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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002329
  • pan locus tag?: SAUPAN005869000
  • symbol: JSNZ_002329
  • pan gene symbol?: hrtB
  • synonym:
  • product: ABC transporter permease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002329
  • symbol: JSNZ_002329
  • product: ABC transporter permease
  • replicon: chromosome
  • strand: -
  • coordinates: 2326093..2327148
  • length: 1056
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAATTAGCGATAAAAGAGATTATGTTTTACAAATTTCGTTATATTTTAATCACATTA
    ATCATTCTTTTATTAAGTATTATGGTGTTATTTATTAGTGGTTTAGCTCAAGGGCTTGGT
    AGGGAGAATATTTCGTTATTTGAACACTTTGATAATGATGAATATGTTGTTCAAAAAATG
    AAAGAGCCGCAAATTGAGAAATCGCAACTTAGTGATACGCAACAGAATCAAATTAAAAAG
    GTAATTCATCAAGAACCATATAAAATGAATATTCAAACATTGAAATTATCTAATAAAGAA
    CAAGATGTGATTACAATGAATGACGTTAAACAACAACGCATACAACTTAAAAAAGGTGAT
    TATCCTAAAAATGCTCATGAGGTCGCTATTAATGATAAGTTAGCTTCAGACAACATTAGA
    GTCGGGGATAGATTACATTTTAAAAATAATTCAACTAGTTATAGAGTTTCTGGTATTTTA
    AACGACACAATGTATGCGCATAGTTCCATTGTGCTATTGAACGATAACGGATTTAATGCA
    TTGAATAAGGTTAATACGGCATTTTATCCAGTGAAAAATTTAACACAACAACAACGTGAT
    GAGCTTAATAAAATAAATGACGTTCAAGTGGTGAGTGAAAAAGATTTAACAGGTAATATT
    GCGAGTTATCAAGCAGAGCAAGCACCGTTAAATATGATGATTGTTAGTTTGTTTGCTATT
    ACAGCAATCGTTCTAAGTGCATTTTTCTATGTTATGACGATTCAAAAAATATCACAAATT
    GGCATTTTGAAAGCAATTGGTATTAAGACAAGACATTTATTGAGTGCGTTAGTTTTACAA
    ATTTTAACACTAACAATAATTGGGGTAGGTATTGCTGTGATCATCATAGTAGGACTATCA
    TTTATGATGCCGGTAACGATGCCTTTTTACTTAACAACGCAAAATATTTTATTAATGGTG
    GGGATATTTATATTAGTAGCGATTTTAGGTGCCTCACTATCATTTATCAAATTATTTAAA
    GTGGATCCTATCGAAGCAATTGGAGGTGCAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1056

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002329
  • symbol: JSNZ_002329
  • description: ABC transporter permease
  • length: 351
  • theoretical pI: 9.58764
  • theoretical MW: 39497.3
  • GRAVY: 0.257835

⊟Function[edit | edit source]

  • TIGRFAM:
    acidobacterial duplicated orphan permease (TIGR03434; HMM-score: 33.2)
    and 1 more
    Metabolism Transport and binding proteins Other ABC exporter transmembrane subunit, DevC protein (TIGR01185; HMM-score: 17.2)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    BPD_transp_1 (CL0404) FtsX; FtsX-like permease C-terminal (PF02687; HMM-score: 40.2)
    and 4 more
    DPBB (CL0199) MacB_PCD; MacB-like periplasmic core domain (PF12704; HMM-score: 26.3)
    E-set (CL0159) TPPII; Tripeptidyl peptidase II (PF12580; HMM-score: 16.8)
    no clan defined DUF1195; Protein of unknown function (DUF1195) (PF06708; HMM-score: 12.3)
    TERB2; Telomere-associated protein TERB2 (PF15101; HMM-score: 9.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9999
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0001
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.220691
    • TAT(Tat/SPI): 0.001317
    • LIPO(Sec/SPII): 0.060633
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLAIKEIMFYKFRYILITLIILLLSIMVLFISGLAQGLGRENISLFEHFDNDEYVVQKMKEPQIEKSQLSDTQQNQIKKVIHQEPYKMNIQTLKLSNKEQDVITMNDVKQQRIQLKKGDYPKNAHEVAINDKLASDNIRVGDRLHFKNNSTSYRVSGILNDTMYAHSSIVLLNDNGFNALNKVNTAFYPVKNLTQQQRDELNKINDVQVVSEKDLTGNIASYQAEQAPLNMMIVSLFAITAIVLSAFFYVMTIQKISQIGILKAIGIKTRHLLSALVLQILTLTIIGVGIAVIIIVGLSFMMPVTMPFYLTTQNILLMVGIFILVAILGASLSFIKLFKVDPIEAIGGAE

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: HssR (activation) regulon
    HssR(TF)important in Heme efflux;  regulation predicted or transferred from N315 and NCTC 8325  [2]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)
  2. ↑ Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker
    Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ.
    Curr Res Microb Sci: 2025, 9;100489
    [PubMed:41146725] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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