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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL2458 [new locus tag: SACOL_RS12895 ]
  • pan locus tag?: SAUPAN006006000
  • symbol: SACOL2458
  • pan gene symbol?: aimA
  • synonym:
  • product: amino acid permease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL2458 [new locus tag: SACOL_RS12895 ]
  • symbol: SACOL2458
  • product: amino acid permease
  • replicon: chromosome
  • strand: +
  • coordinates: 2515017..2516654
  • length: 1638
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGAATAAAGACAAGCAATTGCACAACGACAAAATCAATCTATCCCAATTAGTCTTATTA
    GGGTTAGGCTCTTTAATAGGATCTGGTTGGCTATTTGGTGCGTGGGAAGCATCATCAATA
    GCTGGACCAGCAGCAATCATATCATGGGTTCTTGGATTCCTAGTCATTGGAACCATTGCC
    TATAACTACATTGAAATCGGCACAATGTTTCCTCAATCAGGTGGCATGAGTAACTATGCC
    CAGTATACACATGGCTCATTATTAGGCTTTATTGCTGCTTGGGCGAATTGGGTGTCTTTG
    GTGACAATAATACCTATCGAAGCTGTGTCAGCTGTTCAATATATGAGTTCTTGGCCGTGG
    CATTGGGCGAAACCAATGAGATATTTAATGGAAAATGGCTCTATTAGCACATACGGATTG
    CTAGCTGTATATCTCATCATTGTTATTTTTTCATTATTAAACTATTGGTCCGTAAAACTT
    TTAACATCATTTACGAGTTTAATTTCTGTATTTAAATTAGGCGTACCCATGTTAACCATC
    ATCATGTTGATGCTATCAGGATTCGACACTTCAAATTACGGCCATTCGGCAAGCACATTT
    ATGCCTTACGGAAGTGCACCGATTTTTGCTGCAACAACAGCATCAGGGATTATTTTTTCA
    TTCAATTCATTCCAGACAATTATTAATATGGGTTCAGAAATTAAAAATCCTGAAAAAAAT
    ATCGCAAGAGGCATCGCTATCTCACTGTCAATCAGTGCAGTGTTGTACATCATTTTACAA
    AGTACGTTTATCACTTCTATGCCTCAATCAATGTTACAACATAGTGGATGGAATGGCATC
    AACTTCAATTCACCATTTGCTGATTTAGCTATCTTATTAGGAATTAATTGGCTCGCAATT
    TTACTATACATTGAAGCTTTTGTATCACCATTCGGTACTGGCGTGTCATTTGTCGCCGTT
    ACAGGTCGAGTTTTACGAGCAATGGAGAAAAATGGACATATCCCTAAATTTCTTGGGAAG
    ATGAATGAAAAATATCATATCCCACGTGTAGCAATCATCTTTAATGCCATCATTAGTATG
    ATTATGGTTACATTATTTAGAGATTGGGGTACGCTAGCAGCAGTTATTTCTACTGCAACT
    TTAGTAGCCTATTTAACTGGCCCAACGACAGTGATTGCATTAAGAAAAATGGGACCAACA
    ATGACTCGTCCATTTAGAGCAAAAATTTTAAAAGTAATGGCACCATTATCATTTGTATTA
    GCTTCATTAGCTATATATTGGGCAATGTGGCCAACAACGGCTGAAGTTATTTTAATCATT
    ATACTTGGATTACCAATCTACTTCTTCTATGAATATCGTATGAATTGGCGTAATACAAAG
    AAACAAATTGGTGGTAGCTTATGGATTATTGTATATTTAATCGTGCTATCAATACTGTCA
    TTTATAGGAAGCAAAGAATTTAAAGGCTTAAATATGATTCACTATCCATTTGACTTTATC
    GTTATTATTATTGTGGCACTTATCTTCTATTACATCGGTACAACGAGTTCATTTGAAAGC
    GTCTATTTCCGTCGCGCAACACGAATCAATACGAAGATGCGTGAGTCACTAAATAATGAA
    TCAAAGTCATCTCATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1638

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL2458 [new locus tag: SACOL_RS12895 ]
  • symbol: SACOL2458
  • description: amino acid permease
  • length: 545
  • theoretical pI: 10.0252
  • theoretical MW: 60640.3
  • GRAVY: 0.604404

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid transporter (TIGR00909; HMM-score: 175.7)
    and 10 more
    Metabolism Transport and binding proteins Amino acids, peptides and amines cationic amino acid transport permease (TIGR00906; HMM-score: 98.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines L-type amino acid transporter (TIGR00911; HMM-score: 93.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines transporter, basic amino acid/polyamine antiporter (APA) family (TIGR00905; HMM-score: 91.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines ethanolamine permease (TIGR00908; HMM-score: 70.5)
    Metabolism Transport and binding proteins Amino acids, peptides and amines amino acid permease (yeast) (TIGR00913; HMM-score: 56.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines GABA permease (TIGR01773; HMM-score: 50.3)
    histidine-histamine antiporter (TIGR04298; HMM-score: 46.8)
    putrescine-ornithine antiporter (TIGR04299; HMM-score: 33.1)
    putative glutamate/gamma-aminobutyrate antiporter (TIGR03813; HMM-score: 31.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines arginine-ornithine antiporter (TIGR03810; HMM-score: 30.2)
  • TheSEED  :
    • Amino acid transporter
  • PFAM:
    APC (CL0062) AA_permease_2; Amino acid permease (PF13520; HMM-score: 145.8)
    and 2 more
    AA_permease; Amino acid permease (PF00324; HMM-score: 108.6)
    no clan defined Ac76; Orf76 (Ac76) (PF05814; HMM-score: 20.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 14
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -0.5
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.053846
    • TAT(Tat/SPI): 0.005643
    • LIPO(Sec/SPII): 0.055996
  • predicted transmembrane helices (TMHMM): 14

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNKDKQLHNDKINLSQLVLLGLGSLIGSGWLFGAWEASSIAGPAAIISWVLGFLVIGTIAYNYIEIGTMFPQSGGMSNYAQYTHGSLLGFIAAWANWVSLVTIIPIEAVSAVQYMSSWPWHWAKPMRYLMENGSISTYGLLAVYLIIVIFSLLNYWSVKLLTSFTSLISVFKLGVPMLTIIMLMLSGFDTSNYGHSASTFMPYGSAPIFAATTASGIIFSFNSFQTIINMGSEIKNPEKNIARGIAISLSISAVLYIILQSTFITSMPQSMLQHSGWNGINFNSPFADLAILLGINWLAILLYIEAFVSPFGTGVSFVAVTGRVLRAMEKNGHIPKFLGKMNEKYHIPRVAIIFNAIISMIMVTLFRDWGTLAAVISTATLVAYLTGPTTVIALRKMGPTMTRPFRAKILKVMAPLSFVLASLAIYWAMWPTTAEVILIIILGLPIYFFYEYRMNWRNTKKQIGGSLWIIVYLIVLSILSFIGSKEFKGLNMIHYPFDFIVIIIVALIFYYIGTTSSFESVYFRRATRINTKMRESLNNESKSSH

⊟Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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