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NCBI: 10-JUN-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus COL
- locus tag: SACOL2524 [new locus tag: SACOL_RS13220 ]
- pan locus tag?: SAUPAN006149000
- symbol: SACOL2524
- pan gene symbol?: —
- synonym:
- product: MarR family transcriptional regulator
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SACOL2524 [new locus tag: SACOL_RS13220 ]
- symbol: SACOL2524
- product: MarR family transcriptional regulator
- replicon: chromosome
- strand: -
- coordinates: 2585246..2585710
- length: 465
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3238188 NCBI
- RefSeq: YP_187318 NCBI
- BioCyc: see SACOL_RS13220
- MicrobesOnline: 913996 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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421GTGGATATGAAGAGAGAAGTTATTTTAAAATTACAACAATTTATTATAGAAAGAGAAAAT
GCCGATAAAAGAAGACAGTATAAAAAGGAAAATGAGGAACTAGATTTATCTCTAACACAA
TTTCATATCATAGAGTTGATTGATAATAATGATAAAGTGAATAATAAATTTTTGTCTGAA
ATGTTAAATGTATCAAAACCAGCAATTACTAAATCGATAAAAAAACTTTTAGCGAAAGAC
TTAGTAGTTGAATCGCACAATGAATTTAACAAAAGAGAAGTTAATTATTCATTAACACAA
AAAGGAAAAAAATTATCTTATATACATGATGAATTACATGAAAAATCGGTAAAAAAATAT
GAAGAGGTACTTAAAGTCTTTGATGATGATGAAATGGCAGTTATTATAGAGTTTTTAAAC
CGTAGTATAGAAGAATTAAAAAAAGAAGATGGTTTAAATGATTAA60
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465
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SACOL2524 [new locus tag: SACOL_RS13220 ]
- symbol: SACOL2524
- description: MarR family transcriptional regulator
- length: 154
- theoretical pI: 5.75246
- theoretical MW: 18325.9
- GRAVY: -0.766234
⊟Function[edit | edit source]
- TIGRFAM: homoprotocatechuate degradation operon regulator, HpaR (TIGR02337; HMM-score: 39.9)and 7 moremobile rSAM pair MarR family regulator (TIGR04472; HMM-score: 20.6)Regulatory functions DNA interactions staphylococcal accessory regulator family (TIGR01889; HMM-score: 20.3)EPS-associated transcriptional regulator, MarR family (TIGR04176; HMM-score: 17)Biosynthesis of cofactors, prosthetic groups, and carriers Other iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 16.5)Regulatory functions DNA interactions iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 16.5)Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 15.2)Regulatory functions DNA interactions transcriptional regulator, Acidobacterial, PadR-family (TIGR03433; HMM-score: 14.7)
- TheSEED :
- Transcriptional regulator, MarR family
- PFAM: HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 47.4)and 15 moreHTH_27; Winged helix DNA-binding domain (PF13463; HMM-score: 37.8)MarR_2; MarR family (PF12802; HMM-score: 33.1)HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 29.8)Fe_dep_repress; Iron dependent repressor, N-terminal DNA binding domain (PF01325; HMM-score: 26.5)HxlR; HxlR-like helix-turn-helix (PF01638; HMM-score: 24.8)HTH_11; HTH domain (PF08279; HMM-score: 24.7)HTH_34; Winged helix DNA-binding domain (PF13601; HMM-score: 22.1)HTH_45; Winged helix-turn-helix (PF14947; HMM-score: 18.7)TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 16.5)no clan defined Phage_rep_O; Bacteriophage replication protein O (PF04492; HMM-score: 14.7)Pep3_Vps18; Pep3/Vps18/deep orange family (PF05131; HMM-score: 14.4)TINF2_N; TERF1-interacting nuclear factor 2 N-terminus (PF14973; HMM-score: 14.3)HTH (CL0123) GntR; Bacterial regulatory proteins, gntR family (PF00392; HMM-score: 13.2)HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 12.8)no clan defined SieB; Super-infection exclusion protein B (PF14163; HMM-score: 9.1)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- LocateP: Intracellular
- Prediction by SwissProt Classification: Cytoplasmic
- Pathway Prediction: No pathway
- Intracellular possibility: 1
- Signal peptide possibility: -1
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.005778
- TAT(Tat/SPI): 0.000262
- LIPO(Sec/SPII): 0.000426
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MDMKREVILKLQQFIIERENADKRRQYKKENEELDLSLTQFHIIELIDNNDKVNNKFLSEMLNVSKPAITKSIKKLLAKDLVVESHNEFNKREVNYSLTQKGKKLSYIHDELHEKSVKKYEEVLKVFDDDEMAVIIEFLNRSIEELKKEDGLND
⊟Experimental data[edit | edit source]
- experimentally validated: PeptideAtlas
- protein localization: Cytoplasmic [1]
- quantitative data / protein copy number per cell:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
The Staphylococcus aureus proteome.
Int J Med Microbiol: 2014, 304(2);110-20
[PubMed:24439828] [WorldCat.org] [DOI] (I p)