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NCBI: 10-JUN-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1178 [new locus tag: SACOL_RS06025 ]
  • pan locus tag?: SAUPAN003426000
  • symbol: SACOL1178
  • pan gene symbol?: ssl12
  • synonym:
  • product: superantigen-like protein

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1178 [new locus tag: SACOL_RS06025 ]
  • symbol: SACOL1178
  • product: superantigen-like protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1182590..1183306
  • length: 717
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAGTAAGAACATCACGAAAAATATAATTTTAACGACAACATTATTACTATTAGGTACT
    GTATTACCTCAAAATCAAAAACCAGTATTTAGTTTTTACTCTGAAGCTAAAGCTTATAGC
    ATTGGTCAAGATGAAACTAACATCAATGAATTAATTAAATATTACACACAGCCTCATTTT
    TCATTTTCAAATAAATGGCTATATCAATATGATAATGGAAACATTTATGTTGAACTTAAG
    AGATATTCATGGTCAGCACATATATCTTTATGGGGCGCTGAAAGTTGGGGAAATATTAAT
    CAGTTAAAAGATCGTTACGTAGATGTGTTTGGACTAAAAGACAAAGATACTGATCAGTTA
    TGGTGGTCTTATAGAGAGACATTTACAGGTGGCGTTACACCAGCCGCAAAACCTTCTGAT
    AAAACTTATAATCTTTTTGTGCAATACAAAGATAAACTACAAACGATTATTGGTGCGCAT
    AAAATATACCAAGGCAATAAACCAGTATTAACATTGAAAGAAATCGATTTCCGTGCACGA
    GAAGCGTTAATAAAAAATAAAATATTATATAACGAAAATCGTAATAAAGGTAAGCTTAAG
    ATCACCGGTGGCGGTAATAACTACACTATTGATTTAAGCAAAAGATTACATTCAGATCTA
    GCAAATGTTTATGTTAAAAATCCTAATAAAATAACTGTTGACGTCCTCTTTGATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    717

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SACOL1178 [new locus tag: SACOL_RS06025 ]
  • symbol: SACOL1178
  • description: superantigen-like protein
  • length: 238
  • theoretical pI: 9.83237
  • theoretical MW: 27568.1
  • GRAVY: -0.542857

Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • FIG01107944: hypothetical protein
  • PFAM:
    Ant-toxin_C (CL0386) Stap_Strp_tox_C; Staphylococcal/Streptococcal toxin, beta-grasp domain (PF02876; HMM-score: 21)
    OB_enterotoxin (CL0658) SSL_OB; Staphylococcal superantigen-like OB-fold domain (PF09199; HMM-score: 17.8)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.01
    • Extracellular Score: 9.97
    • Internal Helices: 0
  • LocateP: N-terminally anchored (No CS)
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: -0.17
    • Signal peptide possibility: 1
    • N-terminally Anchored Score: 5
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: Signal peptide SP(Sec/SPI) length 31 aa
    • SP(Sec/SPI): 0.809367
    • TAT(Tat/SPI): 0.009674
    • LIPO(Sec/SPII): 0.029593
    • Cleavage Site: CS pos: 31-32. VFS-FY. Pr: 0.3442
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MSKNITKNIILTTTLLLLGTVLPQNQKPVFSFYSEAKAYSIGQDETNINELIKYYTQPHFSFSNKWLYQYDNGNIYVELKRYSWSAHISLWGAESWGNINQLKDRYVDVFGLKDKDTDQLWWSYRETFTGGVTPAAKPSDKTYNLFVQYKDKLQTIIGAHKIYQGNKPVLTLKEIDFRAREALIKNKILYNENRNKGKLKITGGGNNYTIDLSKRLHSDLANVYVKNPNKITVDVLFD

Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]

Ilse Jongerius, Jörg Köhl, Manoj K Pandey, Maartje Ruyken, Kok P M van Kessel, Jos A G van Strijp, Suzan H M Rooijakkers
Staphylococcal complement evasion by various convertase-blocking molecules.
J Exp Med: 2007, 204(10);2461-71
[PubMed:17893203] [WorldCat.org] [DOI] (P p)