PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus Newman
• locus tag: NWMN_RS11130 [old locus tag: NWMN_1929 ]
• pan locus tag^?: SAUPAN005193000
• symbol: NWMN_RS11130
• pan gene symbol^?: —
• synonym:
• product: succinyl-diaminopimelate desuccinylase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: NWMN_RS11130 [old locus tag: NWMN_1929 ]
• symbol: NWMN_RS11130
• product: succinyl-diaminopimelate desuccinylase
• replicon: chromosome
• strand: +
• coordinates: 2135868..2137091
• length: 1224
• essential: unknown other strains

⊟Accession numbers

• Location: NC_009641 (2135868..2137091) NCBI
• BioCyc:
• MicrobesOnline: see NWMN_1929

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  ATGACAACTTTTAGTGAAAAAGAAAAAATTCAATTACTAGCAGATATTGTTGAACTACAA
  ACTGAAAATAATAATGAAATAGACGTTTGTAATTATTTAACAGATTTATTCGACAAGTAC
  GATATTAAATCTGAAATTTTGAAAGTTAATGAACACCGCGCCAATATCGTTGCAGAAATC
  GGTAACGGCTCACCTATACTCGCATTGAGTGGTCATATGGATGTTGTTGATGCAGGAAAT
  CAAGATAATTGGTCATATCCCCCTTTTCAACTGACAGAAAAAGATGGCAAATTATATGGC
  CGAGGCACTACAGATATGAAAGGCGGTTTAATGGCTTTGGTCGTATCTCTAATCGAATTA
  AAAGAACAAAATGAATTGCCTCATGGAACGATTAGATTACTGGCTACTGCTGGCGAAGAG
  AAAGAACAAGAAGGTGCCAAATTATTAGCTGATAAAGGCTATTTAGACGATGTCGATGGC
  TTAATTATTGCTGAACCAACTGGATCTGGAATTTATTATGCACATAAGGGGTCTATGTCA
  TGTAAAGTAACTGCAACTGGTAAAGCTGTCCATAGCTCAGTTCCATTTATTGGTGACAAT
  GCAATTGATACACTGCTTGAATTTTATAATCTATTTAAAGAAAAATATTCAGAGCTTAAA
  CAACAAGATACTAAACATGAATTAGATGTTGCGCCTATGTTCAAATCATTGATTGGAAAA
  GAAATTTCTGAAGAGGATGCAAATTATGCATCTGGTCTTACAGCTGTATGTTCGATTATA
  AATGGCGGCAAACAATTTAACTCTGTACCAGATGAAGCTTCACTTGAATTTAACGTAAGA
  CCAGTTCCTGAGTATGATAACGACTTTATAGAATCGTTTTTCCAAAATATCATTAATGAT
  GTGGATAGCAATAAGCTTTCACTCGATATTCCAAGCAATCACCGACCTGTAACAAGCGAT
  AAAAATAGCAAATTAATTACTACGATTAAAGATGTAGCTTCTAGTTATGTAGAACAAGAC
  GAAATATTTGTTTCAGCGCTTGTAGGTGCAACAGATGCCTCTAGTTTCTTAGGAGATAAT
  AAGGACAATGTTGATTTAGCCATTTTTGGACCAGGTAATCCATTAATGGCACATCAAATC
  GATGAATATATTGAAAAAGATATGTATCTGAAATATATTGATATTTTTAAAGAGGCTTCC
  ATTCAATATTTAAAAGAAAAATAA
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⊟Protein

⊟General

• locus tag: NWMN_RS11130 [old locus tag: NWMN_1929 ]
• symbol: NWMN_RS11130
• description: succinyl-diaminopimelate desuccinylase
• length: 407
• theoretical pI: 4.27856
• theoretical MW: 45097.3
• GRAVY: -0.329975

⊟Function

• TIGRFAM:
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides peptidase, ArgE/DapE family (TIGR01910; EC 3.4.-.-; HMM-score: 300.7)
  and 11 more
  Metabolism Amino acid biosynthesis Glutamate family acetylornithine deacetylase (ArgE) (TIGR01892; EC 3.5.1.16; HMM-score: 167.9)
  Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01246; EC 3.5.1.18; HMM-score: 134.5)
  Metabolism Amino acid biosynthesis Aspartate family succinyl-diaminopimelate desuccinylase (TIGR01900; EC 3.5.1.18; HMM-score: 122)
  putative selenium metabolism hydrolase (TIGR03526; HMM-score: 114.6)
  N-acetyl-ornithine/N-acetyl-lysine deacetylase (TIGR01902; HMM-score: 100.7)
  putative dipeptidase (TIGR01887; EC 3.4.13.-; HMM-score: 95.3)
  N-acyl-L-amino-acid amidohydrolase (TIGR01880; EC 3.5.1.14; HMM-score: 78.3)
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides amidohydrolase (TIGR01891; HMM-score: 75.6)
  Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides dipeptidase PepV (TIGR01886; EC 3.4.13.-; HMM-score: 51.8)
  peptidase T-like protein (TIGR01883; HMM-score: 31.3)
  Xaa-His dipeptidase (TIGR01893; EC 3.4.13.20; HMM-score: 29.2)
• TheSEED: data available for N315, NCTC8325, USA300_FPR3757
• PFAM:
  Peptidase_MH (CL0035) Peptidase_M20; Peptidase family M20/M25/M40 (PF01546; HMM-score: 137.5)
  and 2 more
  no clan defined M20_dimer; Peptidase dimerisation domain (PF07687; HMM-score: 81.4)
  Peptidase_MH (CL0035) Peptidase_M28; Peptidase family M28 (PF04389; HMM-score: 21.6)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.003302
  • TAT(Tat/SPI): 0.000133
  • LIPO(Sec/SPII): 0.000511
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446128783 NCBI
• RefSeq: WP_000206638 NCBI
• UniProt: see NWMN_1929

⊟Protein sequence

• MTTFSEKEKIQLLADIVELQTENNNEIDVCNYLTDLFDKYDIKSEILKVNEHRANIVAEIGNGSPILALSGHMDVVDAGNQDNWSYPPFQLTEKDGKLYGRGTTDMKGGLMALVVSLIELKEQNELPHGTIRLLATAGEEKEQEGAKLLADKGYLDDVDGLIIAEPTGSGIYYAHKGSMSCKVTATGKAVHSSVPFIGDNAIDTLLEFYNLFKEKYSELKQQDTKHELDVAPMFKSLIGKEISEEDANYASGLTAVCSIINGGKQFNSVPDEASLEFNVRPVPEYDNDFIESFFQNIINDVDSNKLSLDIPSNHRPVTSDKNSKLITTIKDVASSYVEQDEIFVSALVGATDASSFLGDNKDNVDLAIFGPGNPLMAHQIDEYIEKDMYLKYIDIFKEASIQYLKEK

⊟Experimental data

• experimentally validated: data available for NCTC8325
• protein localization:
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator: SigB see NWMN_1929

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications