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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS12135 [old locus tag: NWMN_2097 ]
  • pan locus tag?: SAUPAN005589000
  • symbol: NWMN_RS12135
  • pan gene symbol?: lacC
  • synonym:
  • product: tagatose-6-phosphate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_RS12135 [old locus tag: NWMN_2097 ]
  • symbol: NWMN_RS12135
  • product: tagatose-6-phosphate kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 2335351..2336283
  • length: 933
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_009641 (2335351..2336283) NCBI
  • BioCyc:
  • MicrobesOnline: see NWMN_2097

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGATTTTAACTTTAACATTAAATCCATCCGTTGATATTTCATACCCATTAACAGCATTG
    AAATTAGATGATGTTAATCGTGTTCAAGAAGTAAGTAAAACAGCTGGTGGTAAAGGTTTA
    AATGTAACAAGAGTACTTGCGCAAGTAGGTGAGCCAGTCCTTGCGAGTGGTTTTATTGGC
    GGTGAATTAGGTCAATTTATTGCTAAAAAATTAGATCATGCCGACATCAAGCATGCATTT
    TATAACATTAAGGGTGAAACACGAAACTGCATTGCAATTTTACATGAAGGGCAACAAACA
    GAAATTTTAGAGCAGGGACCGGAGATTGATAATCAAGAGGCTGCAGGATTTATTAAACAT
    TTTGAACAATTATTAGAAAAAGTTGAAGCAGTTGCTATTTCAGGTAGCTTACCTAAAGGA
    TTAAATCAAGATTATTATGCACAAATCATTGAACGATGCCAAAACAAAGGTGTGCCTGTG
    ATATTAGATTGCTCGGGTGCAACTTTGCAAACAGTTTTGGAAAATCCATACAAACCTACA
    GTCATTAAACCAAACATTTCTGAACTATATCAATTGCTTAACCAGCCACTTGATGAAAGT
    TTAGAAAGTTTGAAACAGGCAGTGTCACAACCCTTATTCGAAGGGATTGAGTGGATTATT
    GTGTCTTTAGGTGCACAAGGTGCATTCGCTAAGCACAATCATACATTCTATAGAGTGAAT
    ATTCCGACAATAAGTGTATTAAATCCGGTTGGTTCAGGTGATTCTACAGTTGCTGGAATT
    ACTTCAGCAATTCTTAATCATGAAAACGACCACGATTTACTAAAAAAAGCCAATACTTTA
    GGCATGCTGAATGCACAAGAAGCACAAACAGGTTATGTCAATTTAAATAATTATGATGAT
    TTATTCAATCAAATTGAAGTTTTAGAGGTGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    933

⊟Protein[edit | edit source]

Protein Data Bank: 2Q5R
Protein Data Bank: 2JG1
Protein Data Bank: 2JGV

⊟General[edit | edit source]

  • locus tag: NWMN_RS12135 [old locus tag: NWMN_2097 ]
  • symbol: NWMN_RS12135
  • description: tagatose-6-phosphate kinase
  • length: 310
  • theoretical pI: 4.66037
  • theoretical MW: 33853.2
  • GRAVY: -0.0977419

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.144?  ExPASy
    Tagatose-6-phosphate kinase ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate
  • TIGRFAM:
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides tagatose-6-phosphate kinase (TIGR01231; EC 2.7.1.144; HMM-score: 620.2)
    and 6 more
    hexose kinase, 1-phosphofructokinase family (TIGR03168; EC 2.7.1.-; HMM-score: 323.1)
    1-phosphofructokinase (TIGR03828; EC 2.7.1.56; HMM-score: 278.5)
    Metabolism Energy metabolism Sugars ribokinase (TIGR02152; EC 2.7.1.15; HMM-score: 64.5)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides bifunctional protein RfaE, domain I (TIGR02198; EC 2.7.1.-; HMM-score: 59.3)
    Metabolism Energy metabolism Sugars 5-dehydro-2-deoxygluconokinase (TIGR04382; EC 2.7.1.92; HMM-score: 47.7)
    Unknown function General YjeF family C-terminal domain (TIGR00196; HMM-score: 41.5)
  • TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
  • PFAM:
    Ribokinase (CL0118) PfkB; pfkB family carbohydrate kinase (PF00294; HMM-score: 217.5)
    and 2 more
    Carb_kinase; Carbohydrate kinase (PF01256; HMM-score: 40)
    Phos_pyr_kin; Phosphomethylpyrimidine kinase (PF08543; HMM-score: 19.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.013235
    • TAT(Tat/SPI): 0.000863
    • LIPO(Sec/SPII): 0.000994
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MILTLTLNPSVDISYPLTALKLDDVNRVQEVSKTAGGKGLNVTRVLAQVGEPVLASGFIGGELGQFIAKKLDHADIKHAFYNIKGETRNCIAILHEGQQTEILEQGPEIDNQEAAGFIKHFEQLLEKVEAVAISGSLPKGLNQDYYAQIIERCQNKGVPVILDCSGATLQTVLENPYKPTVIKPNISELYQLLNQPLDESLESLKQAVSQPLFEGIEWIIVSLGAQGAFAKHNHTFYRVNIPTISVLNPVGSGDSTVAGITSAILNHENDHDLLKKANTLGMLNAQEAQTGYVNLNNYDDLFNQIEVLEV

⊟Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • data available for N315

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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