PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 06-JUL-2013

⊟Summary

• organism: Staphylococcus aureus Newman
• locus tag: NWMN_2411 [new locus tag: NWMN_RS13865 ]
• pan locus tag^?: SAUPAN006149000
• symbol: NWMN_2411
• pan gene symbol^?: —
• synonym:
• product: transcriptional regulator MarR family protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: NWMN_2411 [new locus tag: NWMN_RS13865 ]
• symbol: NWMN_2411
• product: transcriptional regulator MarR family protein
• replicon: chromosome
• strand: -
• coordinates: 2654593..2655051
• length: 459
• essential: unknown other strains

⊟Accession numbers

• Gene ID: 5331485 NCBI
• RefSeq: YP_001333445 NCBI
• BioCyc:
• MicrobesOnline: 3708013 MicrobesOnline

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

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  ATGAAGAGAGAAGTTATTTTAAAATTACAACAATTTATTATAGAAAGAGAAAATGCCGAT
  AAAAGAAGACAGTATAAAAAGGAAAATGAGGAACTAGATTTATCTCTAACACAATTTCAT
  ATCATAGAGTTGATTGATAATAATGATAAAGTGAATAATAAATTTTTGTCTGAAATGTTA
  AATGTATCAAAACCAGCAATTACTAAATCGATAAAAAAACTTTTAGCGAAAGACTTAGTA
  GTTGAATCGCACAATGAATTTAACAAAAGAGAAGTTAATTATTCATTAACACAAAAAGGA
  AAAAAATTATCTTATATACATGATGAATTACATGAAAAATCGGTAAAAAAATATGAAGAG
  GTACTTAAAGTCTTTGATGATGATGAAATGGCAGTTATTATAGAGTTTTTAAACCGTAGT
  ATAGAAGAATTAAAAAAAGAAGATGGTTTAAATGATTAA
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⊟Protein

⊟General

• locus tag: NWMN_2411 [new locus tag: NWMN_RS13865 ]
• symbol: NWMN_2411
• description: transcriptional regulator MarR family protein
• length: 152
• theoretical pI: 6.15058
• theoretical MW: 18079.6
• GRAVY: -0.765789

⊟Function

• TIGRFAM:
  homoprotocatechuate degradation operon regulator, HpaR (TIGR02337; HMM-score: 39.9)
  and 7 more
  Signal transduction Regulatory functions DNA interactions staphylococcal accessory regulator family (TIGR01889; HMM-score: 20.5)
  mobile rSAM pair MarR family regulator (TIGR04472; HMM-score: 20.5)
  EPS-associated transcriptional regulator, MarR family (TIGR04176; HMM-score: 17.2)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 16.5)
  Signal transduction Regulatory functions DNA interactions iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 16.5)
  Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 15.2)
  Signal transduction Regulatory functions DNA interactions transcriptional regulator, Acidobacterial, PadR-family (TIGR03433; HMM-score: 14.7)
• TheSEED: data available for COL, NCTC8325, USA300_FPR3757
• PFAM:
  HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 47.4)
  and 15 more
  HTH_27; Winged helix DNA-binding domain (PF13463; HMM-score: 37.8)
  MarR_2; MarR family (PF12802; HMM-score: 33.2)
  HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 29.9)
  Fe_dep_repress; Iron dependent repressor, N-terminal DNA binding domain (PF01325; HMM-score: 26.3)
  HxlR; HxlR-like helix-turn-helix (PF01638; HMM-score: 24.8)
  HTH_11; HTH domain (PF08279; HMM-score: 24.7)
  HTH_34; Winged helix DNA-binding domain (PF13601; HMM-score: 22.1)
  HTH_45; Winged helix-turn-helix (PF14947; HMM-score: 18.8)
  TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 16.6)
  no clan defined Phage_rep_O; Bacteriophage replication protein O (PF04492; HMM-score: 14.8)
  Pep3_Vps18; Pep3/Vps18/deep orange family (PF05131; HMM-score: 14.5)
  TINF2_N; TERF1-interacting nuclear factor 2 N-terminus (PF14973; HMM-score: 14.4)
  HTH (CL0123) GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 13.2)
  HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 12.9)
  no clan defined SieB; Super-infection exclusion protein B (PF14163; HMM-score: 9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular possibility: 1
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: 1
  • Predicted Cleavage Site: No CleavageSite
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.006685
  • TAT(Tat/SPI): 0.000219
  • LIPO(Sec/SPII): 0.00043
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 151222623 NCBI
• RefSeq: YP_001333445 NCBI
• UniProt: A0A0H3KIV1 UniProt

⊟Protein sequence

• MKREVILKLQQFIIERENADKRRQYKKENEELDLSLTQFHIIELIDNNDKVNNKFLSEMLNVSKPAITKSIKKLLAKDLVVESHNEFNKREVNYSLTQKGKKLSYIHDELHEKSVKKYEEVLKVFDDDEMAVIIEFLNRSIEELKKEDGLND

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: NWMN_2410 < NWMN_2411

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications