NCBI
• RefSeq: WP_000663030 NCBI
• UniProt:

⊟Protein sequence

• MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQSRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAIEKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVTHKNSVERERFYQLPQSEYFLPSQTNFIFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE

⊟Experimental data

• experimentally validated: no data available

⊟Expression & Regulation

⊟Operon

• SA_RS03865 no polycistronic organisation predicted

⊟Regulation

• sigma factor:
• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: no data available

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Other Information

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