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NCBI: 02-MAR-2017

Summary[edit source | edit]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS11060 [old locus tag: SA1924 ]
  • pan locus tag?: SAUPAN005414000
  • symbol: SA_RS11060
  • pan gene symbol?:
  • synonym:
  • product: aldehyde dehydrogenase family protein

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SA_RS11060 [old locus tag: SA1924 ]
  • symbol: SA_RS11060
  • product: aldehyde dehydrogenase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 2172273..2173700
  • length: 1428
  • essential: unknown

Accession numbers[edit source | edit]

  • Location: NC_002745 (2172273..2173700) NCBI
  • MicrobesOnline:

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGAGAGACTACACAAAGCAATACATTAATGGCGAATGGGTAGAAAGTAATAGTAATGAA
    ACGATAGAAGTTATAAATCCAGCAACCGAAGAAGTAATCGGGAAAGTTGCTAAAGGTAAT
    AAAGCTGATGTTGATAAAGCCGTCGAGGCGGCAGACGATGTTTATTTAGAGTTCCGTCAT
    ACATCTGTGAAAGAAAGACAAGCGTTATTAGATAAAATTGTAAAAGAATATGAAAACAGA
    AAAGACGATATTGTACAAGCTATTACGGATGAATTAGGTGCTCCTTTATCATTATCTGAG
    CGTGTCCATTATCAAATGGGACTAAACCATTTTGTTGCAGCGAGAGACGCATTAGATAAC
    TACGAATTTGAAGAACGCCGCGGAGATGATTTAGTTGTTAAAGAAGCAATCGGTGTATCT
    GGATTAATTACACCGTGGAACTTCCCTACAAACCAAACATCATTAAAATTAGCAGCAGCA
    TTTGCGGCTGGTAGTCCAGTTGTACTTAAACCATCTGAAGAAACACCATTTGCAGCTGTT
    ATTTTAGCTGAGATTTTTGATAAAGTCGGTGTTCCTAAAGGTGTATTTAACCTTGTTAAT
    GGTGATGGTGCTGGTGTTGGGAATCCTTTATCTGAACATCCTAAAGTACGCATGATGTCA
    TTCACAGGATCAGGCCCTACTGGTTCTAAAATTATGGAAAAAGCCGCTAAAGATTTTAAA
    AAGGTATCATTAGAGCTTGGTGGCAAATCACCATATATCGTCCTAGATGACGTAGATATT
    AAAGAAGCGGCTAAAGCAACAACAGGCAAAGTTGTTAATAATACTGGTCAAGTATGTACA
    GCTGGTACACGTGTTTTAGTGCCTAACAAAATTAAAGATGCATTCTTAGCTGAATTAAAA
    GAACAATTTAGCCAAGTGCGTGTCGGTAATCCAAGAGAAGATGGTACACAAGTAGGCCCT
    ATCATTAGTAAAAAACAATTTGATCAAGTACAAAATTATATTAATAAAGGTATTGAAGAA
    GGTGCTGAATTATTTTATGGTGGTCCTGGTAAACCAGAAGGACTTGAAAAAGGATACTTT
    GCACGTCCGACAATTTTTATTAATGTAGATAATCAAATGACGATAGCACAAGAAGAAATT
    TTTGGGCCAGTAATGTCAGTTATCACTTATAACGATTTAGATGAAGCGATTCAAATTGCA
    AATGATACAAAATATGGTTTGGCAGGATATGTTATTGGTAAGGACAAAGAAACATTGCAT
    AAAGTAGCTCGTTCTATTGAAGCAGGTACAGTAGAAATAAACGAAGCAGGTAGAAAGCCA
    GATTTACCATTTGGTGGCTATAAACAATCTGGTTTAGGTCGTGAATGGGGCGATTATGGT
    ATTGAAGAGTTCTTAGAAGTGAAATCTATAGCTGGATATTTTAAATAA
    60
    120
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    1140
    1200
    1260
    1320
    1380
    1428

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SA_RS11060 [old locus tag: SA1924 ]
  • symbol: SA_RS11060
  • description: aldehyde dehydrogenase family protein
  • length: 475
  • theoretical pI: 4.76962
  • theoretical MW: 51968.3
  • GRAVY: -0.350526

Function[edit source | edit]

  • reaction:
    EC 1.2.1.3?  ExPASy
    Aldehyde dehydrogenase (NAD+)An aldehyde + NAD+ + H2O = a carboxylate + NADH
  • TIGRFAM:
    Cellular processesCellular processesAdaptations to atypical conditionsbetaine-aldehyde dehydrogenase (TIGR01804; EC 1.2.1.8; HMM-score: 460)
    5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase (TIGR02299; EC 1.2.1.60; HMM-score: 449.2)
    Unknown functionEnzymes of unknown specificityaldehyde dehydrogenase, Rv0768 family (TIGR04284; EC 1.2.1.-; HMM-score: 405)
    MetabolismCentral intermediary metabolismOthersuccinate-semialdehyde dehydrogenase (TIGR01780; EC 1.2.1.-; HMM-score: 403.8)
    MetabolismEnergy metabolismOther2-hydroxymuconic semialdehyde dehydrogenase (TIGR03216; EC 1.2.1.-; HMM-score: 375.8)
    MetabolismEnergy metabolismAmino acids and aminesputative delta-1-pyrroline-5-carboxylate dehydrogenase (TIGR01237; EC 1.2.1.88; HMM-score: 314.6)
    1-pyrroline dehydrogenase (TIGR03374; EC 1.2.1.19; HMM-score: 293.2)
    MetabolismEnergy metabolismAmino acids and aminesmethylmalonate-semialdehyde dehydrogenase (acylating) (TIGR01722; EC 1.2.1.27; HMM-score: 274.6)
    putative phosphonoacetaldehyde dehydrogenase (TIGR03250; EC 1.2.1.-; HMM-score: 265.1)
    MetabolismEnergy metabolismAmino acids and aminessuccinylglutamate-semialdehyde dehydrogenase (TIGR03240; EC 1.2.1.71; HMM-score: 223.8)
    MetabolismEnergy metabolismAmino acids and aminesdelta-1-pyrroline-5-carboxylate dehydrogenase (TIGR01238; EC 1.2.1.88; HMM-score: 181.5)
    MetabolismEnergy metabolismAmino acids and amines1-pyrroline-5-carboxylate dehydrogenase (TIGR01236; EC 1.2.1.88; HMM-score: 169.2)
    phenylacetic acid degradation protein paaN (TIGR02278; HMM-score: 142.6)
    phenylacetic acid degradation protein paaN (TIGR02288; HMM-score: 48.8)
    acetaldehyde dehydrogenase (acetylating) (TIGR02518; EC 1.2.1.10; HMM-score: 23.1)
  • TheSEED:
  • PFAM:
    ALDH-like (CL0099) Aldedh; Aldehyde dehydrogenase family (PF00171; HMM-score: 552.9)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:
    SA_RS02955elongation factor G  [1] (data from MRSA252)
    SA_RS02960elongation factor Tu  [1] (data from MRSA252)
    SA_RS08560pyruvate kinase  [1] (data from MRSA252)

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • Ymax: 0.103
    • Ymax_pos: 43
    • Cmax: 0.135
    • Cmax_pos: 43
    • Smax: 0.106
    • Smax_pos: 30
    • Smean: 0.075
    • D: 0.092
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

  • GI: 447128837 NCBI
  • RefSeq: WP_001206093 NCBI
  • UniProt:

Protein sequence[edit source | edit]

  • MRDYTKQYINGEWVESNSNETIEVINPATEEVIGKVAKGNKADVDKAVEAADDVYLEFRHTSVKERQALLDKIVKEYENRKDDIVQAITDELGAPLSLSERVHYQMGLNHFVAARDALDNYEFEERRGDDLVVKEAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVVLKPSEETPFAAVILAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEHPKVRMMSFTGSGPTGSKIMEKAAKDFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLVPNKIKDAFLAELKEQFSQVRVGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYGGPGKPEGLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGLAGYVIGKDKETLHKVARSIEAGTVEINEAGRKPDLPFGGYKQSGLGREWGDYGIEEFLEVKSIAGYFK

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

  • SA_RS11060 no polycistronic organisation predicted

Regulation[edit source | edit]

  • sigma factor:
  • regulator:

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

  1. 1.0 1.1 1.2 Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
    Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
    J. Proteome Res.: 2011, 10(3);1139-50
    [PubMed:21166474] [WorldCat.org] [DOI] (I p)

Relevant publications[edit source | edit]