PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

FunGene: 08-OCT-2024

⊟Summary

• organism: Staphylococcus aureus JSNZ
• locus tag: JSNZ_002633
• pan locus tag^?: SAUPAN006374000
• symbol: JSNZ_002633
• pan gene symbol^?: —
• synonym:
• product: YhgE/Pip family protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: JSNZ_002633
• symbol: JSNZ_002633
• product: YhgE/Pip family protein
• replicon: chromosome
• strand: -
• coordinates: 2640808..2643780
• length: 2973
• essential: unknown other strains

⊟Accession numbers

• Gene ID:
• RefSeq:
• BioCyc:
• MicrobesOnline:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  1381
  1441
  1501
  1561
  1621
  1681
  1741
  1801
  1861
  1921
  1981
  2041
  2101
  2161
  2221
  2281
  2341
  2401
  2461
  2521
  2581
  2641
  2701
  2761
  2821
  2881
  2941
  
  ATGAAGAACGCATTTAAATTATTTAAAATGGATCTGAAGAAAGTAGCTAAGACGCCAGCT
  GTGTGGATTATCTTAGCAGGCTTAGCTATTTTGCCATCGTTCTACGCTTGGTTTAACTTA
  TGGGCAATGTGGGATCCATATGGCAACACGGGACACATCAAGGTCGCAGTCGTTAATGAA
  GATAAAGGCGACACAATCAGAGGGAAAAAAGTTAATGTCGGTAATACGATGGTTAATACA
  CTCAAGAAAAATAAAAGTTTTGATTGGCAGTTTGTAAGTAGAGAGAAAGCTGATCATGAG
  ATAAAAATGGGTAAATATTTTGCAGGTATTTACATCCCATCTAAGTTTACACATGAAATT
  ACCGGGACACTACGTAAGCAGCCTCAAAAAGCAGATGTAGAATTTAAGGTGAATCAGAAG
  ATTAACGCTGTTGCGTCTAAGCTAACAGATACTGGTTCGTCAGTTGTCGTTGAAAAAGCG
  AATGAACAATTTAATAAAACAGTAACTCGAGCATTATTAGAAGAAGCTAACAAAGCAGGT
  TTAACTATTGAAGAAAATGTGCCGACAATTAATAAGATAAAAAATGCGGTATATTCGGCA
  GATAAAGCTTTACCTAAGATTAATGACTTTGCGAATAAAATTGTATATTTGAATAACCAC
  CAAGCGGATTTAGATAAATATGCCAATGATTTTAGAAAACTAGGAAATTATAAAGGTGAT
  ATTTTAGATGCTCAGAAAAAATTAAACGAAGTCAATGGTGCTATTCCGCAACTTAATGAA
  AAGGCTAAGTTGATATTAGCTTTAAATAATTATATGCCGAAAATTGAAAAAGCGTTAAAT
  TTTGCAGCTGATGACGTGCCAGCGCAGTTCCCTAAAATTAATCAAGGACTTAACATTGCG
  AGTCAAGGGATTGATCAAGCTAATGGACAGTTAAATGATGCCAAAGGCTTCGTCACACAA
  GTTAGAAGTAGAGTCGGTGATTATCAAGATGCAATTCGACGCGCGCAAGATTTAAATCGA
  AGAAACCAGCAACAGATTCCTCAAAATAGCGCGGCGAACAACGAAACATCAAATAGTGCA
  CCTGCAGCTGGTAATGGTGTAGCATCAACGCCACCAAGTGGCGATACTGCACCAAATAAT
  AATGTTCCGCAAAATACCGCACCAAATAGTAATAATGCGCCTGTATCGACTACACCACAA
  AGTACAAGCGGGAAAAAAGATGGTCAAAGTTTTGCAGATATAACAACAACACAAGTCAGC
  ACAGCTAACGAGAACACACAAAACATTACAGATAAAGATGTTAAATCAATGGAAGCGGCA
  TTAACGGGCTCTTTATTATCATTATCAAATAATTTAGATACCCAAGCGAAAGCCGCACAA
