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⊟Summary[edit | edit source]
- pan ID?: SAUPAN000860000
- symbol?: csa1A
- synonym:
- description?: tandem-type lipoprotein
- tandem-type lipoprotein
- staphylococcal tandem lipoprotein
- tandem lipoprotein
- putative lipoprotein
- staphylococcus tandem lipoproteins family protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1128174..1128945
- synteny block?: BlockID0004210
- occurrence?: in 58% of 33 strains
csa1A : tandem conserved staphylococcal antigen 1A [1]
• A crystal structure is available: 4BIH
• binds extracellular DNA as a lipoprotein during biofilm formation
• exact number of tandem repeats varies and can expand or contract over the course of an infection
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0096
08BA02176:
—
11819-97:
MS7_0089
6850:
RSAU_000050
71193:
—
ECT-R 2:
ECTR2_53
ED133:
—
ED98:
SAAV_0044
HO 5096 0412:
—
JH1:
SaurJH1_0087
JH9:
SaurJH9_0084
JKD6008:
—
JKD6159:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
SAMSHR1132_00720
MSSA476:
SAS0072
Mu3:
SAHV_0095
Mu50:
SAV0096
MW2:
MW0071
RF122:
—
ST398:
—
T0131:
—
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_0109
VC40:
SAVC_00230
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MMKRLNKLVLGIIFLFLVISITAGCGIGKEAEVKKSFEKTLSMYPIKNLEDLYDKEGYRD
N315 MMKRLNKLVLGIIFLFLVISITAGCGIGKEAEVKKSFEKTLSMYPIKNLEDLYDKEGYRD
NCTC8325 MMKRLNKLVLGIIFLFLVISITAGCGIGKEAEVKKSFEKTLSMYPIKNLEDLYDKEGYRD
Newman MMKRLNKLVLGIIFLFLVISITAGCGIGKEAEVKKSFEKTLSMYPIKNLEDLYDKEGYRD
USA300_FPR3757 MMKRLNKLVLGIIFLFLVISITAGCGIGKEAEVKKSFEKTLSMYPIKNLEDLYDKEGYRD
************************************************************
COL DQFDKNDKGTWIINSEMVIQPNNEDMVAKGMVLYMNRNTKTTNGYYYVDVTKDEDEGKPH
N315 DQFDKNDKGTWIINSEMVIQPNNEDMVAKGMVLYMNRNTKTTNGYYYVDVTKDEDEGKPH
NCTC8325 DQFDKNDKGTWIINSEMVIQPNNEDMVAKGMVLYMNRNTKTTNGYYYVDVTKDEDEGKPH
Newman DQFDKNDKGTWIINSEMVIQPNNEDMVAKGMVLYMNRNTKTTNGYYYVDVTKDEDEGKPH
USA300_FPR3757 DQFDKNDKGTWIINSEMVIQPNNEDMVAKGMVLYMNRNTKTTNGYYYVDVTKDEDEGKPH
************************************************************
COL DNEKRYPVKMVDNKIIPTKEIKDEKIKKEIENFKFFVQYGDFKNLKNYKDGDISYNPEVP
N315 DNEKRYPVKMVDNKIIPTKEIKDKNIKKEIENFKFFVQYGNFKDLSKYKDGDISYNPEVP
NCTC8325 DNEKRYPVKMVDNKIIPTKEIKDEKIKKEIENFKFFVQYGDFKNLKNYKDGDISYNPEVP
Newman DNEKRYPVKMVDNKIIPTKEIKDEKIKKEIENFKFFVQYGDFKNLKNYKDGDISYNPEVP
USA300_FPR3757 DNEKRYPVKMVDNKIIPTKEIKDEKIKKEIENFKFFVQYGDFKNLKNYKDGDISYNPEVP
***********************::***************:**:*.:*************
COL SYSAKYQLTNDDYNVKQLRKRYDIPTSKAPKLLLKGSGNLKGSSVGYKDIEFTFVEKKEE
N315 SYSAKYQVTNDDYNVKQLRKRYDIPTNKAPKLLLKGTGNLKGSSVGYKDIEFTFVEKKGE
NCTC8325 SYSAKYQLTNDDYNVKQLRKRYDIPTSKAPKLLLKGSGNLKGSSVGYKDIEFTFVEKKEE
Newman SYSAKYQLTNDDYNVKQLRKRYDIPTSKAPKLLLKGSGNLKGSSVGYKDIEFTFVEKKEE
USA300_FPR3757 SYSAKYQLTNDDYNVKQLRKRYDIPTSKAPKLLLKGSGNLKGSSVGYKDIEFTFVEKKEE
*******:******************.*********:********************* *
COL NIYFSDSLDYKKSGDV
N315 NIYFSDSLHLEPSEDK
NCTC8325 NIYFSDSLDYKKSGDV
Newman NIYFSDSLDYKKSGDV
USA300_FPR3757 NIYFSDSLDYKKSGDV
********. : * *
- ↑ Darya Belikova, Angelika Jochim, Jeffrey Power, Matthew T G Holden, Simon Heilbronner
"Gene accordions" cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus.
Nat Commun: 2020, 11(1);3526
[PubMed:32665571] [WorldCat.org] [DOI] (I e)Christina Schluepen, Enrico Malito, Ambra Marongiu, Markus Schirle, Elisabeth McWhinnie, Paola Lo Surdo, Marco Biancucci, Fabiana Falugi, Vincenzo Nardi-Dei, Sara Marchi, Maria Rita Fontana, Benedetta Lombardi, Maria Grazia De Falco, C Daniela Rinaudo, Glen Spraggon, Mikkel Nissum, Fabio Bagnoli, Guido Grandi, Matthew J Bottomley, Sabrina Liberatori
Mining the bacterial unknown proteome: identification and characterization of a novel family of highly conserved protective antigens in Staphylococcus aureus.
Biochem J: 2013, 455(3);273-84
[PubMed:23895222] [WorldCat.org] [DOI] (I p)Jeffrey S Kavanaugh, Caralyn E Flack, Jessica Lister, Erica B Ricker, Carolyn B Ibberson, Christian Jenul, Derek E Moormeier, Elizabeth A Delmain, Kenneth W Bayles, Alexander R Horswill
Identification of Extracellular DNA-Binding Proteins in the Biofilm Matrix.
mBio: 2019, 10(3);
[PubMed:31239382] [WorldCat.org] [DOI] (I e)