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NCBI: 10-JUN-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL1840 [new locus tag: SACOL_RS09440 ]
  • pan locus tag?: SAUPAN004507000
  • symbol: SACOL1840
  • pan gene symbol?:
  • synonym:
  • product: hypothetical protein

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SACOL1840 [new locus tag: SACOL_RS09440 ]
  • symbol: SACOL1840
  • product: hypothetical protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1895719..1896489
  • length: 771
  • essential: unknown other strains

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    TTGGGTTTTATCAAACGTAAACGAATGCCAATTGAATATTTTACGCATCAATTCGAAGAA
    ATTACATATTTGTCAGATGACTTACAAGTAAAAGCTTTAATGATGACACCACATCATGAA
    GTAAATCGCATTGTAGTTTATTTGCGAGGTGGCAAAGGTCAAGTAGGACGTGTGCGCGCA
    GGTAGATTAATGCAATTTTCAGATAGTCAAACTTTAGTGATTGGGCCATACTACCGAGGT
    AACAATGGGAGTGAAGGCAAAGACGAATTTTACCGTGGCGATTTAAATGATGTGACGCAA
    TTATTAAGGTTGCTACATGATAAATATCCACATGCATTTATCCACATGGTTGGTTTTTCG
    CGAGGTGGTTTACAAGGATTGTTGACATTTCAAGACTTACCAGTAACAAGTTATACAATC
    TGGGGTGGTGTCTCAGATATTGATTTAATGTATGAAGAACGTGTCGATTTAAGAGGCATG
    CTACGAAGAATGATTGGTCATCCGAAAAAAGATCGAGCGGCATATGAGGCACGCCAAGCG
    ATTCCAAACATTAATGAAAACAGTCCGCCAATATTAATTGTACATGGAGGGAAAGACCAG
    CAAGTTGGTATTCATCATGCGTATTATTTAGCGGACCAACTAGAGTTAAAAGGTGCCACG
    CATGAAACATTTTATCAAATGGCAGAAGGACATGTGCCAAGACCACCAGCGATGGTTGAA
    ACATTGACTTATATTAAAGAGTTTATGAACCAAGTTGAGTCGCATAGCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    771

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SACOL1840 [new locus tag: SACOL_RS09440 ]
  • symbol: SACOL1840
  • description: hypothetical protein
  • length: 256
  • theoretical pI: 7.52881
  • theoretical MW: 29379.4
  • GRAVY: -0.441797

Function[edit | edit source]

  • TIGRFAM:
  • TheSEED:  
    Dipeptidyl aminopeptidases/acylaminoacyl-peptidases
  • PFAM:
    AB_hydrolase (CL0028) Peptidase_S9; Prolyl oligopeptidase family (PF00326; HMM-score: 41.5)
    and 4 more
    Abhydrolase_1; alpha/beta hydrolase fold (PF00561; HMM-score: 19.8)
    NADP_Rossmann (CL0063) Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 18.1)
    AB_hydrolase (CL0028) Hydrolase_4; Serine aminopeptidase, S33 (PF12146; HMM-score: 15.3)
    Abhydrolase_6; Alpha/beta hydrolase family (PF12697; HMM-score: 13.7)

Structure, modifications & interactions[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001653
    • TAT(Tat/SPI): 0.000134
    • LIPO(Sec/SPII): 0.000206
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MGFIKRKRMPIEYFTHQFEEITYLSDDLQVKALMMTPHHEVNRIVVYLRGGKGQVGRVRAGRLMQFSDSQTLVIGPYYRGNNGSEGKDEFYRGDLNDVTQLLRLLHDKYPHAFIHMVGFSRGGLQGLLTFQDLPVTSYTIWGGVSDIDLMYEERVDLRGMLRRMIGHPKKDRAAYEARQAIPNINENSPPILIVHGGKDQQVGIHHAYYLADQLELKGATHETFYQMAEGHVPRPPAMVETLTYIKEFMNQVESHS

Experimental data[edit | edit source]

  • experimental localization: Cytoplasmic [1] [2]

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

  1. Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)
  2. Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

Relevant publications[edit | edit source]