  AAAGATAGTCAGACATTACGTAATATTTCGTATGGCATTTTAGCATCGGACAAGCCTTCT
  GATTTTAGAGAGTCTTTAGATAATGTTAAGTCCGGTTTAGAATACACAACGCAATATAAT
  CAACAATTTATCGATACATTAAAAGAGATTGAGAAGAATGAAAATGTTGATTTATCAAAA
  GAAATTGATAAGGTAAAAGCAGCTAATAATCGAATTAATGAATCATTAAGGTTAGTTAAT
  CAATTAAGCAATGCATTAAAGAATGGTAGTTCAGGAACTGCTGAAGCTACTAAATTACTA
  GATCAACTTTCAAAACTAGATTCATCATTATCATCATTTAGAGATTATGTTAAAAAAGAT
  CTTAACAGCTCTTTAGTATCAATATCACAACGTATTATGGATGAATTGAACAAAGGGCAA
  ACTGCATTATCCAATGTTCAGTCTAAATTAAATACAATTGATCAAGTCATTAACAGTGGA
  CAAGCTATTTTAAAAAATGGTAAAACACGTATTGATCGCTTACAAACAGTATTACCAAGT
  ATTGAACAACAATACATTAGTGCTGTTAAAAATGCTCAAGCAAACTTCCCGAAAGTGAAA
  AGTGATGTAGCTAAAGCTGCTAACTTTGTGCGCAATGACTTACCACAGTTGGAACAGCGA
  TTAACTAATGCGACAGCAAGTGTGAATAAAAATTTACCAACGTTATTAAATGGTTATGAT
  CAAGCGGTAGGATTACTAAATAAAAATCAGCCACAAGCGAAAAAGGCTTTATCAGATTTA
  GCTGATTTTTCTCAAAATAAATTGCCTGATGTTGAAAAAGATTTGAAAAAAGCGAATAAA
  ATTTTCAAGAAATTAGACAAAGATGATGCAGTCGACAAATTAATCGACACACTTAAGAAT
  GATTTGAAAAAGCAAGCGGGTATTATTGCAAATCCTATTAATAAGAAGACTGTTGATGTT
  TTCCCAGTTAAGGATTATGGTTCAGGTATGACACCATTCTATACTGCACTGTCAGTATGG
  GTAGGTGCACTCTTGATGGTAAGTTTATTAACGGTTGATAATAAACATAAGAGTCTAGAG
  TCAGTCTTAACGACAAGACAAGTGTTCTTAGGTAAGGCAGGATTCTTTATAATGCTTGGT
  ATGTTGCAAGCACTCATTGTATCGGTTGGAGATTTGTTAATCCTAAAAGCAGGAGTTGAG
  TCACCTGTATTATTTGTACTTATAACGATTTTCTGTTCGATTATTTTCAACTCAATCGTA
  TATACGTGCGTATCATTACTTGGTAATCCAGGTAAAGCCATTGCAATCGTATTGCTTGTA
  TTACAAATTGCAGGTGGTGGAGGAACATTCCCAATTCAAACTACGCCACAATTTTTCCAA
  AACATTTCGCCATACTTACCATTTACGTATGCAATTGATTCATTACGTGAAACAGTAGGC
  GGTATTGTTCCGGAAATCCTAATTACAAAATTAATTATATTAACGTTATTTGGCATAGGA
  TTCTTCGTTGTAGGTTTAATTTTAAAACCTGTAACAGATCCATTGATGAAGCGCGTATCT
  GAAAAAGTTGACCAAAGTAACGTTACAGAATAA
  60
  120
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  1260
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  1560
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  2160
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  2520
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  2640
  2700
  2760
  2820
  2880
  2940
  2973
  

⊟Protein

⊟General

• locus tag: JSNZ_002633
• symbol: JSNZ_002633
• description: YhgE/Pip family protein
• length: 990
• theoretical pI: 9.90943
• theoretical MW: 108468
• GRAVY: -0.286162

