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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002570
  • pan locus tag?: SAUPAN006269000
  • symbol: JSNZ_002570
  • pan gene symbol?: pyrD
  • synonym:
  • product: quinone-dependent dihydroorotate dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002570
  • symbol: JSNZ_002570
  • product: quinone-dependent dihydroorotate dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 2576475..2577539
  • length: 1065
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGTACAAATTAATTAAACCTTTCTTATTCAAAATCGAACCCGAAAAAGCACACGGACTA
    ACTATCGATGCATTAAAAACGTTACAAAAGTTTCCGGTTTTATTCCCAGTCGTCGATAAA
    CTATTTACTTATAAGAATCCAACGTTATCACAAACGATACAAGGTAATACGTACGACAAT
    CCAATTGGCTTAGCAGCTGGTTTCGACAAATCTTGCGAAGTACCAAAAGCATTGGAACAC
    CTTGGATTCGGTGCTTTAGAATTAGGTGGTATCACACCTAAACCTCAACCGGGTAACCCT
    CAACCACGCATGTTTAGATTATTAGAAGATGACGCCTTGATAAATCGAATGGGCTTCAAT
    AATATTGGTATGAACAAAGCACTAAGTCATTTGCGTAAAAATGCTTATCAAGTACCTGTT
    GGTATCAATGTTGGTGTGAATAAAATGACACCTTATGAAGCGCGTTATCAAGATTATATA
    AAGGTTATTGATACGTTTAAACACGACGTTTCATTTTTCACAGTCAACATCAGTTCTCCA
    AATACTGAAAATCTTCAAAACTTCCATGATAAAGATGAATTTTCAATGTTATGCCAAGCT
    TTAACAGCATTTAAAAAACAACATGATGTAACAGTGCCAATTTATTTAAAACTAACGTCT
    GATATGGATTTCGATGGCTTAAAAGCACTATTACCAGCGATTACTGAGACATTTGACGGT
    ATCATCTTAGCAAACACAACGCGACAACGAGATGGTTTAACTTCTGCTAATAAAGTCGAA
    GAAGGCGGTTTGAGTGGTCGTCCATTATTTGAACGTAATTTAAAATTGATTAAGTATGCT
    TATCAGCAAACAAATGGTGAATTTTTAATTATAGGTACAGGCGGCGTATTCAGTACTGAA
    GATGCAATCAAAATGATGCGTCACGGTGCGTCACTTATTCAAATTTATTCATCACTTGTT
    ATTGAAGGCCCAGGTTTAACTAAGAAAATGAACAAAGGCATCGCACGTTACTTAAAGGAT
    CATCATTTTGACAATGTCAGTGATATTATAGGACTAGATGCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1065

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002570
  • symbol: JSNZ_002570
  • description: quinone-dependent dihydroorotate dehydrogenase
  • length: 354
  • theoretical pI: 8.56958
  • theoretical MW: 39536.3
  • GRAVY: -0.222599

⊟Function[edit | edit source]

  • reaction:
    EC 1.3.5.2?  ExPASy
    Dihydroorotate dehydrogenase (quinone) (S)-dihydroorotate + a quinone = orotate + a quinol
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis dihydroorotate dehydrogenase (fumarate) (TIGR01036; EC 1.3.98.1; HMM-score: 328.6)
    and 2 more
    dihydroorotate dehydrogenase family protein (TIGR01037; EC 1.3.-.-; HMM-score: 100.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other isopentenyl-diphosphate delta-isomerase, type 2 (TIGR02151; EC 5.3.3.2; HMM-score: 11)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    TIM_barrel (CL0036) DHO_dh; Dihydroorotate dehydrogenase (PF01180; HMM-score: 232.4)
    and 1 more
    UBA (CL0214) UBA_NBR1_C; Next to BRCA1 gene 1 protein-like, C-terminal UBA domain (PF24932; HMM-score: 15.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0801
    • Cytoplasmic Membrane Score: 0.8597
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0601
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004344
    • TAT(Tat/SPI): 0.00029
    • LIPO(Sec/SPII): 0.000607
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDNPIGLAAGFDKSCEVPKALEHLGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFNNIGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYIKVIDTFKHDVSFFTVNISSPNTENLQNFHDKDEFSMLCQALTAFKKQHDVTVPIYLKLTSDMDFDGLKALLPAITETFDGIILANTTRQRDGLTSANKVEEGGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTGGVFSTEDAIKMMRHGASLIQIYSSLVIEGPGLTKKMNKGIARYLKDHHFDNVSDIIGLDA

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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