NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus N315
• locus tag: SA_RS09080 [old locus tag: SA1614 ]
• pan locus tag^?: SAUPAN004510000
• symbol: SA_RS09080
• pan gene symbol^?: menC
• synonym:
• product: o-succinylbenzoate synthase

⊟Gene

⊟General

• type: CDS
• locus tag: SA_RS09080 [old locus tag: SA1614 ]
• symbol: SA_RS09080
• product: o-succinylbenzoate synthase
• replicon: chromosome
• strand: -
• coordinates: 1848297..1849298
• length: 1002
• essential: unknown

⊟Accession numbers

• Location: NC_002745 (1848297..1849298) NCBI
• MicrobesOnline:

⊟Phenotype

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⊟DNA sequence

• 1
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  ATGAAGTTGACAGCTTTGCATTTTTATAAATATAGTGAGCCATTTAAGTCACAAATTGTA
  ACACCGAAAGTCACTTTAACGCATCGTGATTGTTTGTTTATCGAATTGATTGATGACAAA
  GGAAATGCATATTTCGGGGAATGTAACGCTTTTCAAACAGATTGGTATGATCATGAAACA
  ATTGCTTCAGTGAAACATGTAATTGAGCAATGGTTCGAAGATAATAGAAATAAATCATTT
  GAAACGTATGAAGCAGCACTAAAATTAGTAGATTCATTGGAAAATACGCCTGCTGCAAGG
  GCAACTATTGTCATGGCATTGTATCAAATGTTTCATGTACTGCCTTCATTTTCAGTAGCA
  TATGGAGCGACAGCGAGCGGCTTATCAAATAAACAACTAGAGTCATTGAAAGCAACAAAG
  CCGACCAGAATTAAATTAAAATGGACGCCTCAAATCATGCATCAAATTAGAGTGTTACGG
  GAATTAGACTTTCACTTTCAATTGGTTATAGATGCAAATGAGTCATTGGATCGTCAAGAT
  TTCACACAGTTACAGCTATTAGCGCGTGAACAGGTTCTTTATATCGAAGAGCCATTTAAA
  GATATCTCCATGCTTGATGAAGTAGTGGATGGAACAATACCTCCAATAGCCCTTGATGAA
  AAGGCAACATCGTTGTTGGACATAATTAATTTGATAGAATTATACAATGTGAAAGTTGTT
  GTATTAAAACCATTTCGTCTAGGTGGCATTGATAAAGTGCAAACGGCAATTGATACTTTG
  AAAAGTCATGGTGTAAAAGTGGTTATTGGCGGCATGTACGAATATGGTTTAAGCCGTTAT
  TTTACAGCGATGCTTGCTCGTAAAGGTGATTATCCAGGAGATGTTACACCAGCAGGTTAT
  TATTTTGATCAAGATGTGGTTACTAAATCAGGCATATTAAAAGAGGGGCGACTCGAATTT
  CGCCCCCCTTTAGTGGATATAACTCAATTACAACCATATTAA
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⊟Protein

⊟General

• locus tag: SA_RS09080 [old locus tag: SA1614 ]
• symbol: SA_RS09080
• description: o-succinylbenzoate synthase
• length: 333
• theoretical pI: 5.64797
• theoretical MW: 38030.5
• GRAVY: -0.142042

⊟Function

• reaction:
  EC 4.2.1.113?  ExPASy
  o-succinylbenzoate synthase(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H₂O
• TIGRFAM:
  MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersMenaquinone and ubiquinoneo-succinylbenzoate synthase (TIGR01928; EC 4.2.1.113; HMM-score: 441.3)
  MetabolismBiosynthesis of cofactors, prosthetic groups, and carriersMenaquinone and ubiquinoneo-succinylbenzoate synthase (TIGR01927; EC 4.2.1.113; HMM-score: 83.2)
  muconate and chloromuconate cycloisomerases (TIGR02534; EC 5.5.1.-; HMM-score: 28.7)
  Signal transductionRegulatory functionsDNA interactionsCRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 12.2)
  MetabolismAmino acid biosynthesisAspartate familyS-methyl-5-thioribose-1-phosphate isomerase (TIGR00512; EC 5.3.1.23; HMM-score: 11.9)
• TheSEED:
• PFAM:
  Enolase_TIM (CL0256) MR_MLE_C; Enolase C-terminal domain-like (PF13378; HMM-score: 55.7)
  MAAL_C; Methylaspartate ammonia-lyase C-terminus (PF07476; HMM-score: 14.2)

⊟Structure, modifications & interactions

• domains:
• modifications:
• cofactors: a divalent metal cation
• effectors:
• protein partners:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• LocateP:
• SignalP: no predicted signal peptide
  • Ymax: 0.156
  • Ymax_pos: 18
  • Cmax: 0.112
  • Cmax_pos: 44
  • Smax: 0.309
  • Smax_pos: 10
  • Smean: 0.227
  • D: 0.184
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446701182 NCBI
• RefSeq: WP_000778528 NCBI
• UniProt:

⊟Protein sequence

• MKLTALHFYKYSEPFKSQIVTPKVTLTHRDCLFIELIDDKGNAYFGECNAFQTDWYDHETIASVKHVIEQWFEDNRNKSFETYEAALKLVDSLENTPAARATIVMALYQMFHVLPSFSVAYGATASGLSNKQLESLKATKPTRIKLKWTPQIMHQIRVLRELDFHFQLVIDANESLDRQDFTQLQLLAREQVLYIEEPFKDISMLDEVVDGTIPPIALDEKATSLLDIINLIELYNVKVVVLKPFRLGGIDKVQTAIDTLKSHGVKVVIGGMYEYGLSRYFTAMLARKGDYPGDVTPAGYYFDQDVVTKSGILKEGRLEFRPPLVDITQLQPY

⊟Experimental data

• experimentally validated: no data available

⊟Expression & Regulation

⊟Operon

• SA_RS09080 no polycistronic organisation predicted

⊟Regulation

• sigma factor:
• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: no data available

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Other Information

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