⊟Function

• TIGRFAM:
  YhgE/Pip C-terminal domain (TIGR03062; HMM-score: 167.6)
  YhgE/Pip N-terminal domain (TIGR03061; HMM-score: 156.2)
  and 3 more
  type VII secretion protein EsaA (TIGR03929; HMM-score: 83.4)
  Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter membrane protein (TIGR01247; HMM-score: 20.7)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking twin arginine-targeting protein translocase, TatA/E family (TIGR01411; HMM-score: 6.2)
• TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
• PFAM:
  ABC-2 (CL0181) ABC2_membrane_3; ABC-2 family transporter protein (PF12698; HMM-score: 86.7)
  and 12 more
  ABC2_membrane; ABC-2 type transporter (PF01061; HMM-score: 31.3)
  DUF3533; Protein of unknown function (DUF3533) (PF12051; HMM-score: 22.6)
  no clan defined ADIP; Afadin- and alpha -actinin-Binding (PF11559; HMM-score: 17.3)
  Baculo_PEP_C; Baculovirus polyhedron envelope protein, PEP, C terminus (PF04513; HMM-score: 16.3)
  DUF842; Eukaryotic protein of unknown function (DUF842) (PF05811; HMM-score: 13.3)
  Globin (CL0090) HisK-N-like; HisK-N-like globin domain of the ASK signalosome (PF20302; HMM-score: 12.6)
  SNARE-fusion (CL0445) V-SNARE_C; Snare region anchored in the vesicle membrane C-terminus (PF12352; HMM-score: 11)
  no clan defined DUF2203; Uncharacterized conserved protein (DUF2203) (PF09969; HMM-score: 9.7)
  EsxAB (CL0352) Hydro_N_hd; Hydrolase N-terminal helical domain (PF22905; HMM-score: 9.3)
  no clan defined DUF2935; Domain of unknown function (DUF2935) (PF11155; HMM-score: 7.9)
  SNARE-fusion (CL0445) Sec20; Sec20 (PF03908; HMM-score: 7.6)
  no clan defined Prominin; Prominin (PF05478; HMM-score: 5.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 9.99
  • Cellwall Score: 0.01
  • Extracellular Score: 0.01
  • Internal Helices: 6
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.0002
  • Cytoplasmic Membrane Score: 0.9881
  • Cell wall & surface Score: 0.0068
  • Extracellular Score: 0.005
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.069564
  • TAT(Tat/SPI): 0.001126
  • LIPO(Sec/SPII): 0.006006
• predicted transmembrane helices (TMHMM): 6

⊟Accession numbers

• GI:
• RefSeq:
• UniProt:

⊟Protein sequence

• MKNAFKLFKMDLKKVAKTPAVWIILAGLAILPSFYAWFNLWAMWDPYGNTGHIKVAVVNEDKGDTIRGKKVNVGNTMVNTLKKNKSFDWQFVSREKADHEIKMGKYFAGIYIPSKFTHEITGTLRKQPQKADVEFKVNQKINAVASKLTDTGSSVVVEKANEQFNKTVTRALLEEANKAGLTIEENVPTINKIKNAVYSADKALPKINDFANKIVYLNNHQADLDKYANDFRKLGNYKGDILDAQKKLNEVNGAIPQLNEKAKLILALNNYMPKIEKALNFAADDVPAQFPKINQGLNIASQGIDQANGQLNDAKGFVTQVRSRVGDYQDAIRRAQDLNRRNQQQIPQNSAANNETSNSAPAAGNGVASTPPSGDTAPNNNVPQNTAPNSNNAPVSTTPQSTSGKKDGQSFADITTTQVSTANENTQNITDKDVKSMEAALTGSLLSLSNNLDTQAKAAQKDSQTLRNISYGILASDKPSDFRESLDNVKSGLEYTTQYNQQFIDTLKEIEKNENVDLSKEIDKVKAANNRINESLRLVNQLSNALKNGSSGTAEATKLLDQLSKLDSSLSSFRDYVKKDLNSSLVSISQRIMDELNKGQTALSNVQSKLNTIDQVINSGQAILKNGKTRIDRLQTVLPSIEQQYISAVKNAQANFPKVKSDVAKAANFVRNDLPQLEQRLTNATASVNKNLPTLLNGYDQAVGLLNKNQPQAKKALSDLADFSQNKLPDVEKDLKKANKIFKKLDKDDAVDKLIDTLKNDLKKQAGIIANPINKKTVDVFPVKDYGSGMTPFYTALSVWVGALLMVSLLTVDNKHKSLESVLTTRQVFLGKAGFFIMLGMLQALIVSVGDLLILKAGVESPVLFVLITIFCSIIFNSIVYTCVSLLGNPGKAIAIVLLVLQIAGGGGTFPIQTTPQFFQNISPYLPFTYAIDSLRETVGGIVPEILITKLIILTLFGIGFFVVGLILKPVTDPLMKRVSEKVDQSNVTE

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications