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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 26-AUG-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA2386 [new locus tag: SA_RS13660 ]
  • pan locus tag?: SAUPAN006288000
  • symbol: tnpC
  • pan gene symbol?: tnpC
  • synonym:
  • product: transposition regulatory protein tnpC

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA2386 [new locus tag: SA_RS13660 ]
  • symbol: tnpC
  • product: transposition regulatory protein tnpC
  • replicon: chromosome
  • strand: -
  • coordinates: 2674325..2674702
  • length: 378
  • essential: no DEG

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    ATGGATAAACAAGTTAGAAATACAACAGAAATTGTACGTTTGGCGAAGCAGAAATCAAAA
    AAGACAAGGGAAAAAGTAGACAAAGCGATTTCTAAATTTTCGATTGAAGGTAAAGTTATT
    AATTTTAATTCAATAGCAAAGGAAGCTAATGTTTCTAAATCATGGCTTTATAAGGAACAC
    GATATTAGGCAAAGAATCGAATCCCTTCGTGAGCGTCAAATAACAGCAAATGTAGTCTCA
    AAACCCAAGAAAAGTTCTCGTTCGGAGGAAATCCTTATTAAAACCTTAAAAAGAAGAGTA
    ATGGAATTAGAAAAAGAAAATAAAAAATTACAGAACCAAATTCAAAAATTATATGGAGAT
    CTGTATAATAAAGAATAA
    60
    120
    180
    240
    300
    360
    378

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA2386 [new locus tag: SA_RS13660 ]
  • symbol: TnpC
  • description: transposition regulatory protein tnpC
  • length: 125
  • theoretical pI: 10.822
  • theoretical MW: 14804.1
  • GRAVY: -1.0384

⊟Function[edit | edit source]

  • TIGRFAM:
    DNA 3'-phosphatase (TIGR01664; EC 3.1.3.32; HMM-score: 11.3)
  • TheSEED  :
    • Mobile element protein
  • PFAM:
    CoA-acyltrans (CL0149) Transferase; Transferase family (PF02458; HMM-score: 18.4)
    no clan defined HALZ; Homeobox associated leucine zipper (PF02183; HMM-score: 17.9)
    bZIP (CL0018) bZIP_2; Basic region leucine zipper (PF07716; HMM-score: 15.9)
    HTH (CL0123) LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 15.8)
    and 8 more
    Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 14.7)
    no clan defined SidE; Dot/Icm substrate protein (PF12252; HMM-score: 10.7)
    SlyX; SlyX (PF04102; HMM-score: 9.8)
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein (PF07926; HMM-score: 7.5)
    P-loop_NTPase (CL0023) AAA_11; AAA domain (PF13086; HMM-score: 7.4)
    no clan defined Herpes_BLRF2; Herpesvirus BLRF2 protein (PF05812; HMM-score: 7.1)
    FtsL (CL0225) DivIC; Septum formation initiator (PF04977; HMM-score: 6.6)
    no clan defined DUF4337; Domain of unknown function (DUF4337) (PF14235; HMM-score: 6.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007501
    • TAT(Tat/SPI): 0.000595
    • LIPO(Sec/SPII): 0.001342
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MDKQVRNTTEIVRLAKQKSKKTREKVDKAISKFSIEGKVINFNSIAKEANVSKSWLYKEHDIRQRIESLRERQITANVVSKPKKSSRSEEILIKTLKRRVMELEKENKKLQNQIQKLYGDLYNKE

⊟Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

T Ito, Y Katayama, K Hiramatsu
Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315.
Antimicrob Agents Chemother: 1999, 43(6);1449-58
[PubMed:10348769] [WorldCat.org] [DOI] (P p)

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