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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003849000
- symbol?: ctpA
- synonym:
- description?: serine protease
- serine protease
- carboxyl-terminal protease
- S41 family peptidase
- carboxy-terminal processing proteinase ctpA
- putative carboxy-terminal processing proteinase
- carboxy-processing protease
- carboxy-terminal processing protease
- C-terminal processing peptidase family protein
- ctpA-like serine protease
- putative carboxy-terminal processing proteinasectpA
- putative CtpA-like serine protease
- putative protease
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4134288..4135783
- synteny block?: BlockID0029050
- occurrence?: in 100% of 34 strains
ctpA: carboxyl-terminus processing protease [1]
Staphylococcal proteins may require processing at their C-terminus to function or C→N-terminal degradation for turnover. CtpA is the only C-terminal serine protease in staphylococci and is essential for virulence. It localizes to the cell wall and is sharply induced by serum proteins. Finally, it is essential for recovery from SosA protein-induced cell cycle arrest where it turns over the SosA protein. Native substrates of CtpA and triggers for CtpA-mediated C-terminal processing have not been well characterized. Additional protein maturation / processing functions have been proposed but not experimentally confirmed.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1374 (ctpA)
08BA02176:
C248_1460
11819-97:
MS7_1376
6850:
RSAU_001299 (ctpA)
71193:
ST398NM01_1421
ECT-R 2:
ECTR2_1276
ED133:
SAOV_1429c
ED98:
SAAV_1403
HO 5096 0412:
SAEMRSA15_12830
JH1:
SaurJH1_1509
JH9:
SaurJH9_1480
JKD6008:
SAA6008_01388
JKD6159:
SAA6159_01287
LGA251:
SARLGA251_13360
M013:
M013TW_1366
MRSA252:
SAR1432
MSHR1132:
SAMSHR1132_12620
MSSA476:
SAS1363
Mu3:
SAHV_1408 (ctpA)
Mu50:
SAV1420 (ctpA)
MW2:
MW1310 (ctpA)
RF122:
SAB1275c
ST398:
SAPIG1421
T0131:
SAT0131_01500
TCH60:
HMPREF0772_11787
TW20:
SATW20_14210
USA300_TCH1516:
USA300HOU_1357 (ctpA)
VC40:
SAVC_06350
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 | |
| JSNZ |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
COL MDDKQHTSSSDDERAEIATSNQDQETNSSKRVHLKRWQFISILIGTILITAVITVVAYIF
N315 MDDKQHTSSSDDERAEIATSNQDQETNSSKRVHLKRWQFISILIGTTLITAVITVVAYIF
NCTC8325 MDDKQHTSSSDDERAEIATSNQDQETNSSKRVHLKRWQFISILIGTILITAVITVVAYIF
Newman MDDKQHTSSSDDERAEIATSNQDQETNSSKRVHLKRWQFISILIGTILITAVITVVAYIF
USA300_FPR3757 MDDKQHTSSSDDERAEIATSNQDQETNSSKRVHLKRWQFISILIGTILITAVITVVAYIF
JSNZ MDDKQHTSSSDDERAEIATSNQDQETNSSKRVHLKRWQFISILIGTILITAVITVVAYIF
********************************************** *************
COL INQKISGLNKTDQSNLNKIENVYKILNSDYYKKQDSDKLSKAAIDGMVKELKDPYSEYLT
N315 INQKISGLNKTDQANLNKIENVYKILNSDYYKKQDSDKLSKAAIDGMVKELKDPYSEYLT
NCTC8325 INQKISGLNKTDQANLNKIENVYKILNSDYYKKQDSDKLSKAAIDGMVKELKDPYSEYLT
Newman INQKISGLNKTDQANLNKIENVYKILNSDYYKKQDSDKLSKAAIDGMVKELKDPYSEYLT
USA300_FPR3757 INQKISGLNKTDQANLNKIENVYKILNSDYYKKQDSDKLSKAAIDGMVKELKDPYSEYLT
JSNZ INQKISGLNKTDQANLNKIENVYKILNSDYYKKQDSDKLSKAAIDGMVKELKDPYSEYLT
*************:**********************************************
COL KEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIK
N315 KEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIK
NCTC8325 KEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIK
Newman KEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIK
USA300_FPR3757 KEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIK
