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NCBI: 10-JUN-2013
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus COL
- locus tag: SACOL1126 [new locus tag: SACOL_RS05750 ]
- pan locus tag?: SAUPAN003344000
- symbol: SACOL1126
- pan gene symbol?: ctaM
- synonym:
- product: hypothetical protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SACOL1126 [new locus tag: SACOL_RS05750 ]
- symbol: SACOL1126
- product: hypothetical protein
- replicon: chromosome
- strand: +
- coordinates: 1138352..1138813
- length: 462
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Gene ID: 3237825 NCBI
- RefSeq: YP_185990 NCBI
- BioCyc: see SACOL_RS05750
- MicrobesOnline: 912594 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
61
121
181
241
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361
421ATGGGCGTTCCAATTTTACCAACGATTAGTACGACATGTATTGTCATTAGTGCAATTTTA
ATTGCCATTGGTTGGAGACTTATTTGGAAAAGGGAAATAAATAAACACAAAAATGTTATG
TTAGCTGCAGCTGTTTTTGCTTTAACTTTTTTCTTAATCTATGCAAGTAGAACGATTTTT
ATCGGTAATACAGCATTTGGCGGACCAGCATCAATTAAGAAATATTATACGATTTTCTTA
TTTTTCCACATTAATTTAGCAACAATTGGTGGTATTCTAGGCCTAGTTCAAATTATTACT
GCATTTAAAGATAAATATAATGTACACCGCAAATTCGGGCCATTCGCTTCAGTTATATGG
TTCTGTACTGCAATTACAGGTGTAGCAGTTTACTTATTATTATATGTATTATATCCAGGT
GGAGAAACGACATCACTGATTAAAGCAACATTTGGTCATTAA60
120
180
240
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360
420
462
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SACOL1126 [new locus tag: SACOL_RS05750 ]
- symbol: SACOL1126
- description: hypothetical protein
- length: 153
- theoretical pI: 10.3728
- theoretical MW: 16909.2
- GRAVY: 0.870588
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED :
- Putative Heme biosynthesis related protein
- PFAM: no clan defined DUF420; Protein of unknown function (DUF420) (PF04238; HMM-score: 126.5)and 7 moreDUF2306; Predicted membrane protein (DUF2306) (PF10067; HMM-score: 34.8)DUF3488; Domain of unknown function (DUF3488) (PF11992; HMM-score: 13.7)DUF4750; Domain of unknown function (DUF4750) (PF15938; HMM-score: 11.7)TMCCDC2; Transmembrane and coiled-coil domain-containing protein 2 (PF15844; HMM-score: 11.5)Tetraspannin (CL0347) Tetraspannin; Tetraspanin family (PF00335; HMM-score: 9.4)no clan defined DHHC; DHHC palmitoyltransferase (PF01529; HMM-score: 9.4)DUF4131; Domain of unknown function (DUF4131) (PF13567; HMM-score: 7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 10
- Cellwall Score: 0
- Extracellular Score: 0
- Internal Helices: 4
- LocateP: Multi-transmembrane
- Prediction by SwissProt Classification: Membrane
- Pathway Prediction: Sec-(SPI)
- Intracellular possibility: 0.17
- Signal peptide possibility: -0.5
- N-terminally Anchored Score: 1
- Predicted Cleavage Site: No CleavageSite
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002487
- TAT(Tat/SPI): 0.000157
- LIPO(Sec/SPII): 0.004627
- predicted transmembrane helices (TMHMM): 4
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MGVPILPTISTTCIVISAILIAIGWRLIWKREINKHKNVMLAAAVFALTFFLIYASRTIFIGNTAFGGPASIKKYYTIFLFFHINLATIGGILGLVQIITAFKDKYNVHRKFGPFASVIWFCTAITGVAVYLLLYVLYPGGETTSLIKATFGH
⊟Experimental data[edit | edit source]
- experimentally validated: PeptideAtlas
- protein localization: Integral membrane [1] [2]
- quantitative data / protein copy number per cell:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: data available for NCTC8325
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
PLoS One: 2009, 4(12);e8176
[PubMed:19997597] [WorldCat.org] [DOI] (I e) - ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
The Staphylococcus aureus proteome.
Int J Med Microbiol: 2014, 304(2);110-20
[PubMed:24439828] [WorldCat.org] [DOI] (I p)
⊟Relevant publications[edit | edit source]
Neal D Hammer, Lici A Schurig-Briccio, Svetlana Y Gerdes, Robert B Gennis, Eric P Skaar
CtaM Is Required for Menaquinol Oxidase aa3 Function in Staphylococcus aureus.
mBio: 2016, 7(4);
[PubMed:27406563] [WorldCat.org] [DOI] (I e)