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NCBI: 26-AUG-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA1253 [new locus tag: SA_RS07105 ]
  • pan locus tag?: SAUPAN003849000
  • symbol: ctpA
  • pan gene symbol?: ctpA
  • synonym:
  • product: carboxy-terminal processing proteinase ctpA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA1253 [new locus tag: SA_RS07105 ]
  • symbol: ctpA
  • product: carboxy-terminal processing proteinase ctpA
  • replicon: chromosome
  • strand: -
  • coordinates: 1427597..1429087
  • length: 1491
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGGATGATAAGCAACACACATCTTCATCCGATGATGAACGCGCTGAAATTGCAACAAGC
    AATCAAGACCAAGAAACTAATTCATCGAAACGCGTTCACTTAAAACGTTGGCAATTCATA
    TCAATATTAATTGGCACAACCCTAATAACAGCTGTCATCACAGTTGTTGCATATATTTTT
    ATAAATCAAAAAATAAGTGGTTTAAACAAAACTGATCAAGCAAACTTAAATAAAATTGAA
    AATGTGTATAAAATCTTAAATAGTGATTATTACAAAAAACAGGACTCTGACAAGTTAAGT
    AAAGCTGCAATTGATGGTATGGTCAAAGAATTAAAAGATCCTTATTCTGAATATTTAACA
    AAAGAACAAACGAAATCCTTTAATGAAGGTGTTTCAGGTGATTTTGTAGGTATTGGTGCA
    GAAATGCAAAAGAAAAATGATCAAATTATGGTTACTAGCCCTATGAAGGGTTCTCCAGCA
    GAACGTGCTGGCATCCGTCCTAAAGATGTCATTACTAAAGTAAATGGAAAATCAATTAAA
    GGAAAAGCATTAGACGAAGTTGTCAAAGACGTTCGTGGTAAAGAAAACACTGAAGTAACT
    TTAACTGTTCAACGAGGCAGTGAAGAAAAAGACGTTAAGATTAAACGTGAAAAAATTCAT
    GTTAAAAGTGTTGATTATAAGAAAAAAGGTAAGGTTGGAGTTATTACTATTAATAAATTC
    CAGAATGATACATCAGGTGAATTGAAAGATGCAGTTCTTAAAGCTCACAAAGATGGTTTG
    AAAAAGATTGTTTTAGATTTAAGAAATAATCCTGGTGGACTACTAGATGAAGCTGTTAAA
    ATGGCAAATATTTTTATCGATAAAGGAAAAACTGTTGTTAAACTAGAAAAAGGTAAAGAT
    ACTGAAGCAATTCAAACTTCTAATGACTCGTTAAAAGAAGCGAAAGACATGGATATATCC
    ATCTTAGTGAATGAAGGTTCAGCTAGTGCTTCTGAAGTGTTTACTGGTGCGCTAAAGGAC
    TATAATAAAGCTAAAGTTTATGGGTCAAAAACATTCGGCAAAGGTGTCGTACAAACTACA
    AGAGAGTTTAAGGATGGTTCATTGTTAAAATATACTGAAATGAAATGGTTAACGCCAGAT
    GGTCATTATATTCACGGTAAGGGCATTAAACCAGACGTTACTATTGACACACCTAAATAT
    CAATCTTTAAATGTCATTCCTAATACGAAAACATTTAAAGTTGGAGACGATGATAAAAAT
    ATTAAAACTATTAAAATTGGTTTATCAGCTTTAGGTTATAAAGTTGATAATGAATCAACG
    CAATTTGATCAAGCTTTAGAAAATCAAGTTAAAGCTTTCCAACAAGCGAATAAACTCGAG
    GTAACTGGTGAATTTAATAAAGAAACGAATAATAAATTTACTGAGTTATTAGTTGAAAAA
    GCTAATAAACATGATGATGTTCTCGATAAGTTGATTAATATTTTAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1491

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA1253 [new locus tag: SA_RS07105 ]
  • symbol: CtpA
  • description: carboxy-terminal processing proteinase ctpA
  • length: 496
  • theoretical pI: 9.69936
  • theoretical MW: 55250.5
  • GRAVY: -0.649395

⊟Function[edit | edit source]

  • reaction:
    EC 3.4.21.-?  ExPASy
  • TIGRFAM:
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides C-terminal processing peptidase (TIGR00225; EC 3.4.21.-; HMM-score: 344)
    Genetic information processing Protein fate Protein modification and repair C-terminal processing peptidase (TIGR00225; EC 3.4.21.-; HMM-score: 344)
    and 8 more
    putative carboxyl-terminal-processing protease, deltaproteobacterial (TIGR03900; EC 3.4.21.-; HMM-score: 262.9)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides peptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 36.3)
    Genetic information processing Protein fate Protein folding and stabilization peptidase Do (TIGR02037; EC 3.4.21.-; HMM-score: 36.3)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides RIP metalloprotease RseP (TIGR00054; EC 3.4.24.-; HMM-score: 28.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides periplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 21.4)
    Signal transduction Regulatory functions Protein interactions periplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 21.4)
    Cellular processes Cellular processes Sporulation and germination spore cortex-lytic enzyme (TIGR02869; HMM-score: 18.9)
    Signal transduction Regulatory functions Protein interactions anti-anti-sigma factor (TIGR00377; HMM-score: 12)
  • TheSEED  :
    • Carboxyl-terminal protease (EC 3.4.21.102)
  • PFAM:
    ClpP_crotonase (CL0127) Peptidase_S41; Peptidase family S41 (PF03572; HMM-score: 165.3)
    and 7 more
    PDZ-like (CL0466) PDZ_2; PDZ domain (PF13180; HMM-score: 56.2)
    PDZ; PDZ domain (Also known as DHR or GLGF) (PF00595; HMM-score: 51.6)
    PGBD (CL0244) PG_binding_1; Putative peptidoglycan binding domain (PF01471; HMM-score: 46.6)
    PDZ-like (CL0466) Tricorn_PDZ; Tricorn protease PDZ domain (PF14685; HMM-score: 17)
    PGBD (CL0244) PG_binding_2; Putative peptidoglycan binding domain (PF08823; HMM-score: 15)
    C_Lectin (CL0056) Ly49; Ly49-like protein, N-terminal region (PF08391; HMM-score: 10.4)
    no clan defined DUF3394; Domain of unknown function (DUF3394) (PF11874; HMM-score: 9.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.17
    • Cytoplasmic Membrane Score: 9.51
    • Cellwall Score: 0.16
    • Extracellular Score: 0.15
    • Internal Helix: 1
  • LocateP: N-terminally anchored (No CS)
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 7
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003084
    • TAT(Tat/SPI): 0.000838
    • LIPO(Sec/SPII): 0.004964
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MDDKQHTSSSDDERAEIATSNQDQETNSSKRVHLKRWQFISILIGTTLITAVITVVAYIFINQKISGLNKTDQANLNKIENVYKILNSDYYKKQDSDKLSKAAIDGMVKELKDPYSEYLTKEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIKGKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVDYKKKGKVGVITINKFQNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKDTEAIQTSNDSLKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTTREFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKNIKTIKIGLSALGYKVDNESTQFDQALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEKANKHDDVLDKLINILK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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