JSNZ KEQTKSFNEGVSGDFVGIGAEMQKKNDQIMVTSPMKGSPAERAGIRPKDVITKVNGKSIK
************************************************************
COL GKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVEYKKKGKVGVITINKF
N315 GKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVDYKKKGKVGVITINKF
NCTC8325 GKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVEYKKKGKVGVITINKF
Newman GKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVEYKKKGKVGVITINKF
USA300_FPR3757 GKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVEYKKKGKVGVITINKF
JSNZ GKALDEVVKDVRGKENTEVTLTVQRGSEEKDVKIKREKIHVKSVEYKKKGKVGVITINKF
********************************************:***************
COL QNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKD
N315 QNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKD
NCTC8325 QNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKD
Newman QNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKD
USA300_FPR3757 QNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKD
JSNZ QNDTSGELKDAVLKAHKDGLKKIVLDLRNNPGGLLDEAVKMANIFIDKGKTVVKLEKGKD
************************************************************
COL TEAIQTSNDALKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTT
N315 TEAIQTSNDSLKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTT
NCTC8325 TEAIQTSNDALKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTT
Newman TEAIQTSNDALKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTT
USA300_FPR3757 TEAIQTSNDALKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTT
JSNZ TEAIQTSNDALKEAKDMDISILVNEGSASASEVFTGALKDYNKAKVYGSKTFGKGVVQTT
*********:**************************************************
COL REFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKN
N315 REFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKN
NCTC8325 REFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKN
Newman REFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKN
USA300_FPR3757 REFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKN
JSNZ REFKDGSLLKYTEMKWLTPDGHYIHGKGIKPDVTIDTPKYQSLNVIPNTKTFKVGDDDKN
************************************************************
COL IKTIKIGLSALGYKVDNESTQFDKALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEK
N315 IKTIKIGLSALGYKVDNESTQFDQALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEK
NCTC8325 IKTIKIGLSALGYKVDNESTQFDKALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEK
Newman IKTIKIGLSALGYKVDNESTQFDKALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEK
USA300_FPR3757 IKTIKIGLSALGYKVDNESTQFDKALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEK
JSNZ IKTIKIGLSALGYKVDNETTQFDQALENQVKAFQQANKLEVTGEFNKETNNKFTELLVEK
******************:****:************************************
COL ANKHDDVLDKLINILK
N315 ANKHDDVLDKLINILK
NCTC8325 ANKHDDVLDKLINILK
Newman ANKHDDVLDKLINILK
USA300_FPR3757 ANKHDDVLDKLINILK
JSNZ ANKHDDVLDKLINILK
****************
- ↑ Ronan K Carroll, Frances E Rivera, Courtney K Cavaco, Grant M Johnson, David Martin, Lindsey N Shaw
The lone S41 family C-terminal processing protease in Staphylococcus aureus is localized to the cell wall and contributes to virulence.
Microbiology (Reading): 2014, 160(Pt 8);1737-1748
[PubMed:24928312] [WorldCat.org] [DOI] (I p)Martin S Bojer, Katarzyna Wacnik, Peter Kjelgaard, Clement Gallay, Amy L Bottomley, Marianne T Cohn, Gunnar Lindahl, Dorte Frees, Jan-Willem Veening, Simon J Foster, Hanne Ingmer
SosA inhibits cell division in Staphylococcus aureus in response to DNA damage.
Mol Microbiol: 2019, 112(4);1116-1130
[PubMed:31290194] [WorldCat.org] [DOI] (I p)