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NCBI: 26-AUG-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus N315
- locus tag: SA2217 [new locus tag: SA_RS12730 ]
- pan locus tag?: SAUPAN005972000
- symbol: SA2217
- pan gene symbol?: —
- synonym:
- product: hypothetical protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SA2217 [new locus tag: SA_RS12730 ]
- symbol: SA2217
- product: hypothetical protein
- replicon: chromosome
- strand: -
- coordinates: 2488916..2490679
- length: 1764
- essential: no DEG other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 1125145 NCBI
- RefSeq: NP_375540 NCBI
- BioCyc: see SA_RS12730
- MicrobesOnline: 104566 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1741ATGAACAATCAGACAAATTGGATAAAGATACTCAGCGGATTTGCTTCTGATAGTAAATGG
AAAATTATGTTATCAATTTTGTTGTCTATCATCAGTGTCTTTTCTGGATTAGTTCCATAT
TGGGCAGTCTTTAAAATTATTTTAATGATGATTAACAATGCATATACGATTAATTCGATT
ATGGTTTATATCTTTATTGCTTTAATCACTTATATTTCACAAGTGTGTTGTTTTGGAGCG
TCAACGATGCTATCACATATTACGGCATATGAAATTTTATCTGAAATTCGTAAAAAATTA
GCTCAAAAATTAATGCGCCTCCCTTTAGGCGTAGTGGAATCTAAGAAAATAGGTGAATTA
AAAAATATATTTGTCGATAAGGTTGAAACAATAGAATTACCTTTAGCACATATGATTCCT
GAAGTTATAGGAAACTTACTTTTGTCAGCTGCTATCTTTTTATACATAATGCTCATTGAT
TGGCGTATGGCTAGTGCCTTATTAGTAACGATACCAATTTCAATTTTCGCTTTTAAAAAA
GTTATGTCTGGATTTAATGAGACATATGCTGAACAAATGAAATCAAATAATTATATGAAT
AGCGCGATTGTAGAGTTTATCGAAGGCATTGAAGTGATTAAAACATTTAATCAATCTCAA
AGTTCATATAAAAAATATAAAGATGCAGTAGATAATTATAAGATTCACACTTTGAATTGG
TTTAAAAATACATGGGGGTATATGAATTTAGGAGCTAGTGTATTACCTTCAACATTTTTA
GGGATTTTACCGGTCGGCATGTATTTGATATCTATCAACCAATTAAACTATGCGGAATTT
TTCCTATGCATCGTATTATCTTTAGGTGTAGTAGCACCGATTAAGAATTTTACTAATTAT
GTAAATCATTTAAAGTCTATACAATACGCATTAACTGAAGTGAATCAAATATTAAGTCTA
GAAGAGTTAGTATTGTCAACAAAATTTAAGAAGCCTCAACATTATGAAATTGCTTTTAAT
AATGTTGGATTTTCATATAACAAAGATAAGGACGATCTGGTCTTTAAGCATTTATCATTT
ACAGTACCAGAAAATAATTTCACAGCTATCGTCGGGGCTTCTGGTAGCGGTAAGTCAACC
ATTGCCAAGCTTATATCACGATACTGGGATGTGACTTCAGGTGAAATTACGATTGGCGGT
ATAAATATAAAAGATATTGAATCGAAACAACTTAACGATTTAGTTGGTTTTGTTGGACAA
GATAACTTTTTATTAAATCTTACTTTTAAAGAAAATATTAAACTTGGCAATCCAGAAGCT
ACGGATGAGGCAGTTGAAAAAGCTGCCAAGTTAGCACAATGTCATGAATTTATTGAAAAG
TTGCCAGATGGATATGATACGAATGTTGGTACAGTGGGAGATAAATTGTCTGGTGGTGAA
AAACAACGAGTCACTATTGCAAGAATGATATTAAAAGATGCGCCTATCATTGTATTAGAT
GAAGCGACTGCTTACGTTGATCCAGACAACGAACAAAAAATTCAAGAAGCATTAAATGTG
TTGACGCAGGATAAAACATTGATTGTTATTGCACATCGGTTATCTACGATTCAACATGCA
GATCAAATTATTGTTTTAGGTAAACAACAAATTTTAGAAAAAGGGTCACATCACTTATTG
CTAAAATTAAACGGTAATTATAAGAAAATGTGGGATACGCACATGCATACAAAAGATTGG
GGAATCAATACTGGACATAATTAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SA2217 [new locus tag: SA_RS12730 ]
- symbol: SA2217
- description: hypothetical protein
- length: 587
- theoretical pI: 7.71696
- theoretical MW: 66087.6
- GRAVY: 0.129642
⊟Function[edit | edit source]
- TIGRFAM: Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 341.1)Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 341.1)ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 310)thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 295.6)Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 281.6)and 72 moreProtein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 272.2)Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 271.4)Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 271.4)Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 271.4)Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 269)Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 269)Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 240.8)Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 240.8)Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 232.7)thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 218)Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 212.1)Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 212.1)Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 188)Transport and binding proteins Other multi drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 150.4)Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 133.6)Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 113.6)Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 113.6)Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 112.1)Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 102)Transport and binding proteins Anions cystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 97.2)Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 96.9)Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 94.8)Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 92.5)Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 92)Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 91.9)Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 85.6)Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 85.4)ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 83.4)Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 81.5)Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 81.5)Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 75.3)Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 74.1)gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 74)Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 73.8)proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 72.9)Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 71.4)ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 70.5)Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 68.7)lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 68.5)Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 