PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_002478
• pan locus tag^?: SAUPAN006096000
• symbol: galU
• pan gene symbol^?: gtaB
• synonym:
• product: UTP--glucose-1-phosphate uridylyltransferase GalU

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_002478
• symbol: galU
• product: UTP--glucose-1-phosphate uridylyltransferase GalU
• replicon: chromosome
• strand: -
• coordinates: 2479004..2479870
• length: 867
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  
  TTGAAAAAAATAAAAAAGGCAATCATTCCCGCTGCTGGTTTAGGGACTAGATTTTTACCA
  GCAACTAAAGCGATGCCAAAGGAAATGCTTCCTATCTTAGATAAACCCACAATACAATAT
  ATCGTTGAAGAAGCTGCAAGAGCTGGAATTGAAGATATTATTATAGTGACAGGTCGCCAC
  AAACGCGCGATTGAAGATCATTTTGATAGTCAAAAAGAATTAGAAATGGTGTTAAAAGAA
  AAAGGTAAATCTGAATTACTAGAAAAAGTTCAATACTCGACAGAACTTGCGAATATTTTT
  TATGTAAGGCAGAAAGAACAAAAAGGTTTAGGGCATGCGATTAGTTCTGCGCGTCAATTT
  ATCGGCAATGAACCATTTGCGGTATTATTAGGTGACGATATTGTTGAATCTGAAGTGCCA
  GCAGTGAAACAGTTGATTGACGTTTATGAAGAAACAGGGCACTCAGTTATAGGTGTCCAA
  GAAGTTCCGGAAGCAGATACTCATCGTTATGGAATTATTGACCCATTAACTAAAAACGGA
  CGTCAGTATGAAGTGAAAAAGTTTGTTGAAAAGCCAGCACAAGGTACGGCACCATCAAAC
  CTAGCTATTATGGGACGTTATGTATTAACGCCTGAAATTTTCGATTATTTAAAAACGCAA
  AAAGAAGGCGCAGGTAACGAAATTCAGTTAACAGATGCGATTGAACGTATGAATAATGAT
  AACCAAGTGTATGCATATGACTTCGAAGGCGAACGTTATGACGTTGGAGAAAAATTAGGC
  TTCGTTAAAACTACCATAGAATATGCATTGAAAGATGACAGTATGCGAGAAGAATTAACA
  CGATTTATTAAAGCATTAGGTTTATAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  867
  

⊟Protein

⊟General

• locus tag: JSNZ_002478
• symbol: GalU
• description: UTP--glucose-1-phosphate uridylyltransferase GalU
• length: 288
• theoretical pI: 5.17656
• theoretical MW: 32451
• GRAVY: -0.390278

⊟Function

• reaction:
  EC 2.7.7.9?  ExPASy
  UTP--glucose-1-phosphate uridylyltransferase UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
• TIGRFAM:
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UTP--glucose-1-phosphate uridylyltransferase (TIGR01099; EC 2.7.7.9; HMM-score: 400.7)
  and 13 more
  Signal transduction Regulatory functions Protein interactions regulatory protein GalF (TIGR01105; HMM-score: 208.3)
  glucose-1-phosphate thymidylyltransferase (TIGR01208; EC 2.7.7.24; HMM-score: 142)
  UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR03992; EC 2.3.1.157,2.7.7.23; HMM-score: 140.7)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides glucose-1-phosphate thymidylyltransferase (TIGR01207; EC 2.7.7.24; HMM-score: 71.8)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides glucose-1-phosphate cytidylyltransferase (TIGR02623; EC 2.7.7.33; HMM-score: 59.2)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 58.2)
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 58.2)
  Metabolism Central intermediary metabolism Amino sugars UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 58.2)
  Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides glucose-1-phosphate adenylyltransferase (TIGR02091; EC 2.7.7.27; HMM-score: 51.9)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TIGR00453; EC 2.7.7.60; HMM-score: 25.8)
  molybdenum cofactor cytidylyltransferase (TIGR03310; EC 2.7.7.76; HMM-score: 24.1)
  Hypothetical proteins Conserved TIGR00454 family protein (TIGR00454; HMM-score: 19.2)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase (TIGR01479; EC 2.7.7.13,5.3.1.8; HMM-score: 18)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  GT-A (CL0110) NTP_transferase; Nucleotidyl transferase (PF00483; HMM-score: 132.1)
  and 3 more
  NTP_transf_3; MobA-like NTP transferase domain (PF12804; HMM-score: 36.7)
  IspD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (PF01128; HMM-score: 19.9)
  Glycos_transf_2; Glycosyl transferase family 2 (PF00535; HMM-score: 13)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.8359
  • Cytoplasmic Membrane Score: 0.161
  • Cell wall & surface Score: 0.0005
  • Extracellular Score: 0.0025
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.151514
  • TAT(Tat/SPI): 0.012724
  • LIPO(Sec/SPII): 0.004424
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MKKIKKAIIPAAGLGTRFLPATKAMPKEMLPILDKPTIQYIVEEAARAGIEDIIIVTGRHKRAIEDHFDSQKELEMVLKEKGKSELLEKVQYSTELANIFYVRQKEQKGLGHAISSARQFIGNEPFAVLLGDDIVESEVPAVKQLIDVYEETGHSVIGVQEVPEADTHRYGIIDPLTKNGRQYEVKKFVEKPAQGTAPSNLAIMGRYVLTPEIFDYLKTQKEGAGNEIQLTDAIERMNNDNQVYAYDFEGERYDVGEKLGFVKTTIEYALKDDSMREELTRFIKALGL

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications