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Summary[edit | edit source]

  • pan ID?: SAUPAN001188000
  • symbol?: esxD
  • synonym:
  • description?: type VII secretion system extracellular protein EsxD
  • strand?: +
  • coordinates?: 1458536..1459691
  • synteny block?: BlockID0007040
  • occurrence?: in 68% of 34 strains

esxD : type VIIb/ESAT-6 secretion cargo stabilization complex component EsxD [1]

Staphylococcus aureus encodes a toxin secretion system called either the "Type VIIb Secretion" or "ESAT-6" pathway. EsxBCD surround the toxin "cargo" and the Esx-cargo complex is loaded onto a "translocon" system for transport across the staphylococcal membrane. A dedicated peptidoglycan amidase/endopeptidase (EssH) hydrolyzes the cell wall to allow translocated (exported) cargo access to the extracellular environment.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_0291
    08BA02176:
    11819-97:
    MS7_0282
    6850:
    RSAU_000237
    71193:
    ECT-R 2:
    ECTR2_252
    ED133:
    SAOV_0234
    ED98:
    SAAV_0259
    HO 5096 0412:
    JH1:
    SaurJH1_0282
    JH9:
    SaurJH9_0275
    JKD6008:
    JKD6159:
    SAA6159_00272
    JSNZ:
    JSNZ_000235 (esxD)
    LGA251:
    M013:
    MRSA252:
    MSHR1132:
    SAMSHR1132_02590
    MSSA476:
    SAS0267
    Mu3:
    SAHV_0289
    Mu50:
    SAV0292
    MW2:
    MW0267
    RF122:
    SAB0232
    ST398:
    T0131:
    TCH60:
    TW20:
    USA300_TCH1516:
    USA300HOU_0306
    VC40:
    SAVC_01210

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
    N315            MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
    NCTC8325        MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
    Newman          MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
    USA300_FPR3757  MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
                    ************************************************************

    COL             ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
    N315            ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
    NCTC8325        ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
    Newman          ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
    USA300_FPR3757  ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
                    *********************************************

  1. Yaping Yang, Eleanor Boardman, Justin Deme, Felicity Alcock, Susan Lea, Tracy Palmer
    Three small partner proteins facilitate the type VII-dependent secretion of an antibacterial nuclease.
    mBio: 2023, 14(5);e0210023
    [PubMed:37815362] [WorldCat.org] [DOI] (I p)