68.1)Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 67.2)Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 67.2)Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 67)Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 66.9)phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 66.7)D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 64.3)Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 64.2)Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 64.1)Transport and binding proteins Carbohydrates, organic alcohols, and acids peroxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 62.5)Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 62.3)Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 62.3)Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 61.7)Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 61.7)Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 57)Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 57)2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 55.1)Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 54.9)Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 54.7)Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 54.4)ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 53.9)DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 44.2)Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 43.9)Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 43.4)Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 41)Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 40.1)Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 32.6)DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 32.6)Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 30.4)Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 26)DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 26)DNA metabolism DNA replication, recombination, and repair DNA repair protein RecN (TIGR00634; HMM-score: 12.3)Transcription RNA processing polynucleotide kinase-phosphatase (TIGR04075; HMM-score: 10.9)
- TheSEED :
- Heterodimeric efflux ABC transporter, permease/ATP-binding subunit 1
Respiration Electron accepting reactions Terminal cytochrome d ubiquinol oxidases Transport ATP-binding protein CydDand 1 more - PFAM: P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 105.6)ABC_membrane (CL0241) ABC_membrane; ABC transporter transmembrane region (PF00664; HMM-score: 89)and 20 moreP-loop_NTPase (CL0023) SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 41.7)AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 21.4)AAA_23; AAA domain (PF13476; HMM-score: 21.2)AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 20)AAA_15; AAA ATPase domain (PF13175; HMM-score: 17.8)DUF87; Domain of unknown function DUF87 (PF01935; HMM-score: 17.5)ABC_ATPase; Predicted ATPase of the ABC class (PF09818; HMM-score: 17.2)RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 15.9)AAA_18; AAA domain (PF13238; HMM-score: 15.6)NB-ARC; NB-ARC domain (PF00931; HMM-score: 15.2)AAA_22; AAA domain (PF13401; HMM-score: 15)AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 14.9)AAA_30; AAA domain (PF13604; HMM-score: 14.9)SbcCD_C; Putative exonuclease SbcCD, C subunit (PF13558; HMM-score: 13.3)AAA_16; AAA ATPase domain (PF13191; HMM-score: 13.2)AAA_10; AAA-like domain (PF12846; HMM-score: 11.9)no clan defined DUF3987; Protein of unknown function (DUF3987) (PF13148; HMM-score: 11.4)NADP_Rossmann (CL0063) Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 11.2)P-loop_NTPase (CL0023) AAA_25; AAA domain (PF13481; HMM-score: 11)no clan defined DUF4229; Protein of unknown function (DUF4229) (PF14012; HMM-score: 7.8)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 10
- Cellwall Score: 0
- Extracellular Score: 0
- Internal Helices: 4
- LocateP: Multi-transmembrane
- Prediction by SwissProt Classification: Membrane
- Pathway Prediction: Sec-(SPI)
- Intracellular possibility: 0.17
- Signal peptide possibility: -1
- N-terminally Anchored Score: -1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.001985
- TAT(Tat/SPI): 0.000136
- LIPO(Sec/SPII): 0.029055
- predicted transmembrane helices (TMHMM): 4
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MNNQTNWIKILSGFASDSKWKIMLSILLSIISVFSGLVPYWAVFKIILMMINNAYTINSIMVYIFIALITYISQVCCFGASTMLSHITAYEILSEIRKKLAQKLMRLPLGVVESKKIGELKNIFVDKVETIELPLAHMIPEVIGNLLLSAAIFLYIMLIDWRMASALLVTIPISIFAFKKVMSGFNETYAEQMKSNNYMNSAIVEFIEGIEVIKTFNQSQSSYKKYKDAVDNYKIHTLNWFKNTWGYMNLGASVLPSTFLGILPVGMYLISINQLNYAEFFLCIVLSLGVVAPIKNFTNYVNHLKSIQYALTEVNQILSLEELVLSTKFKKPQHYEIAFNNVGFSYNKDKDDLVFKHLSFTVPENNFTAIVGASGSGKSTIAKLISRYWDVTSGEITIGGINIKDIESKQLNDLVGFVGQDNFLLNLTFKENIKLGNPEATDEAVEKAAKLAQCHEFIEKLPDGYDTNVGTVGDKLSGGEKQRVTIARMILKDAPIIVLDEATAYVDPDNEQKIQEALNVLTQDKTLIVIAHRLSTIQHADQIIVLGKQQILEKGSHHLLLKLNGNYKKMWDTHMHTKDWGINTGHN
⊟Experimental data[edit | edit source]
- experimentally validated: data available for NCTC8325
- protein localization:
- quantitative data / protein copy number per cell:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Artem Cherkasov, Michael Hsing, Roya Zoraghi, Leonard J Foster, Raymond H See, Nikolay Stoynov, Jihong Jiang, Sukhbir Kaur, Tian Lian, Linda Jackson, Huansheng Gong, Rick Swayze, Emily Amandoron, Farhad Hormozdiari, Phuong Dao, Cenk Sahinalp, Osvaldo Santos-Filho, Peter Axerio-Cilies, Kendall Byler, William R McMaster, Robert C Brunham, B Brett Finlay, Neil E Reiner
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
J Proteome Res: 2011, 10(3);1139-50
[PubMed:21166474] [WorldCat.org] [DOI] (I p)