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NCBI: 10-JUN-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1125 [new locus tag: SACOL_RS05745 ]
  • pan locus tag?: SAUPAN003343000
  • symbol: ctaB
  • pan gene symbol?: ctaB
  • synonym:
  • product: protoheme IX farnesyltransferase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1125 [new locus tag: SACOL_RS05745 ]
  • symbol: ctaB
  • product: protoheme IX farnesyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 1137416..1138327
  • length: 912
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGAGCAAAGAGCATACTTTGTCACAAAATATTAGCAGAGTTAACTTCAAAGAATTGCAA
    CAGATAATTAAAATGGGACTTGTTCAAGGTAACTTAATTCCGGCTTTTGCGGGCGCATGG
    CTAGCAGTTGTAATGACAAATCATTCCTTCTTATCATCAATACCTCAAATTTTATTAATG
    CTATTTGGATCTACTTTAATTATGGGTGGCGCATGTGCGTTAAATAATTATTACGACCAA
    GATATTGATCGTATTATGCCTAGTAAACAAAATAGACCAACTGTAAATAATAGAATTACA
    GATCAAAATTTATTACTATTAAGTTTTGGTATGATGTTAGTTGGAGAAATTTGTTTGTTT
    TTATTGAATATACCATCAGGCGTACTTGGTCTTATGGGGATTGTAGGTTATGTGTCTTAT
    TACTCAATATGGTCTAAAAGACATACAACATGGAACACAGTGATTGGGAGTTTTCCTGGA
    GCAGTACCACCACTAATTGGATGGGTTGCAATTGAAGGACAAATTAGTTTAACAGCGATT
    GCGCTGTTTTTAGTTGTATTTTGTTGGCAACCAATTCATTTTTATGCCTTAGCTATTAAA
    CGTAAAGATGAATATGCACTTGCAAATATTCCAATGTTACCATCAGTTAAGGGCTTTAAA
    CGTACACGTGTCAGTATGTTTATCTGGTTGATTATTTTATTGCCAGTACCTTTATTACTA
    ATAAATTTAGGTGTCGTATTCGTAGTGTTAGCTACATTATTAAATTTAGGATGGATTGCA
    TTAGGTTTAACAACATTTAAGAAAAATTCAGATCAAACAAAATGGGCAACACAAATGTTT
    ATATATTCACTAAATTATTTAGTGATCTTTTTCGTGTTAGCTGTGATTGTTTCATTACTT
    ACTTTGATCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    912

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SACOL1125 [new locus tag: SACOL_RS05745 ]
  • symbol: CtaB
  • description: protoheme IX farnesyltransferase
  • length: 303
  • theoretical pI: 9.93909
  • theoretical MW: 33858.4
  • GRAVY: 0.735644

Function[edit | edit source]

  • reaction:
    EC 2.5.1.-?  ExPASy
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin protoheme IX farnesyltransferase (TIGR01473; EC 2.5.1.-; HMM-score: 318.5)
    and 2 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 4-hydroxybenzoate polyprenyl transferase (TIGR01474; EC 2.5.1.-; HMM-score: 62.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone putative 4-hydroxybenzoate polyprenyltransferase (TIGR01475; EC 2.5.1.-; HMM-score: 39.1)
  • TheSEED  :
    • Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB
    Respiration Respiration - no subcategory Biogenesis of cytochrome c oxidases  Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB
    and 1 more
    Stress Response Stress Response - no subcategory Flavohaemoglobin  Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB
  • PFAM:
    Terp_synthase (CL0613) UbiA; UbiA prenyltransferase family (PF01040; HMM-score: 189.5)
    and 3 more
    no clan defined TrbL; TrbL/VirB6 plasmid conjugal transfer protein (PF04610; HMM-score: 19)
    DUF4577; Domain of unknown function (DUF4577) (PF15145; HMM-score: 12.7)
    DUF3671; Protein of unknown function (PF12420; HMM-score: 7.5)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 9
  • LocateP: Multi-transmembrane(Lipid modified N-termini)
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPII)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: MGGACAL
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008034
    • TAT(Tat/SPI): 0.0009
    • LIPO(Sec/SPII): 0.002076
  • predicted transmembrane helices (TMHMM): 8

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MSKEHTLSQNISRVNFKELQQIIKMGLVQGNLIPAFAGAWLAVVMTNHSFLSSIPQILLMLFGSTLIMGGACALNNYYDQDIDRIMPSKQNRPTVNNRITDQNLLLLSFGMMLVGEICLFLLNIPSGVLGLMGIVGYVSYYSIWSKRHTTWNTVIGSFPGAVPPLIGWVAIEGQISLTAIALFLVVFCWQPIHFYALAIKRKDEYALANIPMLPSVKGFKRTRVSMFIWLIILLPVPLLLINLGVVFVVLATLLNLGWIALGLTTFKKNSDQTKWATQMFIYSLNYLVIFFVLAVIVSLLTLI

Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization: Integral membrane [1]
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

  1. Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)

Relevant publications[edit | edit source]