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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001188000
- symbol?: esxD
- synonym:
- description?: type VII secretion system extracellular protein EsxD
- strand?: +
- coordinates?: 1458536..1459691
- synteny block?: BlockID0007040
- occurrence?: in 68% of 34 strains
esxD : type VIIb/ESAT-6 secretion cargo stabilization complex component EsxD [1]
• Staphylococcus aureus encodes a toxin secretion system called either the "Type VIIb Secretion" or "ESAT-6" pathway. EsxBCD surround the toxin "cargo" and the Esx-cargo complex is loaded onto a "translocon" system for transport across the staphylococcal membrane. A dedicated peptidoglycan amidase/endopeptidase (EssH) hydrolyzes the cell wall to allow translocated (exported) cargo access to the extracellular environment.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0291
08BA02176:
—
11819-97:
MS7_0282
6850:
RSAU_000237
71193:
—
ECT-R 2:
ECTR2_252
ED133:
SAOV_0234
ED98:
SAAV_0259
HO 5096 0412:
—
JH1:
SaurJH1_0282
JH9:
SaurJH9_0275
JKD6008:
—
JKD6159:
SAA6159_00272
JSNZ:
JSNZ_000235 (esxD)
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
SAMSHR1132_02590
MSSA476:
SAS0267
Mu3:
SAHV_0289
Mu50:
SAV0292
MW2:
MW0267
RF122:
SAB0232
ST398:
—
T0131:
—
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_0306
VC40:
SAVC_01210
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
N315 MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
NCTC8325 MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
Newman MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
USA300_FPR3757 MTLSGKISVKAETIAHVVKELESISQKYDEIAQNFGKIAQLNYYSSEKAAHSMENGYSSA
************************************************************
COL ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
N315 ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
NCTC8325 ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
Newman ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
USA300_FPR3757 ATVISGLKGPLSTLGGGVMNSAQKFFEADEHWGTEFAKLYYNIEG
*********************************************
- ↑ Yaping Yang, Eleanor Boardman, Justin Deme, Felicity Alcock, Susan Lea, Tracy Palmer
Three small partner proteins facilitate the type VII-dependent secretion of an antibacterial nuclease.
mBio: 2023, 14(5);e0210023
[PubMed:37815362] [WorldCat.org] [DOI] (I p)